A5042425193- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Scientific Computing and Data Management
- Peptidase Inhibition and Analysis
- Synthesis and pharmacology of benzodiazepine derivatives
- Advanced Synthetic Organic Chemistry
- Catalytic C–H Functionalization Methods
- Research on Leishmaniasis Studies
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Reactions
- Synthesis and Reactions of Organic Compounds
- Hormonal Regulation and Hypertension
- AI-based Problem Solving and Planning
- Trypanosoma species research and implications
- Neuropeptides and Animal Physiology
- Data Quality and Management
- Traditional and Medicinal Uses of Annonaceae
- Nicotinic Acetylcholine Receptors Study
- Phosphorus compounds and reactions
- Organic Chemistry Cycloaddition Reactions
- Neurological Disorders and Treatments
Excel Life Sciences (India)
2024
Institut de Chimie de Clermont-Ferrand
2013-2019
University of Cape Town
2017-2018
Université Clermont Auvergne
2013-2017
Sigma Clermont
2017
Centre National de la Recherche Scientifique
2013-2017
A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis hit-to-lead medicinal chemistry program. Structure-activity relationship investigations resulted in compounds with potent antiplasmodial activity against both chloroquine sensitive (NF54) and multidrug resistant (K1) strains of human malaria parasite Plasmodium falciparum. In humanized P. falciparum mouse efficacy model, one frontrunner showed vivo...
An abridged and far-reaching review communication on the construction of polysubstituted piperidinic core using diverse methodologies for benefit organic chemists interested in total synthesis biologically active compounds.
Scope and limitations in the diastereoselective preparation of 2,6-cis or 2,6-trans disubstituted piperidines are described, through intramolecular reaction chiral β'-carbamate-α,β-unsaturated ketone. This methodology has been applied to total synthesis a few well chosen examples, such as (-)-solenopsine A alkaloid (+)-241D.
A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as key step for generating the permits range substrates under mild conditions moderate high yield.
Abstract The cis/trans selectivity is influenced by the alcohol used for in situ acetalization.