CpXRh(III)-catalyzed C–H functionalization reactions are a proven method for the efficient assembly of small molecules. However, rationalization effects cyclopentadienyl (CpX) ligand structure on reaction rate and selectivity has been viewed as black box, truly systematic study is lacking. Consequently, predicting outcomes these challenging because subtle variations in can cause notable changes behavior. A predictive tool is, nonetheless, considerable value to community it would greatly...

Reliable design of artificial metalloenzymes (ArMs) to access transformations not observed in nature remains a long-standing and important challenge. We report that monomeric streptavidin (mSav) Rh(III) ArM permits asymmetric synthesis α,β-unsaturated-δ-lactams via tandem C-H activation [4+2] annulation reaction. These products are readily derivatized enantioenriched piperidines, the most common N-heterocycle found FDA approved pharmaceuticals. Desired δ-lactams achieved yields as high 99%...

The diastereoselective coupling of <italic>O</italic>-substituted arylhydroxamates and cyclopropenes mediated by Rh(<sc>iii</sc>) catalysis was successfully developed.

The emergence of SARS-CoV-2 in December 2019 has become a global issue due to the continuous upsurge patients and lack drug efficacy for treatment. 3CLPro is one most intriguing biomolecular targets among scientists worldwide developing antiviral drugs its relevance viral replication transcription. Herein, we utilized computer-assisted screening investigate 326 natural products from Thai traditional plants using structure-based virtual against 3CLPro. Following screening, top 15 compounds...

Conventionally, composite materials are usually employed as a catalyst in piezo-photocatalytic dye wastewater treatment. Here, we report the synthesis of ZnO nanoparticles, single-component catalyst, by surfactant-assisted precipitation which size nanoparticles (20-100 nm) can be simply controlled use Tween80 surfactant. Although, exhibited appreciable photocatalytic activities for degradation methylene blue (MB) dye, upon addition mechanical force, efficiency was substantially improved....

We report a RhIII -catalyzed regio- and diastereoselective synthesis of δ-lactams from readily available acrylamide derivatives unactivated alkenes. The reaction provides rapid route to diverse set in good yield stereoselectivity, which serve as useful building blocks for substituted piperidines. regioselectivity the with terminal alkene is significantly improved by using Cpt ligand on catalyst. synthetic utility demonstrated preparation potential drug candidate containing trisubstituted...

Staphylococcus aureus is an important human pathogen, especially causing skin and soft tissue infections (SSTIs). Over the decades, caused by antibiotic-resistant strains have often become life-threatening. Consequently, exploration development of competent approaches to combat these serious circumstances are urgently required.The antibacterial activity melittin (Mel) on S. aureus, methicillin-resistant (MRSA) clinical isolates vancomycin-intermediate (VISA) was investigated minimum...

New lanthanide coordination polymers, (I) [LnIII(Habtc)(H2O)2]·2H2O (Ln = SmIII, EuIII, GdIII, TbIII, DyIII, HoIII, ErIII, and TmIII), (II) [LnIII(Habtc)(H2O)4]·3H2O (LnIII TmIII, YbIII), (III) [EuIII2(Habtc)2(H2O)6]·2.75H2O (H4abtc 3,3′,5,5′-azobenzenetetracarboxylic acid), were designed synthesized for use as catalysts. The framework structures, phase formation, purity characterized. catalytic performances of [EuIII(Habtc)(H2O)2]·2H2O (Ib) [EuIII(Habtc)(H2O)4]·3H2O (IIb) evaluated based on...

Lanna painting is a unique type of in many temples the Northern Thai region. Similar to most mural paintings, they usually decay over time partly due activity microbes. This study aimed investigate microorganisms from two masterpiece paintings that differ numbers visitors using both culture-dependent and -independent approaches. The isolated murals were also tested for biodeterioration activities including discoloration, acid production calcium precipitation. Most extracted able discolor...

Tuberculosis (TB) therapy requires long-course multidrug regimens leading to the emergence of drug-resistant TB and increased public health burden worldwide. As treatment strategy is more challenging, seeking a potent non-antibiotic agent has been raised. Propolis serve as natural source bioactive molecules. It evidenced eliminate various microbial pathogens including Mycobacterium tuberculosis (Mtb). In this study, we fabricated niosome-based drug delivery platform for ethanolic extract...

Herpes simplex type 2 (HSV-2) infection causes a significant life-long disease. Long-term side effects of antiviral drugs can lead to the emergence drug resistance. Thus, propolis, natural product derived from beehives, has been proposed prevent or treat HSV-2 infections. Unfortunately, therapeutic applications propolis are still limited due its poor solubility. To overcome this, nanoparticle-based delivery system was employed. An ethanolic extract (EEP) encapsulated in nanoparticles...

Secretory phospholipase B1 (PLB1) and biofilms act as microbial virulence factors play an important role in pulmonary cryptococcosis. This study aims to formulate the ethanolic extract of propolis-loaded niosomes (Nio-EEP) evaluate biological activities occurring during PLB1 production biofilm formation Cryptococcus neoformans. Some physicochemical characterizations include a mean diameter 270 nm spherical shape, zeta-potential -10.54 ± 1.37 mV, 88.13 0.01% entrapment efficiency. Nio-EEP can...

Chronic wound infections are attributed to delayed tissue repair, which remains a major clinical challenge in long-term health care. Particularly, with antibiotic resistance have more serious effects on health, often resulting unsuccessful treatments. Thus, antimicrobial peptide (AMP)-based therapy holds promise as potential therapeutic approach overcoming drug resistance. Conventional dressing is passive strategy for care that not capable of eradicating pathogens and promoting repair. In...

The new nanoporous framework [Gd4(di-nitro-BPDC)4(NO2)3(OH)(H2O)5]·(solvent) (I; di-nitro-BPDC2- = 2,2'-dinitrobiphenyl-4,4'-dicarboxylate) has been designed and synthesized through a simple one-pot reaction. In addition to its exceptional thermal water stabilities, I exhibited multifunctional properties. A sudden CO2 uptake maximum of 4.51 mmol g-1 (195 K 1 bar) with notable selectivity over O2 N2 (CO2/O2 39 at 195 0.10 bar, CO2/N2 46 an isosteric adsorption enthalpy 20.7(4) kJ mol-1 have...

2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC, 1) was isolated from seeds of Syzygium nervosum A.Cunn. ex DC. exhibiting intriguing biological activities. Herein, thirty three DMC derivatives including 4'-O-monosubstituted-DMC (2), 7-O-acylated-4-hydroxycoumarin (3), stilbene-coumarin (4), 2',4'-disubstituted-DMC (5), and flavanone (6), were synthesised through acylation, alkylations, sulfonylation. These semi-synthetic evaluated for in vitro cytotoxicity against six carcinoma cell...

Diverse microorganisms from the three domains of life (Archaea, Bacteria, and Eukaryota) cause deterioration in mural paintings worldwide; however, few studies have simultaneously targeted these domains. This study aims to survey microbiome its potential for biodeterioration on unpreserved Lan Na Sean Khan temple, Chiang Mai, Thailand. The overview archaeal, bacterial, fungal communities was reported by Illumina sequencing, whereas revealed culturable techniques a literature search. abundant...

At present, there is no colorimetric method for the quantitation of aroma compound 2-acetyl-1-pyrroline (2AP). A novel was developed determination 2AP content using chromium hexacarbonyl (Cr(CO)6) as a reagent. The reaction synthetic with reagent solution in presence light produced green product an absorption maximum (λmax) at 623 nm. GC-MS used to confirm color-change reaction, which showed loss after addition Cr(CO)6. This enables facile and cost-effective fragrant rice. comparative...