A5034378390- Cervical Cancer and HPV Research
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Oral and gingival health research
- HIV/AIDS oral health manifestations
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Vitamin D Research Studies
- Poxvirus research and outbreaks
- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Digestive system and related health
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial Peptides and Activities
- Women's cancer prevention and management
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- RNA regulation and disease
- Animal Disease Management and Epidemiology
- Botulinum Toxin and Related Neurological Disorders
Universidade Federal Rural de Pernambuco
2016-2023
Universidade Federal de Pernambuco
2013-2023
Hospital das Clínicas da Universidade Federal de Pernambuco
2023
Universidade de Pernambuco
2017-2020
Abstract The most commonly used Parkinson's disease (PD) treatment is the replacement of dopamine by its levodopa precursor ( l ‐dopa). Monoamine oxidase‐B (MAO‐B) and catechol‐o‐methyl transferase (COMT) are enzymes involved in metabolism regulation availability. In our study we investigated possible relation among selected single‐nucleotide polymorphisms (SNPs) MAO‐B (rs1799836) COMT (rs4680) genes therapeutic response to A total 162 Brazilian patients from Pro‐Parkinson service Clinics...
Bovine papillomavirus (BPV) is a diverse group of double-stranded DNA oncogenic viruses. BPVs are classically described as epitheliotropic, however, they have been detected in body fluids, such blood and semen. The presence BPV these sites can implications for the dissemination BPV. aim this study was to verify prevalence types cattle blood. A total 57 samples were analyzed by PCR using type-specific primers 1-6 8-10, subsequent sequencing. Sequencing quality determined Staden package with...
Abstract Objectives The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response levodopa (L-DOPA)-therapy in patients Parkinson's disease (PD). Methods One hundred ninety-five idiopathic PD were investigated. Patients genotyped for rs1800497 rs28363170 using PCR-RFLP. Logistic regression performed assess association occurrence chronic complications L-DOPA therapy. Key findings Our results...
Bovine papillomavirus (BPV) is a diverse group of double-stranded DNA oncogenic viruses, which have been detected in epithelial lesions and body fluids. Most studies BPV infection rely on single method for detection; however the use any or technique may underestimate true prevalence this virus. The purpose study was to compare two PCR strategies detection skin fluids: these involve type-specific consensus primers. Seventy-two cutaneous lesions, 57 blood samples 59 semen were collected. used...
Polymorphisms in chemokine receptors play an important role the progression of cervical intraepithelial neoplasia (CIN) to cancer (CC). Our study examined association CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility develop lesion (CIN and CC) a Brazilian population. The genotyping 139 women lesions 151 without for CCR5-Δ32 were performed using polymerase chain reaction-restriction fragment length polymorphism. individuals carrying heterozygous or homozygous...
Abstract Visual hallucinations are significant nonmotor symptoms in the course of treatment Parkinson's disease. Previous studies have shown that interindividual variability and pharmacogenetic profile disease patients seem to influence occurrence visual hallucinations. In our study, we investigated a possible relationship sequence variants DRD1 , DRD2 DRD3 DAT1 COMT genes with presence patients. A total 224 Brazilian from Pro‐Parkinson service at Clinical Hospital University Pernambuco,...
Abstract Aim The aim of the present study was to evaluate distribution single‐nucleotide polymorphisms ( SNP ) (variants FOKI [rs2228570], CDX 2 [rs47908762], and GATA [rs4516035]) in vitamin D receptor individuals with type diabetes mellitus chronic periodontitis DM + CP ), alone, healthy individuals, investigate relationship susceptibility . Methods In total, 280 (116 , 95 69 individuals) were genotyped using real‐time polymerase chain reaction allele‐specific probes. Significant...
Infection by high-risk human papillomavirus (HR-HPV) and single nucleotide polymorphism (SNP) in genes involved cell cycle control, as p21 p27, are important factors the development of different types cancers. This study aims at investigating whether both Ser31Arg p27 V109G polymorphisms associated with susceptibility to cervical lesions women HR-HPV positive. We analyzed 132 HPV positive or CC 154 healthy control (HPV negative without lesions). were using polymerase chain...
Objetivo: Comparar a condição periodontal entre crianças e adolescentes com diabetes tipo 1 pacientes saudáveis.Métodos: Foi realizado um estudo caso-controlo.160 6 13 anos foram submetidos ao exame clínico periodontal, sendo 60 casos 100 controlos.O nível de inserção clínica (NIC), profundidade à sondagem (PS), o sangramento (SS) presença placa visível (IPV) registados.Valores atualizados da hemoglobina glicada (HbA1c) dos anotados comparados aos demais dados.Para as análises estatísticas...
A infecção por um ou mais tipos de Papilomavírus Humano alto risco oncogênico (HR-HPV) tem sido relacionada à alta predisposição desenvolver câncer colo do útero. O objetivo presente estudo foi determinar a frequência quatro HR-HPVs (16, 18, 31 e 33) em mulheres assintomáticas Agreste Sertão Pernambucano avaliar outros fatores associados com infecção. Foram coletadas amostras secreção vaginal atendidas no Programa Saúde da Família - PSF cidade Serra Talhada-PE, período Janeiro Dezembro 2014....
Chronic periodontitis (CP) is a disease caused by an impaired immune response to oral bacteria and often found in individuals with type 2 diabetes mellitus (DM2). Dendritic cells are involved CP genetic polymorphisms the DC-SIGN receptor may modulate susceptibility disease. The aim of study was investigate distribution single nucleotide polymorphism DM2 CP, non-DM2 healthy controls its association sample population. 280 (116 DM2+CP, 95 69 controls) were genotyped using real-time PCR...
Cytokines have an important role in the progression of cervical lesions and/or adenocarcinoma. We investigated whether polymorphisms at promoter regions IL-10 -1082 (A> G, rs1800896) and TNF-α -308 (G>A, rs1800629) genes were associated with susceptibility to dysplasia The study consisted 240 women infected HPV (72 adenocarcinoma 168 intraepithelial lesions), 169 healthy control women. There was a significant increase frequency IL10 -1082G allele both (OR = 1.39; P 0.0372) patients...