A5084468282- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
University of Manchester
2016-2018
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of proinflammatory cytokine interleukin-1β implicated in many inflammatory diseases. Here we show that several clinically approved widely used NSAIDs fenamate class are effective selective inhibitors via inhibition volume-regulated anion channel macrophages, independently COX Flufenamic acid mefenamic...
With current treatments for Alzheimer's disease (AD) only providing temporary symptomatic benefits, modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology AD. A new hypothesis has emerged, in which memory loss is considered a synapse failure caused by soluble amyloid-β oligomers (Aβo). These small Aβo, precede formation larger fibrillar assemblies, may be main cause AD pathologies. The aim study was to investigate effect acute...