A5084877491- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Radiotherapy Techniques
- Heavy metals in environment
- X-ray Spectroscopy and Fluorescence Analysis
- Photodynamic Therapy Research Studies
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- Analytical chemistry methods development
- Nuclear Physics and Applications
- Advanced biosensing and bioanalysis techniques
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Community Ecology and Physiology
- Radiation Dose and Imaging
- Air Quality and Health Impacts
- Medical Imaging and Pathology Studies
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- bioluminescence and chemiluminescence research
- Lichen and fungal ecology
- Gold and Silver Nanoparticles Synthesis and Applications
- Heavy Metals in Plants
Universidad Autónoma del Estado de México
2016-2025
Dalhousie University
2008-2018
Medicina
2018
Tribunal Electoral del Estado de México
2018
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015
Instituto Nacional de Investigaciones Nucleares
2015
Universidad Nacional Autónoma de México
2007-2008
Radiolabeled gold nanoparticles may function simultaneously as radiotherapy and thermal ablation systems. The gastrin‐releasing peptide receptor (GRP‐r) is overexpressed in prostate cancer, Lys 3 ‐bombesin a that binds with high affinity to the GRP‐r. HIV Tat(49–57) cell‐penetrating reaches DNA. In cancer cells, 177 Lu shows efficient crossfire effect, whereas 99m Tc internalized cell nuclei acts an effective system of targeted because biological Auger effect. aim this research was evaluate...
177 Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim this research was synthesize Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold (AuNPs) in the dendritic cavity and evaluate radiopharmaceutical potential for targeted radiotherapy simultaneous detection folate receptors (FRs) gastrin-releasing peptide (GRPRs) overexpressed breast cancer cells. p-SCN-Benzyl-DOTA aqueous-basic medium dendrimer. carboxylate...
The integration of fluorescence and plasmonic properties into one molecule is importance in developing multifunctional imaging therapy nanoprobes. aim this research was to evaluate the fluorescent plasmonic-photothermal, therapeutic, radiotherapeutic potential 177Lu-dendrimer conjugated folate bombesin with gold nanoparticles dendritic cavity (177Lu-DenAuNP-folate-bombesin) when it internalized T47D breast cancer cells. intense near-Infrared (NIR) emitted at 825 nm from conjugate inside...
The conjugation of peptides to gold nanoparticles (AuNPs) produces biocompatible and stable multimeric systems with target‐specific molecular recognition. Peptides based on the cyclic Arg‐Gly‐Asp (RGD) sequence have been reported as high‐affinity agents for α ( ν ) β (3) integrin. aim this research was prepare a system 177 Lu‐labeled conjugated c(RGDfK)C (cyclo(Arg‐Gly‐Asp‐Phe‐Lys)Cys) compare radiation‐absorbed dose that monomeric dimeric RGD integrin‐positive U87MG tumors in mice. DOTA‐GGC...
Backround Human tumors show intrinsic heterogeneity and changes in phenotype during disease progression, which implies different expression levels of cell surface receptors. The research on new heterodimeric lutetium-177 (177Lu)-radiopharmaceuticals interacting with two targets tumor cells is a strategy for improvement radiotheranostic performance. This study aimed to synthesize characterize the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin (177Lu-DOTA-iPSMA-Lys3-BN) heterodimer evaluate its...
The aim of this research was to evaluate the in vitro potential 177Lu-labeled gold nanoparticles conjugated cyclo-[RGDfK(C)] peptides (177Lu-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system MCF7 breast cancer cells. Peptides were AuNPs (20 nm) by spontaneous reaction with thiol group cysteine (C). After laser irradiation, presence c[RGDfK(C)]-AuNP cells caused significant increase temperature medium (50.5 °C, compared 40.3 °C without AuNPs) resulting...
<sup>99m</sup>Tc-HYNIC-DA incorporated into HDL nanoparticles can be used to image SR-B1 positive tumors.
Mie theory explains the interaction of light with a gold nanoparticle (AuNP) through absorption <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mrow><mml:mi>C</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">a</mml:mi><mml:mi mathvariant="normal">b</mml:mi><mml:mi mathvariant="normal">s</mml:mi></mml:mrow></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:math>, scattering id="M2"><mml:mo...