A5017737571- Quinazolinone synthesis and applications
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Carbon dioxide utilization in catalysis
- Axial and Atropisomeric Chirality Synthesis
- Surface Chemistry and Catalysis
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Immune Response and Inflammation
- Synthesis and Characterization of Heterocyclic Compounds
- Catalysts for Methane Reforming
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Ionic liquids properties and applications
- Advanced Synthetic Organic Chemistry
- Veterinary medicine and infectious diseases
- Microwave-Assisted Synthesis and Applications
Naresuan University
2021-2025
Pharmac
2023-2025
Chulabhorn Graduate Institute
2016-2023
Chulabhorn Research Institute
2023
Stockholm University
2019-2020
ABSTRACT Piper betle L. (Piperaceae) is a herbal plant used in Thai traditional medicine for its antifungal and antiallergic properties, particularly through topical application. This study aimed to optimize the extraction of leaves using natural deep eutectic solvents enhance efficiency eugenol, active compound leaves. Various types hydrogen bond donors—including glycolic acid, lactic malic tartaric ascorbic citric acid—were combined with acceptor, choline chloride, prepare solvents. The...
A facile green synthesis of the anti‐inflammatory gene expression 4H‐3,1‐benzoxazine was developed under a commercial copper catalytic system. Benzoxazines were synthesized from 2‐aminobenzyl alcohols and aromatic aldehydes including heterocyclic using an economical commercially available copper(I)iodide (CuI) as catalyst in presence base, tBuOK. Target products achieved moderate to high yields with up 75% isolated yield. 4H‐3,1‐Benzoxazine enabled down‐regulation inflammatory tumor necrosis...
Asymmetric hydrogenation of conjugated enones is one the most efficient and straightforward methods to prepare optically active ketones. In this study, chiral bidentate Ir–N,P complexes were utilized access these scaffolds for ketones bearing stereogenic center at both α- β-positions. Excellent enantiomeric excesses, up 99%, obtained, accompanied with good high isolated yields. Challenging dialkyl substituted substrates, which are difficult hydrogenate satisfactory induction, hydrogenated in...
Starting from bromo/iodobenzaldehyde derivatives, the corresponding (Z)- and (E)-(2-stilbenyl)methanols could be prepared in 2–5 steps via Pd-catalyzed cross-coupling reactions (Sonogashira Heck reactions) followed by aryllithium/aryl Grignard addition. For (E)-stilbenes, subsequent acid-mediated cyclization using p-TsOH immobilized on silica (PTS-Si) at low temperatures furnished 2,3-trans-1-indanols with complete stereocontrol C2–C3. Further oxidization of alcohol provided indanones, which...
Asymmetric hydrogenation is one of the most commonly used tools in organic synthesis, whereas, kinetic resolution via asymmetric was less developed.
Novel bidentate N-heterocyclic carbene-phosphine iridium complexes have been synthesized and evaluated in the hydrogenation of ketones. Reported catalytic systems require base additives and, if excluded, need elevated temperature or high pressure hydrogen gas to achieve satisfactory reactivity. The developed catalysts showed extremely reactivity good enantioselectivity under base-free mild conditions. In presence 1 mol % catalyst bar at room temperature, was complete 30 minutes giving up 96...
The quinazolinone scaffold is found in natural products and biologically active compounds, including inflammatory inhibitors. Major proteins or enzymes involved the inflammation process are regulated by amount of gene expression. Quinazolinone derivatives were investigated developed against genes cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cell line. mRNA...
Abstract Starting from (E)-(2-stilbenyl/styrenyl)methanols, two distinct scaffolds, namely isochroman-4-ols and 1,3-dihydroisobenzofurans (phthalans), could be synthesized via an epoxidation/cyclization strategy. Indenes, readily accessible the same starting materials, undergo epoxidation/ring-opening/cyclization to provide tetrahydro-2H-indeno[2,1-b]furan-2-ones. Stilbene/styrene/indene epoxidation by m-CPBA or DMDO converted nucleophilic olefin into electrophilic epoxide, which...
A facile and green one-pot synthesis of AChE quinazolinone inhibitors was developed using microwave irradiation under solvent free conditions. Quinazolinones were synthesized from 2-aminobenzamide derivatives various alcohols such as benzyl alcohol butanol economical commercially available copper a catalyst in the presence base, Cs2CO3. The desired products achieved moderate to high yields with up 92% isolated yield. These then evaluated for acetylcholinesterase inhibition so that they can...
Starting from benzaldehyde derivatives, the corresponding dibenzocycloheptenol could be prepared in five steps. Under both substrate (secondary vs tertiary alcohol and substituents on aromatic ring(s)) condition control, subsequent epoxidation acid-catalyzed epoxide opening/semipinacol rearrangement/aromatization afforded 9-anthraldehydes good yields, up to 88% over two The presence of electron-withdrawing group(s) ring(s) suppressed rate while semipinacol rearrangement step required...
Abstract A facile and green one‐pot synthesis of 2,3‐dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2‐aminobenzamide derivatives various aldehydes in aqueous solution under base catalyst free reaction conditions. The desired products, aliphatic aromatic substrates, obtained 5 minutes with up to 99 % isolated yields.