A5031784911- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Nonlinear Optical Materials Studies
- Laser-Ablation Synthesis of Nanoparticles
- Optical Imaging and Spectroscopy Techniques
- Mass Spectrometry Techniques and Applications
- 3D Printing in Biomedical Research
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
Instituto Nacional de Investigaciones Nucleares
2012-2023
Universidad Autónoma del Estado de México
2012-2017
177 Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim this research was synthesize Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold (AuNPs) in the dendritic cavity and evaluate radiopharmaceutical potential for targeted radiotherapy simultaneous detection folate receptors (FRs) gastrin-releasing peptide (GRPRs) overexpressed breast cancer cells. p-SCN-Benzyl-DOTA aqueous-basic medium dendrimer. carboxylate...
The integration of fluorescence and plasmonic properties into one molecule is importance in developing multifunctional imaging therapy nanoprobes. aim this research was to evaluate the fluorescent plasmonic-photothermal, therapeutic, radiotherapeutic potential 177Lu-dendrimer conjugated folate bombesin with gold nanoparticles dendritic cavity (177Lu-DenAuNP-folate-bombesin) when it internalized T47D breast cancer cells. intense near-Infrared (NIR) emitted at 825 nm from conjugate inside...
The aim of this study was to assess the effect laser heating a well-characterized gold nanoparticle (AuNP)-octreotide system on HeLa cell viability, evaluate its potential as suitable agent for plasmonic photothermal therapy.Octreotide is synthetic peptide derivative somatostatin with an survival cells. Peptides bound AuNPs are biocompatible and stable multimeric systems target-specific molecular recognition.Octreotide conjugated (∼20 nm) by spontaneous reaction thiol groups. nanoconjugate...
Cerenkov radiation (CR) is the emission of UV-vis light generated by de-excitation molecules in medium, after being polarized an excited particle traveling faster than speed light. When β particles travel through tissue with energies greater 219 keV, CR occurs. Tissues possess a spectral optical window 600 to 1100 nm. The within this range can be useful for quantitative preclinical studies using imaging and <italic>in-vivo</italic> evaluation Lu177-radiopharmaceuticals (β-particle emitters)....