A5074507486- Gut microbiota and health
- Diet and metabolism studies
- Pediatric health and respiratory diseases
- Bariatric Surgery and Outcomes
- Dietary Effects on Health
- Infant Nutrition and Health
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
National Institute of Allergy and Infectious Diseases
2024-2025
National Institutes of Health
2024-2025
University of Maryland, Baltimore County
2023
Rutgers, The State University of New Jersey
2023
Bariatric surgery is highly effective in achieving weight loss children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, gut microbiome changes unknown. Here, we show that exhibit significant metabolome shifts several months after laparoscopic vertical sleeve gastrectomy (VSG), increased alpha diversity notably enrichment of oral-associated taxa. To assess causality microbiome/metabolome phenotype, pre-VSG post-VSG stool was transplanted...
Although the rapid development of therapeutic responses to combat SARS-CoV-2 represents a great human achievement, it also demonstrates untapped potential for advanced pandemic preparedness. Cross-species efficacy against multiple coronaviruses by main protease (MPro) inhibitor nirmatrelvir raises question its breadth inhibition and our preparedness future coronaviral threats. Herein, we describe sequence structural analyses 346 unique MPro enzymes from all represented in NCBI Virus...
ABSTRACT Background Bariatric surgery is highly effective in achieving weight loss children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, gut microbiome changes unknown. Objectives 1) To comprehensively examine metabolome after laparoscopic vertical sleeve gastrectomy (VSG) 2) to assess whether microbiome/metabolome observed VSG influence phenotype using germ-free murine models. Design A longitudinal observational study undergoing serial...