A5018617193- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Clinical Nutrition and Gastroenterology
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Sodium Intake and Health
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Amphibian and Reptile Biology
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Apelin-related biomedical research
- Chronic Kidney Disease and Diabetes
University of Missouri
2015-2024
Harry S. Truman Memorial Veterans' Hospital
2015-2024
Sapienza University of Rome
2023
Policlinico Umberto I
2023
University of Missouri Hospital
2007-2021
Diabetes Australia
2011-2019
Roche Pharma AG (Germany)
2018
Boehringer Ingelheim (Germany)
2018
University of Applied Sciences Biberach
2018
Memorial Hospital
2017
Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation heart failure with preserved ejection fraction. The especially pronounced obese women predict future cardiovascular disease (CVD) events this population. Recent clinical data suggest sodium glucose transporter-2 (SGLT2) inhibition reduces CVD individuals, but the mechanisms of protection unknown. To determine whether targeting SGLT2 improves relaxation, we utilized empagliflozin (EMPA) female db/db...
Enhanced activation of the mineralocorticoid receptors (MRs) in cardiovascular tissues increases oxidative stress, maladaptive immune responses, and inflammation with associated functional vascular abnormalities. We previously demonstrated that consumption a Western diet (WD) for 16 weeks results aortic stiffening, these abnormalities were prevented by systemic MR blockade female mice. However, cell-specific role endothelial cell (ECMR) effects has not been explored.We hypothesized specific...
Arterial stiffness is emerging as an independent risk factor for the development of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which lower serum by inhibiting SGLT2-mediated reabsorption in renal proximal tubules, have shown promise reducing arterial and cardiovascular disease individuals with type diabetes mellitus. Since hyperglycemia contributes to stiffness, we hypothesized that SGLT2 inhibitor empagliflozin (EMPA) would improve endothelial function,...
Women are especially predisposed to development of arterial stiffening secondary obesity because consumption excessive calories. Enhanced activation vascular mineralocorticoid receptors impairs insulin signaling, induces oxidative stress, inflammation, and maladaptive immune responses. We tested whether a subpressor dose receptor antagonist, spironolactone (1 mg/kg per day) prevents aortic femoral artery in female C57BL/6J mice fed high-fat/high-sugar western diet (WD) for 4 months (ie, from...
The rising obesity rates parallel increased consumption of a Western diet, high in fat and fructose, which is associated with uric acid. Population-based data support that elevated serum acids are left ventricular hypertrophy diastolic dysfunction. However, the mechanism by excess acid promotes these maladaptive cardiac effects has not been explored. In assessing role diet-induced increases acid, we hypothesized reductions would prevent development cardiomyocyte hypertrophy, stiffness,...
Overnutrition and insulin resistance are especially prominent risk factors for the development of cardiac diastolic dysfunction in females. We recently reported that consumption a Western diet (WD) containing excess fat (46%), sucrose (17.5%), high fructose corn syrup (17.5%) 16 weeks resulted aortic stiffening young female mice these abnormalities were prevented by mineralocorticoid receptor blockade. Herein, we extend those studies testing whether WD-induced contributing to impairment,...
Radiation therapy ( XRT ) for treatment of localized prostate cancer PCA has outcomes similar to surgery and medical therapy. Toxicities the relative radioresistance limit effectiveness this method. Safe effective radiosensitizing agents are lacking enhance . In study, effect in combination with agent resveratrol RSV was investigated a radioresistant cell line, PC ‐3. Our results show addition / synergistically enhanced ‐induced apoptosis inhibition ‐3 proliferation. The antiproliferative...
Cardiovascular disease (CVD), including heart failure, constitutes the main source of morbidity and mortality in men women with diabetes. Although healthy young are protected against CVD, postmenopausal diabetic lose this CVD protection. Obesity, insulin resistance, diabetes promote failure females, diastolic dysfunction is earliest manifestation failure. To examine mechanisms promoting insulin-resistant investigation evaluated impact 8 weeks a high-fructose/high-fat Western diet (WD) on...
Patients with obesity and diabetes mellitus exhibit a high prevalence of cardiac diastolic dysfunction (DD), an independent predictor cardiovascular events for which no evidence-based treatment exists. In light renin-angiotensin-aldosterone system activation in the cardioprotective action mineralocorticoid receptor (MR) antagonists systolic heart failure, we examined hypothesis that MR blockade blood pressure-independent low-dose spironolactone (LSp) would treat obesity-associated DD Zucker...
Type 2 diabetes is associated with diabetic cognopathy. Anti-hyperglycemic sodium glucose transporter (SGLT2) inhibitors have shown promise in reducing cognitive impairment mice type mellitus. We recently described marked ultrastructural (US) remodeling of the neurovascular unit (NVU) db/db female mice. Herein, we tested whether SGLT-2 inhibitor, empagliflozin (EMPA), protects NVU from abnormal cortical gray and subcortical white matter. Ten-week-old wild-type were divided into lean controls...
Insulin resistance is associated with obesity and may be accompanied by left ventricular diastolic dysfunction myocardial remodeling. Decreased insulin metabolic signaling increased oxidative stress promote these maladaptive changes. In this context, the beta-blocker nebivolol has been reported to improve sensitivity, increase endothelial NO synthase activity, reduce NADPH oxidase-induced superoxide generation. We hypothesized that would attenuate remodeling blunting oxidant promoting in a...
Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability glucagon-like peptide-1 an emerging therapy control glycemia in type 2 diabetes patients. Accumulating evidence suggests has insulin-independent actions tissue. However, it not known whether DPP-4 improves obesity-related diastolic dysfunction. Eight-week-old Zucker obese (ZO)...
Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and the associated pathological changes to vasculature right ventricle (RV).Increases in reactive oxygen species (ROS), altered redox state, elevated oxidant have been demonstrated lungs RV several animal models PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, transgenic Ren2 rat which overexpresses mouse renin gene.Generation ROS these is derived mostly from activities...