A5010525910- Neonatal Respiratory Health Research
- Neonatal Health and Biochemistry
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Dental Anxiety and Anesthesia Techniques
- Erythrocyte Function and Pathophysiology
- Dental Erosion and Treatment
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Mechanical Circulatory Support Devices
- Neonatal and fetal brain pathology
- Blood groups and transfusion
- Neonatal skin health care
- Blood donation and transfusion practices
- Mesenchymal stem cell research
- Healthcare Facilities Design and Sustainability
- Blood Coagulation and Thrombosis Mechanisms
- Temporomandibular Joint Disorders
- Congenital Diaphragmatic Hernia Studies
- Central Venous Catheters and Hemodialysis
- Cardiovascular Issues in Pregnancy
- Intergenerational Family Dynamics and Caregiving
- Neuroscience of respiration and sleep
Leiden University Medical Center
2024-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018-2024
University of Milan
2011-2024
University of Bologna
2010
Caregiving experiences in dementia may have adverse effects on the caregiver's own physical and mental health. The Zarit Burden Interview (ZBI) is most widely used instrument for assessing family carer burden purpose of present study was to evaluate psychometric properties Italian version ZBI (I-ZBI).I-ZBI administered a non-randomized sample 273 caregivers related consecutively attending outpatients with previously established primary diagnosis dementia, according DSM-IV criteria....
Red blood cell (RBC) transfusion is often considered a life-saving measure in preterm neonates. However, it has been associated with detrimental effects on short-term morbidities and, recently, brain development. The aim of the present study was to evaluate association between RBC and long-term neurodevelopmental outcome cohort infants.
Objective We determined thromboelastographic (TEG) profiles of healthy very low birthweight infants (VLBWIs) the day birth and at set intervals during their first month. Design Prospective observational study with blinded clinical laboratory follow-up. Setting Level III neonatal intensive care unit (June 2015 to June 2018). Patients Consecutive qualifying VLBWIs were enrolled followed up for 30 days. Interventions main outcomes measures Laboratory (citrated-native TEG, prothrombin time (PT),...
Fresh frozen plasma (FFP) is largely misused in the neonatal setting. The aim of study to evaluate impact a Thromboelastography (TEG)-based Quality Improvement (QI) project on perioperative FFP use and outcomes. Retrospective pre-post implementation level-III NICU including all neonates undergoing major non-cardiac surgery before (01-12/2017) after (01-12/2019) intervention. In 2018, intervention included following: (1) Training TEG, (2) Implementation (3) Algorithm for TEG-directed...
Objective To determine variations in cord blood gas (CBG) parameters after 3‐minute delayed clamping (DCC) vaginal deliveries (VDs) and caesarean (CDs) at term without fetal distress. Design Prospective observational study. Setting University hospital. Sample CBG from 97 VDs 124 CDs Methods Comparison of paired arterial–venous drawn birth the unclamped 3‐minutes DCC for CDs. Main outcome measures Base excess, bicarbonate, haematocrit haemoglobin both arterial venous blood, lactate, neonatal...
Necrotizing enterocolitis (NEC) is a devastating gut disease in preterm neonates. In NEC animal models, mesenchymal stromal cells (MSCs) administration has reduced the incidence and severity of NEC. We developed characterized novel mouse model to evaluate effect human bone marrow-derived MSCs (hBM-MSCs) tissue regeneration epithelial repair. was induced C57BL/6 pups at postnatal days (PND) 3–6 by (A) gavage feeding term infant formula, (B) hypoxia/hypothermia, (C) lipopolysaccharide....
Viscoelastic coagulation tests provide valuable information in neonatal intensive care units (NICUs), but the lack of reference intervals still limits their decision-making power according to gestational age. The aim present study is evaluate hemostasis a cohort full-term (FT) and late-preterm (LP) infants using viscoelastic monitor (VCM®) system, new portable device that uses untreated whole blood.An observational was performed identify non-coagulopathic FT LP admitted III° level NICU...
Objective: To compare the effect of Delayed Cord Clamping (DCC) to Immediate (ICC) on phototherapy treatment in a cohort cesarean-delivered newborns with AB0-alloimmunization. Study Design: In retrospective study neonates Gestational Age (GA) ≥ 35 weeks and diagnosed AB0-alloimmunization before implementation DCC (ICC group) were compared born after (DCC group). The primary outcome was need for phototherapy. Secondary outcomes included hospital stay, readmission rate, extra intravenous...
Background and Aim: Intestinal failure-associated liver disease (IFALD) affects one-fifth of neonates receiving parenteral nutrition (PN) for more than 2 weeks. We aimed to define the effect IFALD on hemostasis preterm infants. Methods: This is an ancillary analysis a prospective study at defining coagulation in included exposed PN (at least 14 days), full-enteral feeding. compared thrombin generation presence thrombomodulin, defined as endogenous potential-ETP, PT, aPTT between infants with...
May-Hegglin anomaly (MHA) is a rare autosomal dominant disorder in the spectrum of myosin heavy chain-related disorders (MYH9-RD), characterized by congenital macrothrombocytopenia and white blood cell inclusions. MHA carries potential risk hemorrhagic complications. Bleeding diathesis usually mild, but sporadic, life-threatening events have been reported. Data regarding clinical course outcomes neonatal MYH9-RD are limited, specific guidelines on platelet transfusion asymptomatic patients...
Very preterm infants are exposed to prenatal inflammatory processes and early postnatal hemodynamic respiratory complications, but limited data available about the endothelial effect of these conditions. The present pilot study investigates perinatal phenotype in very (VPIs) explores its predictive value on neonatal mortality complications. Angiopoietin 1 (Ang-1), Ang-2, E-selectin, vascular adhesion molecule (VCAM-1), tissue factor (TF), endothelin (ET-1) concentrations were tested first...
Abstract Background Thrombocytopenia, common in preterm newborns, may increase bleeding risk and is often treated with transfusions. Recent studies reveal that transfusing platelets at a high threshold worsens outcomes, possibly due to “developmental mismatch” between adult‐derived neonatal hemostatic system. Cord blood‐derived platelet concentrates (CBPCs) could be an alternative for newborns. Our study aims produce evaluate the quality parameters of CBPCs during storage. Study Design...
Newborns exhibit a pro-coagulant hemostatic profile despite platelet hyporeactivity and reduced coagulation factors. Assessing infant hemostasis, particularly in preterm infants, is challenging, with inconsistent findings regarding the relationship between count function patients patent ductus arteriosus (PDA).
Extracorporeal membrane oxygenation (ECMO) is a lifesaving support for respiratory and cardiovascular failure. However, ECMO induces systemic inflammatory response syndrome that can lead to various complications, including endothelial dysfunction in the cerebral circulation. We aimed investigate whether ECMO-associated also affected coronary Ten-day-old piglets were randomized undergo either 8 h of veno-arterial (n = 5) or no treatment (Control, n 5). Hearts harvested arteries dissected...
Neonatal pulmonary air leak commonly occurs as a complication of mechanical ventilation in infants with underlying hyaline membrane disease. They can be managed conservatively or the application chest drain, but some severe cases pose significant challenge finding an alternative therapeutic solution. Selective bronchial occlusion represents unconventional rescue therapy for treating bronchopleural fistula resistant to standard therapy. A 27-week gestation preterm infant ventilated...