Self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) subunits with p-cymene (p-PriC6H4Me) or hexamethylbenzene (C6Me6) ruthenium building blocks and 2,5-dihydroxy-1,4-benzoquinonato (dhbq) 2,5-dihchloro-3,6-dihydroxy-1,4-benzoquinonato (dchq) bridges affords the triangular prismatic organometallic cations [Ru6(p-PriC6H4Me)6(tpt)2(dhbq)3]6+ ([1]6+), [Ru6(p-PriC6H4Me)6(tpt)2(dchq)3]6+ ([2]6+), [Ru6(C6Me6)6(tpt)2(dhbq)3]6+ ([3]6+), [Ru6(C6Me6)6(tpt)2(dchq)3]6+ ([4]6+). These...

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR UV-visible spectroscopy electrospray ionisation mass...

The highly cytotoxic diruthenium complex [(p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3)](+) (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of thiols cysteine and glutathione give corresponding disulfides, which may explain its high in vitro anticancer activity.

The relative affinity of the cationic triangular metallaprism, [(pCH3C6H4Pri)6Ru6(tpt)2(dhbq)3]6+ ([1]6+), for various amino acids, ascorbic acid, and glutathione (GSH) has been studied at 37 °C in aqueous solutions pD 7, using NMR spectroscopy electrospray ionization mass spectrometry (ESI-MS). metallaprism [1]6+, which is constituted six (pCH3C6H4Pri)Ru corners bridged by three 1,4-benzoquinonato (dhbq) ligands connected two 2,4,6tri(pyridin4yl)1,3,5-triazine (tpt) panels, disassembled...

Neutral dinuclear dithiolato-bridged pentamethylcyclopentadienyl Rh(III) complexes of the type (C5Me5)2Rh2(μ-SR)2Cl2 (R = CH2Ph, 1; R CH2CH2Ph, 2) and cationic trithiolato-bridged Ir(III) [(C5Me5)2M2(μ-SR)3]+ (M Rh, 3; M 5; CH2C6H4-p-tBu, 7: Ir, 4; 6; 8) have been synthesized from chloro-bridged dimers (C5Me5)2M2(μ-Cl)2Cl2 by reaction with corresponding thiol derivative (RSH). Complexes 3–8 were isolated as chloride salts. All obtained in good yield fully characterized spectroscopic methods....

Abstract After the Swiss ban of hexahydrocannabinol (HHC) in March 2023, other semisynthetic dibenzopyran cannabinoids emerged on gray market. Hexahydrocannabiphorol (HHCP) was most prominent them due to its potent cannabimimetic effects, as anecdotal reports from recreational users suggest. In October a class wide introduced Switzerland prevent new similar substances entering drug Various vendors online shops claim that HHCP is made CBD, even though they possess different alkyl chain...

A robust, versatile and easy to optimize HMBC experiment for complex organic structure elucidation which has been experimentally tested on cholesteryl acetate, cyclosporine isopropylidene glycerol is described. The proposed experiment, IMPACT-HMBC (improved accelerated constant-time heteronuclear multiple-bond correlation), combines sensitivity, experimental setup can be recorded with short recovery times.

Abstract Cationic (arene)ruthenium‐based tetranuclear complexes of the general formula [Ru 4 ( η 6 ‐p ‐cymene) μ‐N ∩ N ) 2 μ‐OO∩OO ] 4+ were obtained from dinuclear (arene)ruthenium ‐ p Cl ‐cymene=1‐methyl‐4‐(1‐methylethyl)benzene, OO∩OO =5,8‐dihydroxy‐1,4‐naphthoquinonato(2−), 9,10‐dihydroxy‐1,4‐anthraquinonato(2−), or 6,11‐dihydroxynaphthacene‐5,12‐dionato(2−)) by reaction with pyrazine bipyridine linkers =pyrazine, 4,4′‐bipyridine, 4,4′‐[(1 E )‐ethene‐1,2‐diyl]bis[pyridine]) in presence...

Incorporation of [60]fullerene (C(60)) within self-organizing systems is conceptually challenging but allows us to obtain materials which combine the characteristics (anisotropy, organization) condensed mesophases with properties C(60) (photo- and electrochemical activity). Here, we report on synthesis, characterization, liquid-crystalline four optically active fullerodendrimers, are chiral at point conjunction between fullerene scaffold mesogenic moieties. Thus, novelty this study take...

Abstract Cationic tetranuclear arene ruthenium complexes of the general formula [Ru 4 ( p ‐cymene) N ∩ ) 2 (dhnq) ] 4+ comprising rectangular structures are obtained in methanol from reaction dinuclear precursor Cl (dhnq = 5,8‐dihydroxy‐1,4‐naphthoquinonato) with pyrazine or bipyridine linkers [ pyrazine, 1 ; 4,4′‐bipyridine, 1,2‐bis(4‐pyridyl)ethylene, 3 presence AgCF SO . All – , isolated good yield as triflate salts, have been characterised by NMR and IR spectroscopy. The interaction...

Room-temperature ionic liquids (RTILs) are promising new electrolytes for efficient carbon dioxide reduction. However, due to their high viscosity, the mass transport of CO2 in RTILs is typically slow, at least one order magnitude slower than aqueous systems. One possibility improve decrease viscosity through dilution with water. Herein, defined amounts water added 1-butyl-3methylimidazolium tetrafluoroborate ([BMIm][BF4 ]), which a hydrophilic RTIL. Electrochemical measurements on quiescent...

A new series of cationic dinuclear p-cymene ruthenium complexes bridged by three thiophenolato ligands containing various substituents mainly in meta and ortho positions, [(η6-p-MeC6H4Pri)2Ru2(μ2-SR)3]+ (R = 3-C6H4Me: 1; R 3-C6H4OMe: 2; 3-C6H4OEt: 3; 3-C6H4CF3: 4; 3-C6H4NH2: 5; 3-C6H4Cl: 6; 2-C6H4Me: 7; 2-C6H4OMe: 8; 2-C6H4Pri: 9; 2-C6H4CF3: 10; npt: 11 (npt 2-naphthyl); mco: 12 (mco 4-methylcoumarinyl); 3,5-C6H3Me2: 13; 3,5-C6H3(CF3)2: 14; 3,5-C6H3Cl2: 15; 3,4-C6H3(OMe)2: 16), have been...

ABSTRACT The in vitro effects of 18 dinuclear thiolato-bridged arene ruthenium complexes (1 monohiolato compound, 4 dithiolato compounds, and 13 trithiolato compounds), originally designed as anticancer agents, on the apicomplexan parasite Toxoplasma gondii grown human foreskin fibroblast (HFF) host cells were studied. Some compounds exhibited antiparasitic efficacy at concentrations 250 nM below. Among those, complex 1 2 inhibited T. proliferation with 50% inhibitory (IC 50 s) 34 62 nM,...

Abstract Hsp90 is one of the most abundant chaperone proteins in cytosol. In an ATP‐dependent manner it plays essential role folding and activation a range client involved signal transduction cell cycle regulation. We used NMR shift perturbation experiments to obtain information on structural implications binding AMP‐PNP (adenylyl‐imidodiphosphate—a non‐hydrolysable ATP analogue), ADP inhibitors radicicol geldanamycin. Analysis 1 H, 15 N correlation spectra showed specific pattern chemical...

While residual dipolar couplings (RDCs) are an established method in high-resolution biomolecular NMR, their use for structure determination of small molecules organic solvents is limited by the alignment media available. Only recently stretched polystyrene (PS) gels were introduced measurement RDCs on compounds that allowed urgently needed free scalability induced anisotropy. Here, properties such PS different as well magnetic field strengths and temperatures studied practical...

Plasmodium parasites are exposed to higher fluxes of reactive oxygen species and need high activities intracellular antioxidant systems providing a steady glutathione flux. As future generation dual drugs, 18 naphthoquinones phenols (or their reduced forms) containing three different linkers between the 4-aminoquinoline core redox active component were synthesized. Their antimalarial effects have been characterized in parasite assays using chloroquine-sensitive -resistant strains Plasmodium,...

The in vitro anticancer activity of the dinuclear trithiolato-bridged arene ruthenium complex diruthenium-1 (DiRu-1) was evaluated against a panel human cancer cell lines used as models for hepatocellular carcinoma (HepG2 cells), estrogen-responsive breast adenocarcinoma (MCF-7 and triple-negative (MDA-MB-231 cells). DiRu-1 is highly cytotoxic to these lines, demonstrating half-maximal inhibitory concentrations (IC50 ) low-nanomolar range (77±1.4 268.2±4.4 nm). main molecular mechanisms...

1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells treatment a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer (A2780), corresponding cisplatin resistant (A2780cisR), and human embryonic kidney (HEK-293) were each incubated for 24 h 72 compared untreated cells. Different responses obtained depending on cell type...