A5005183330- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Bioactive natural compounds
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Analytical Chemistry and Chromatography
- biodegradable polymer synthesis and properties
- Molecular spectroscopy and chirality
- Organometallic Complex Synthesis and Catalysis
- Cancer Mechanisms and Therapy
- Axial and Atropisomeric Chirality Synthesis
- Moringa oleifera research and applications
- Pharmacological Effects of Natural Compounds
- Fungal and yeast genetics research
- Flavonoids in Medical Research
- Cancer therapeutics and mechanisms
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Bioactivity Studies
- Cell death mechanisms and regulation
- Berberine and alkaloids research
- Liver Disease and Transplantation
- Curcumin's Biomedical Applications
Chiang Mai University
2021-2025
The emergence of SARS-CoV-2 in December 2019 has become a global issue due to the continuous upsurge patients and lack drug efficacy for treatment. 3CLPro is one most intriguing biomolecular targets among scientists worldwide developing antiviral drugs its relevance viral replication transcription. Herein, we utilized computer-assisted screening investigate 326 natural products from Thai traditional plants using structure-based virtual against 3CLPro. Following screening, top 15 compounds...
The emergence of the COVID-19 situation has become a global issue due to lack effective antiviral drugs for treatment. Flavonoids are class plant secondary metabolites that have activity against SARS-CoV-2 through inhibition main protease (3CLpro). In this study, 22 flavonoids obtained from natural sources and semisynthetic approaches were investigated their inhibitory 3CLpro, along with cytotoxicity on Vero cells. protein–ligand interactions examined using molecular dynamics simulation....
Liver fibrosis, characterized by excessive extracellular matrix deposition, is driven activated hepatic stellate cells (HSCs). Due to the limited availability of anti-fibrotic drugs, research on therapeutic agents continues. Here we have investigated
2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC), a natural product derived from Syzygium nervosum A. Cunn. ex DC., was investigated for its inhibitory activities against various cancer cell lines. In this work, we the effects of DMC and available anticervical drugs (5-fluorouracil, cisplatin, doxorubicin) on three human cervical lines (C-33A, HeLa, SiHa). displayed antiproliferative activity in C-33A, SiHa cells, with IC50 values 15.76 ± 1.49, 10.05 0.22, 18.31 3.10 µM, respectively....
We modified the chemical structure of 2',4'-dihydroxy-6'‑methoxy-3',5'-dimethylchalcone (DMC, 1), a phytochemical found in seed Syzygium nervosum A.Cunn. ex DC., by conjugation with amino acid L-alanine (compound 3a) or L-valine 3b) to enhance anticancer activity and water solubility. Compounds 3a 3b had antiproliferative human cervical cancer cell lines (C-33A, SiHa HeLa), half-maximal inhibitory concentrations (IC50) 7.56 ± 0.27 8.24 0.14 µM, respectively cells; these values were...
The chemical structures of the parental compounds flavonoids from Boesenbergia rotunda were modified by conjugation with cinnamic acid to form cinnamoyl-flavonoid hybrid derivatives enhanced anti-inflammatory and SARS-CoV-2 Mpro-inhibitory properties. Cinnamoyl-flavonoid 6 10 showed potential inhibit Mpro IC50 values 52.49 22.62 μM. Compounds lower cytotoxicity in human lung cell lines MRC-5 A549 at concentrations greater than 50 effects on viability studied a 3D co-culture model treated...
Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) drug-resistant leukemic cells (K562/ADR). The cytotoxicity PGG was evaluated using a CCK-8 assay, cell apoptosis assessed flow cytometry. Western blotting used analyze protein expression levels. P-glycoprotein (P-gp) activity by monitoring kinetics...
Although cisplatin is a first-line chemotherapy drug for head and neck squamous cell carcinoma (HNSCC), its therapeutic efficacy limited owing to serious side effects acquired resistance. This study determined whether combining pentagalloyl glucose (PGG) enhanced their anti-tumor activities on HNSCC lines. We investigated the anticancer effect of PGG combined with in 2D 3D multicellular spheroid culture. The results revealed that inhibited viability produced synergistic effects. potentiates...
The quinazolinone scaffold is found in natural products and biologically active compounds, including inflammatory inhibitors. Major proteins or enzymes involved the inflammation process are regulated by amount of gene expression. Quinazolinone derivatives were investigated developed against genes cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cell line. mRNA...
Abstract This work investigates the high catalytic activity of bi‐functional lithium N ‐heterocyclic carbene ( bis LiNHCs) complexes in bulk ring‐opening polymerization (ROP) ε ‐caprolactone ‐CL) monomer at room temperature. The study employs a ROP technique using tetramethylene‐tethered [ ‐( ′‐alkyl/arylimidazolium)] hexafluorophosphate [Bim][PF 6 ]), benzyl alcohol (BnOH), and n ‐butyl BuLi) molar ratios 1:2:4. results show that 1,4‐ LiNHC 3a ) has highest capability, producing molecular...
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC, 1) was isolated from seeds of Syzygium nervosum A.Cunn. ex DC. exhibiting intriguing biological activities. Herein, thirty three DMC derivatives including 4'-O-monosubstituted-DMC (2), 7-O-acylated-4-hydroxycoumarin (3), stilbene-coumarin (4), 2',4'-disubstituted-DMC (5), and flavanone (6), were synthesised through acylation, alkylations, sulfonylation. These semi-synthetic evaluated for in vitro cytotoxicity against six carcinoma cell...
A new imidazolium ionic liquid (IL) halide conjugated with dimethylcardamonin (DMC, 1 ), namely [Bbim]Br-DMC ( 3 was synthesised to improve the biological activity of natural chalcone. DMC isolated from seeds Syzygium nervosum A. Cunn. ex DC. which an effective anti-breast cancer agent. The compound and showed anticancer in MDA-MB-231 cells IC 50 values 14.54 ± 0.99 μM 7.40 0.15 μM, respectively. MTT assay that had cytotoxic effect at least two-fold greater than but low toxic normal Hs...
Talaromyces marneffei is a thermally dimorphic fungus that can cause life-threatening systemic mycoses, particularly in immunocompromised individuals. Fungal homeobox transcription factors control various developmental processes, including the regulation of sexual reproduction, morphology, metabolism, and virulence. However, function proteins T. has not been fully explored. Here, we searched genome for total predicted their biological relevance by performing gene expression analysis...
Methyl itaconate–anthracene adducts (MIAs) were applied for the absolute configuration determination of chiral secondary alcohols by 1 H NMR technique including DFT calculation and X-ray crystallography.
A study of the phytochemicals constituents stems of, Millettia phuwuaensis has led to isolation 7-methoxy-5/,6/- methylenedioxyisoflavone (1), and 12-deoxo-12α-hydroxyelliptone (2. Their structures were confirmed using NMR spectroscopy. Both extracts the purified compounds evaluated for their antibacterial, anti-HIV, cancer activity. The antibacterial test results pure compound were found be valuable, MIC is in range 12.5-200 mg/mL, of 0.188-6 respectively....