About
Contact & Profiles
A5066167217
Research Areas
- Reproductive Biology and Fertility
- Cellular Mechanics and Interactions
- Animal Genetics and Reproduction
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
Howard Hughes Medical Institute
2017
Boston Children's Hospital
2017
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption CatSperz reduces current sperm rheotactic efficiency in mice, resulting severe male subfertility. Normally distributed linear quadrilateral nanodomains along flagellum, complex lacking CatSperζ is disrupted at ~0.8 μm intervals flagellum. This renders proximal flagellum inflexible alters 3D flagellar envelope, thus preventing from reorienting...
10.7554/elife.23082
article
EN
cc-by
eLife
2017-02-23
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