A5071481645- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Transcranial Magnetic Stimulation Studies
- RNA regulation and disease
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Heart Rate Variability and Autonomic Control
- Gastrointestinal motility and disorders
- Neutropenia and Cancer Infections
- Technology and Human Factors in Education and Health
- Dementia and Cognitive Impairment Research
- Phytochemistry and biological activities of Ficus species
- Dysphagia Assessment and Management
- Memory Processes and Influences
- Cardiovascular Syncope and Autonomic Disorders
- Medical Research and Treatments
- Extracellular vesicles in disease
- Face Recognition and Perception
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Antifungal resistance and susceptibility
China Rehabilitation Research Center
2020-2024
Capital Medical University
2020-2024
Jiangxi Normal University
2021
Parkinson's disease (PD) patients exhibit deficits in primary sensorimotor and higher-order executive functions. The gradient reflects the functional spectrum sensorimotor-associated areas of brain. We aimed to determine whether is disrupted PD how this disruption associated with treatment outcome. Seventy-six (mean age, 59.2 ± 12.4 years [standard deviation], 44 women) 34 controls participants 58.1 10.0 19 were evaluated. explored structural gradients control participants. Patients followed...
Abstract Background The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within beta frequency range. Additionally, enhanced gamma oscillations may serve as a compensatory mechanism for motor inhibition mediated by and also reinstate plasticity primary cortex affected disease. Transcranial alternating current stimulation (tACS) can synchronize endogenous exogenous rhythms, thereby modulating cortical activity. objective...
Abstract Background To improve understanding of gender differences on quality life (QoL) in patients with Parkinson's disease (PWP) a different race, the clinical features and health‐related (HRQoL) between male female PWP were studied small cohort early to middle stage Chinese PWP. Methods A cross‐sectional study was carried out. consecutively included from April 2020 July 2021 Beijing Rehabilitation Hospital. HRQoL, motor symptoms, nonmotor symptoms each patient evaluated. The demographic,...
Abstract Aims In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on rate cognitive decline for both global cognition and specific domains in a cohort patients from Parkinson's Progression Markers Initiative (PPMI). Method Prospectively longitudinal data were obtained PPMI cohort. NPS, including depression, anxiety, apathy, psychosis, impulse control disorders (ICDs), ability, evaluated by series questionnaires. Linear mixed‐effects models used relationship...
Parkinson's disease (PD) can be classified into three motor-based subtypes: postural instability/gait difficulty (PIGD), tremor dominant (TD), and indeterminate. The neuropathophysiological mechanisms of the motor subtypes are different, which may lead to different responses therapy. Sixty-nine patients with idiopathic (Hoehn–Yahr stage ≤ 3) were screened from 436 Parkinsonism recruited through outpatient services internet. According Movement Disorder Society Unified Disease Rating Scale...
Background: In normal subjects, the diaphragm plays a key functional role in postural stability, articulation, respiration, defecation, and urination. Objectives: The aim of this study was to investigate stability visceral function patients with Parkinson's disease (PD) compare by gender, Hoehn Yahr (H&Y) staging, motor subtypes. Methods: total, 79 were enrolled cross-sectional study. severity assessed Movement Disorder Society-Unified Disease Rating Scale III H&Y staging. Postural...
Rehabilitation has been proposed as a valid measure complementary to the management of Parkinson's disease (PD). However, mechanism underlying is not clear yet. The differential expressions exosomal messenger RNA (mRNA) and long noncoding RNAs (lncRNAs) may play critical role in PD progression rehabilitation. To compare mRNAs lncRNAs, patients with (PWPs, Hoehn Yahr stages 1.5-2.5, n = 6) age- sex-matched healthy controls (HCs, were included this study. All PWPs received 2-week...
Abstract Background As one of the imaging markers cerebral small vessel disease, lacunes has received little attention. The objective this study was to investigate associations lacunes, cognition and motor function in patients with Parkinson's disease (PD) whether these are independent other markers. Methods Patients were consecutively included from April 2019 July 2022 Beijing Rehabilitation Hospital. All underwent brain magnetic resonance scans, clinical scale evaluations,...
Constipation is a common nonmotor symptom of Parkinson disease (PD). can also impact patient's quality life. Chinese herbal medicines have been used for the treatment constipation in PD. This trial will evaluate efficacy and safety formula Bushen Yisui Ziyin Jiangzhuo (BYZJ) PD.This randomized, double-blind, placebo-controlled, multicenter clinical involve 4 hospitals Beijing, China. The study aim to recruit 90 PD patients with between 30 80 years-of age score 1 - on Hoehn Yahr scale. Once...
Orthostatic hypotension (OH) is common in patients with Parkinson's disease (PD). Early recognition OH required sensitive assessments. The purpose of this study was to determine whether blood pressure (BP) changes during exercise can predict the occurrence PD.This prospective cohort included 80 consecutive PD. All agreed participate a baseline evaluation and cardiopulmonary test (CPET). According initial active standing (AST), those without (PD-nonOH) at had their AST results followed up for...
Abstract Background Rehabilitation has been reported to improve the quality of life (QoL) patients with Parkinson's disease (PD). Nevertheless, not all are satisfied rehabilitation outcomes and could achieve a significant improvement in QoL. Objective To detect possible predictors QoL PD after rehabilitation. Methods A total 86 were included followed up for 3 months 39‐item Disease Questionnaire summary index (PDQ‐39 SI) as primary endpoint. All received 2 weeks multidisciplinary intensive...
ABSTRACT Background Tremor‐dominant (TD) and nontremor‐dominant (NTD) Parkinson's disease (PD) showed different responses to rehabilitation. However, the neural mechanism behind this remains unclear. Methods This cohort study explores changes in motor function, brain activation, functional connectivity following 2 weeks of rehabilitation TD‐PD NTD‐PD patients, respectively. A total 11 24 21 age‐matched healthy controls (HCs) were included. At baseline, all participants underwent magnetic...
Abstract Background First-line rehabilitative strategies to improve motor deficits are based on functional training (physical or occupational therapy), which has been demonstrated facilitate neural reorganisation. Accumulating evidence suggests that non-invasive brain stimulation techniques, such as repetitive TMS (rTMS), may enhance neuroplasticity, thereby facilitating reorganisation and recovery from Parkinson’s disease. Evidence also shows intermittent theta-burst (iTBS) can function...
Objective To observe curative and side effects of fluconazole in preventing treating fungal infection patients with acute leukemia.Methods 112 cases leukemia were divided into two groups.Group A was prevented group (25 cases).These had by oral administration 100 mg/d for 7 days when the peripheral white blood cell less than 2.0×109/L.Group B treated (87 intravenous drip 200 if they reach diagnosis standard.To characters leukemia,the occurrence ratio these groups fluconazole.Results The Group...
Abstract In clinical practice, the underlying pathogenesis of Parkinson’s disease (PD) remains unknown. Circular RNAs (circRNAs) have good biological properties and can be used as marker. Rehabilitation a third treatment alongside drug surgical has been shown to clinically effective, but biomarkers rehabilitation efficiency at genetic level is still lacking. this study we identified differentially expressed circRNAs in peripheral blood exosomes between PD patients health controls (HCs)...