Jan‐Yow Chen

ORCID: 0000-0003-2139-8903
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About
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Research Areas
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Cardiac pacing and defibrillation studies
  • Cardiac electrophysiology and arrhythmias
  • Central Venous Catheters and Hemodialysis
  • Connexins and lens biology
  • Cardiac Fibrosis and Remodeling
  • Cardiomyopathy and Myosin Studies
  • Tea Polyphenols and Effects
  • Cardiac Valve Diseases and Treatments
  • Neurological disorders and treatments
  • Non-Invasive Vital Sign Monitoring
  • Folate and B Vitamins Research
  • Trace Elements in Health
  • Microbial Metabolism and Applications
  • Electrodeposition and Electroless Coatings
  • Muscle and Compartmental Disorders
  • Pharmacological Effects of Natural Compounds
  • Cystic Fibrosis Research Advances
  • HIV-related health complications and treatments
  • Asthma and respiratory diseases
  • Hearing, Cochlea, Tinnitus, Genetics
  • Venous Thromboembolism Diagnosis and Management
  • Optical Imaging and Spectroscopy Techniques
  • Aortic aneurysm repair treatments

China Medical University
2007-2024

China Medical University Hospital
2007-2024

National Yang Ming Chiao Tung University
2012-2022

National Chung Hsing University
2008-2020

China Medical University
2010-2018

Previous noninvasive measurements of the pulse waveform radial artery have not employed standard positioning procedures. Here, we propose a new measuring apparatus that has two-axis mechanism and employs procedure for detecting optimal site accurately pressure (PPW). A modified sensor was designed to simultaneously measure arterial diameter changed (ADCW) PPW. Considering as cylinder, measured would be distorted if were at middle width. Moreover, blood vessel is elastic, its compliance...

10.1109/tbme.2007.910681 article EN IEEE Transactions on Biomedical Engineering 2007-12-20

Acute ST-elevation myocardial infarction (STEMI) elicits a robust cardiomyocyte death and inflammatory responses despite timely revascularization.This phase 1, open-label, single-arm, first-in-human study aimed to assess the safety efficacy of combined intracoronary (IC) intravenous (IV) transplantation umbilical cord-derived mesenchymal stem cells (UMSC01) for heart repair in STEMI patients with impaired left ventricular ejection fraction (LVEF 30-49%) following successful reperfusion by...

10.3389/fcvm.2022.961920 article EN cc-by Frontiers in Cardiovascular Medicine 2022-08-09

Multiple intracardiac catheters are often necessary for electrophysiological study (EPS) and radiofrequency (RF) ablation therapy. Therefore, multiple venous sheath placement in one femoral vein is always required catheter insertion. The vascular complications incurred by of sheaths have not been fully studied. We utilized duplex ultrasonography to assess the veins before after procedure. This consisted 52 patients (68 veins) who underwent EPS RF Up three were inserted into a single vein....

10.1536/jhj.45.257 article EN Japanese Heart Journal 2004-01-01

Peripheral artery disease (PAD) is known to be an increased mortality risk in patients with end-stage renal (ESRD). The aim of this study was compare patient survival between subclinical PAD undergoing peritoneal dialysis (PD) and hemodialysis (HD). Subclinical peripheral defined as ankle-brachial index less than 0.9. This conducted from April 2005, the observation period ended on 30 June 2011. At end follow-up, status all assessed data were obtained for entire cohort. A total 91 (61 HD PD)...

10.7150/ijms.5091 article EN cc-by-nc International Journal of Medical Sciences 2013-01-01

The initiation of focal atrial tachycardia (AT) from the superior vena cava (SVC) remains unclear. In 3 patients (2 females, 1 male; aged 57, 66 and 50 years, respectively) with AT arising different parts SVC, occurred spontaneously, rather than being induced by electrical stimulation. cycle length was highly variable, ranging between 190 300 ms in patient 1, 180 320ms 2, 200 300ms 3. clinical or associated arrhythmias were fibrillation (AF) (patients 3) flutter (AFL) 3). A presumed SVC...

10.1253/jcj.65.1034 article EN Japanese Circulation Journal 2001-01-01

The health benefits of coixol, an active compound adlay seed, have attracted certain attention. Adlay seed is often adopted in traditional Chinese medicine for the treatment various inflammatory disorders. Thus, it hypothesized that coixol could protect neuronal cells.

10.2478/abm-2024-0030 article EN Asian Biomedicine 2024-10-01

Background It is well known that familial sick sinus syndrome (SSS) caused by functional alterations of ion channels and gap junction. Limited information available on the mechanism age-related non-familial SSS. Although evidence shows a close link between arrhythmia renin-angiotensin system (RAS), it remains to be determined whether RAS involved in pathogenesis Methods In this study, 113 patients with documented SSS 125 controls were screened for angiotensinogen (AGT) junction...

10.1371/journal.pone.0029951 article EN cc-by PLoS ONE 2012-01-05

Familial sick sinus syndrome is associated with gene mutations and dysfunction of ion channels. In contrast, degenerative fibrosis the node tissue plays an important role in pathogenesis acquired syndrome. There a close relationship between transforming growth factor-β1 mediated cardiac arrhythmia. It interest to examine whether involved syndrome.Overall, 110 patients SSS 137 age/gender-matched controls were screened for sodium channel polymorphisms using sequencing or restriction fragment...

10.1371/journal.pone.0158676 article EN cc-by PLoS ONE 2016-07-05

Abstract Impaired left atrial appendage ejection fraction (LAA-EF) and peak LAA flow velocity (LAA-FV) are associated with high thromboembolic risks in patients fibrillation (AF). Herein, we examined function among flutter (AFL) stratified by the CHA 2 DS -VASc score using transesophageal echocardiography (TEE). Of 231 consecutive typical AFL, 84 who fulfilled inclusion criteria were enrolled. Among them, 57 had ongoing AFL divided into isolated (n = 38) paroxysmal AF (PAF) 19) groups,...

10.1038/s41598-019-54505-3 article EN cc-by Scientific Reports 2019-11-28

Aim: Atrial fibrillation (AF) is characterized by the development of thromboembolic events and more prevalent among end-stage renal disease patients than in general population. Vascular access thrombosis (VAT) a major morbidity chronic hemodialysis (HD) patients; however, association between AF VAT unknown.Methods: We retrospectively reviewed HD with functional vascular 1997 2006. The was analyzed using Kaplan-Meier analysis multivariate Cox proportional hazards regression.Results: A total...

10.5551/jat.6296 article EN cc-by-nc-sa Journal of Atherosclerosis and Thrombosis 2011-01-01

Abstract Limited studies are available regarding the pathophysiological mechanism of acquired atrioventricular block (AVB). Matrix metalloproteinases (MMPs) and angiotensin-converting enzyme (ACE) have been implicated in pathogenesis arrhythmia. However, relationship between these molecules AVB is still unclear. One hundred two patients with documented 100 controls were studied. Gene polymorphisms MMP1 ACE encoding genes screened by gene sequencing method or polymerase chain...

10.1038/s41598-020-66896-9 article EN cc-by Scientific Reports 2020-06-18

QRS duration has been associated with the response to cardiac resynchronization therapy (CRT).However, methods for defining predict outcome of CRT have discrepancies in previous reports.The aim this study was determine an optimal measurement CRT.Sixty-one patients who received were analyzed.All had class III-IV heart failure, left ventricular ejection fraction not more than 35%, and complete bundle branch block.The shortest, longest, average durations from 12 leads each electrocardiogram...

10.1536/ihj.16-364 article EN International Heart Journal 2017-01-01

This report describes a patient who underwent implantation of an atriobiventricular pacemaker following AV junction ablation and insertion temporary right ventricular (RV) pacemaker. During implantation, intermittent loss sinus P wave tracking occurred when the three permanent leads were connected to generator. Analysis marker annotation disclosed abnormal sensing that reinitiated postventricular atrial blanking caused failure tracking. phenomenon disappeared after removing RV lead, but not...

10.1111/j.1540-8159.2004.00572.x article EN Pacing and Clinical Electrophysiology 2004-07-01

<i>Introduction:</i> Cellular mechanisms of adenosine include a direct effect on the activation adenosine-sensitive potassium current (I<sub>K,Ado</sub>) and an indirect antagonism catecholamine-stimulated adenylate cyclase activity. However, previous studies evaluating influence catecholamine activity electrophysiologic effects have yielded conflicting results. We tested hypotheses that if exerts its atrioventricular (AV) nodal blocking directly by activating...

10.1159/000063330 article EN Cardiology 2002-01-01
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