A5053545270- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Trace Elements in Health
- Cell Adhesion Molecules Research
- Skin Protection and Aging
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Collagen: Extraction and Characterization
- Wound Healing and Treatments
- Adipose Tissue and Metabolism
- Biomedical Ethics and Regulation
- Cellular Mechanics and Interactions
- Corneal Surgery and Treatments
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Prosthetics and Rehabilitation Robotics
- Biochemical and Molecular Research
- Research on Leishmaniasis Studies
- Cancer-related molecular mechanisms research
- Additive Manufacturing and 3D Printing Technologies
- Nutrition and Health in Aging
- Erythropoietin and Anemia Treatment
- Fibroblast Growth Factor Research
Christ University
2023
University of Michigan
2015-2022
Michigan United
2022
Oregon Health & Science University
2013-2014
Center for Infectious Disease Research
2010
Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 upregulated increased iron-levels in liver. Both hepatocytes and non-parenchymal liver cells have detectable mRNA. Here we showed that induction hepcidin dietary associated with elevation mRNA Consistently, incubation iron-saturated transferrin induces isolated hepatic stellate cells, but not These observations suggest important role...
Significance The canonical degradation pathway for plasma membrane proteins is through endocytosis and targeting to lysosomes. In some cases, undergo retrograde trafficking the endoplasmic reticulum (ER) extraction an reticulum-associated pathway. We identified a novel proteasome-mediated of iron transporter, ZIP14. Extraction ZIP14 occurred after endocytosis, but did not occur by ER. Both ubiquitination deglycosylation were prior degradation. To our knowledge, first multispanning protein...
Background The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that toxic or facing increasing resistance. New kill causative agents, subspecies of Trypanosoma brucei, therefore urgently needed. Little is known about cellular mechanisms lead death pathogenic bloodstream stage. Methodology/Principal Findings We conducted first side by comparison effects multiple inducers target different systems in form parasites, including six (pentamidine,...
Accurate in vitro modeling of healthy and disease conditions is crucial for assessing the safety efficacy novel therapeutics before clinical trials. For cardiac diseases, direct evaluation muscle contraction a reliable indicator overall tissue function, however, this often necessitates expensive low-throughput non-human vivo models. Moreover, animal models may not accurately predict human responses to compound exposure. Here, we have developed turnkey platform facile fabrication 3D...
Accurately modeling disease in vitro is vital for the development of new treatment strategies and therapeutics. For cardiac diseases, direct assessment contractile output “ultimate phenotype” a reliable metric to study overall tissue function, as other ‘proxy’ measurements or biomarkers are not good predictors muscle strength. Human 3D engineered heart tissues (EHTs) from induced pluripotent stem cells hold great potential function. However, bioengineering required generate these predictive...
Iron homeostasis is tightly controlled. Since there no regulated way of excreting excess iron, levels are finely tuned through dietary uptake. This mostly accomplished by the peptide hormone, hepcidin, which produced in liver and BMP‐signaling pathway. The hereditary hemochromatosis protein (HFE) transferrin receptor 2 (TfR2) form a complex regulate pathway response to blood transferrin‐bound iron levels. Mutations either result reduction BMP signaling hepcidin expression, leading overload....
Model systems that accurately recapitulate healthy and diseased function in a dish are critical for the development of novel therapeutics. For cardiac diseases, direct assessment contractile output constitutes most reliable metric with which to assess overall tissue function, as other ‘proxy’ measurements poor predictors muscle strength. 3D engineered tissues (EMTs) derived from iPSCs hold great potential modeling function. Here, we have developed platform device utilizes EMTs conjunction...