A5043223624- Renal Diseases and Glomerulopathies
- Muscle and Compartmental Disorders
- Chronic Lymphocytic Leukemia Research
- Vagus Nerve Stimulation Research
- Sinusitis and nasal conditions
- Histone Deacetylase Inhibitors Research
- Hemoglobinopathies and Related Disorders
- stochastic dynamics and bifurcation
- Intensive Care Unit Cognitive Disorders
- Ubiquitin and proteasome pathways
- Nicotinic Acetylcholine Receptors Study
- Metabolism, Diabetes, and Cancer
- Lymphoma Diagnosis and Treatment
- Electroconvulsive Therapy Studies
- Erythropoietin and Anemia Treatment
- Renal and related cancers
- Dialysis and Renal Disease Management
- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
- Adrenal Hormones and Disorders
- Iron Metabolism and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Response and Inflammation
- Systemic Sclerosis and Related Diseases
Fujieda Municipal General Hospital
2024
Creative Commons
2023
Yale University
2022-2023
Hamamatsu University School of Medicine
2000-2022
Shizuoka University of Welfare
2015-2017
Kyoto University
2013
The progression of proteinuric kidney diseases is associated with podocyte loss but the mechanisms underlying this process remain unclear. Podocytes re-enter cell cycle to repair double-stranded DNA (dsDNA) breaks. However, unsuccessful can result in podocytes crossing G1/S checkpoint and undergoing abortive cytokinesis. In study, we identified Pfn1 as indispensable maintaining glomerular integrity - its tissue-specific mouse results severe proteinuria failure. Our suggest that phenotype due...
Background Intact expression of podocyte histone deacetylases (HDAC) during development is essential for maintaining a normal glomerular filtration barrier because its role in modulating DNA damage and preventing premature senescence. Methods Germline podocyte-specific Hdac1 2 ( / ) double-knockout mice were generated to examine the importance these enzymes development. Results Podocyte-specific loss resulted severe proteinuria, kidney failure, collapsing glomerulopathy. -deprived podocytes...
Toll-like receptor 9 (TLR9), which is activated by endogenously released mtDNA during sepsis, contributes to the development of polymicrobial septic acute kidney injury (AKI). However, downstream factors TLR9 AKI remain unknown. We hypothesized that IL-17A may play a critical role in development. To determine effects on production AKI, we used cecal ligation and puncture (CLP) model Tlr9 knockout ( Tlr9KO) mice wild-type (WT) littermates. also investigated pathway from activation dendritic...
Acute kidney injury (AKI) causes glucose and protein metabolism abnormalities that result in muscle wasting, thereby affecting the long-term prognosis of critical illness survivors. Here, we examined whether early intervention with treadmill exercise branched-chain amino acids (BCAA) can prevent AKI-related wasting reduced physical performance mice. Unilateral 15 min ischemia-reperfusion was induced contralateral nephrectomized mice, histological physiological changes were assessed compared...
Acute kidney injury (AKI) contributes to the development of acute lung (ALI) via proinflammatory responses. We hypothesized that activation a nicotinic acetylcholine receptor (nAChR), which exerts cholinergic anti-inflammatory effects on macrophages, could reduce ALI after AKI. aimed determine whether nAChR agonists AKI and macrophages in or spleen contribute improvement by agonists. induced male mice unilateral ischemia-reperfusion (IRI) with contralateral nephrectomy administered three...
We apply a simple Brownian ratchet model to an artificial molecular rotary system mounted in biological membrane, which the rotor always maintains unidirectional rotation response linearly polarized weak ac field. Because and stator compose system, we describe motion of tip with Langevin equation for particle two-dimensional three-tooth potential threefold symmetry. Unidirectional can be induced under field optimized by stochastic resonance, wherein mean angular momentum (MAM) exhibits...
We herein report the case of a hemodialysis patient whose response to an erythropoiesis-stimulating agent (ESA) improved following resection thyroid cancer. Her hemoglobin level remained below 7 g/dL, despite use ESA. During search for causes her hyporesponsiveness ESA, papillary cancer and aceruloplasminemia were found. The existence other potential causes, such as iron deficiency, infectious disease, severe hyperparathyroidism malnutrition ruled out. Following tumor, increased 10.2 g/dL...
Patients without detectable serum antiglomerular basement membrane (GBM) antibodies but with GBM staining for immunoglobulins (Ig), absence of a crescentic phenotype, mild renal insufficiency, and pulmonary hemorrhage have atypical anti-GBM diseases. We report the case 64-year-old man slowly progressive glomerulonephritis.A Peruvian presented persistent microscopic hematuria, proteinuria 2.1 g/g creatinine (Cr), Cr 1.00 mg/dL, C-reactive protein 0.80 mg/dL. Renal biopsy revealed necrotizing...
Pell, John F.; Reghuvaran, Anand; Nagata, Soichiro; Banu, Khadija; Shi, Hongmei; Chernova, Irene; Ishibe, Shuta; Menon, Madhav C. Author Information
Goto, Daiki; Nagata, Soichiro; Naito, Yoshitaka; Iwakura, Takamasa; Isobe, Shinsuke; Fujikura, Tomoyuki; Ohashi, Naro; Kato, Akihiko; Yasuda, Hideo; First Department of Medicine Author Information