Objectives To assess the efficacy and safety of a novel cell therapy for male stress urinary incontinence consisting periurethral injection autologous adipose‐derived regenerative cells, to determine 1‐year outcomes. Methods A total 11 patients with persistent after prostate surgery were included in study. The Celution system was used isolate cells from abdominal adipose tissue obtained by liposuction. Subsequently, these mixture transurethrally injected into rhabdosphincter submucosal space...

Objectives: To report a novel cell therapy using autologous adipose tissue‐derived regenerative cells for male stress urinary incontinence caused by urethral sphincteric deficiency, and the outcomes in initial cases undergoing periurethral injection of cells. Methods: Three patients with moderate after radical prostatectomy holmium laser enucleation prostate were enrolled. Adipose isolated from abdominal tissue Celution system. Subsequently, cells, mixture transurethrally injected into...

To clarify the lower urinary tract function in mice, we compared bladder and urethral activity between rats mice with or without spinal cord injury (SCI). Female Sprague-Dawley C57BL/6N were divided into five groups:1) intact (SI) rats,2) SI mice,3) pudendal nerve transection (PNT) mice,4) (SCI) rats, 5) SCI mice. Continuous cystometry (CMG) external sphincter (EUS)-electromyogram (EMG) analyses conducted under an awake, restrained condition. During voiding contractions, animals exhibited...

Controlling the one-handed helicity in synthetic polymers is crucial for developing helical polymer-based advanced chiral materials. We now report that an extremely small amount of biphenylylacetylene (BPA) monomers (ca. 0.3–0.5 mol %) allows complete control throughout polymer chains mostly composed achiral BPAs. Chiral substituents introduced at 2-position biphenyl units BPA positioned vicinity backbones contribute to a significant amplification bias, as interpreted by theoretical modeling...

We examined bladder and urethral sphincter activity in mice with or without spinal cord injury (SCI) after C-fiber afferent desensitization induced by capsaicin pretreatment changes electrophysiological properties of mouse neurons 4 wk SCI. Female C57BL/6N were divided into four groups: 1) intact (SI)-control, 2) SI-capsaicin (Cap), 3) SCI-control, 4) SCI-Cap groups. Continuous cystometry external (EUS)-electromyogram (EMG) conducted under an awake condition. In the Cap groups, (25, 50, 100...

Abstract Objectives: To assess the validity of growth pattern as a unique prognostic parameter for clear cell renal carcinoma (ccRCC). Methods: In total, 561 patients with pathologic tumor stage 1 (pT1), pT2, and pT3a ccRCC without preoperative metastasis were evaluated. Clinicopathologic parameters, including stage, Fuhrman grade, necrosis, lymphovascular invasion, pattern, analyzed to predict disease-free survival (DFS) cancer-specific (CSS). Results: Growth patterns defined follows:...

Aims To investigate storage symptoms following robot‐assisted laparoscopic radical prostatectomy (RARP), focused on de novo overactive bladder (OAB), and to evaluate the factors related OAB occurrence. Methods We prospectively examined 245 patients without who underwent RARP for localized prostate cancer. Subjective objective in lower urinary tract were evaluated before after surgery. At 3 months RARP, divided into two groups: with (de group) those (OAB‐free group). compared operative...

Abstract Background Although the presence of intraductal carcinoma prostate (IDC‐P) influences biochemical failure in radical prostatectomy patients, no data are available regarding impact its integration into classification grade group system. Thus, aim this study was to enhance utility system by integrating IDC‐P. Methods This a retrospective evaluation 1019 patients with cancer who underwent between 2005 and 2013 without neoadjuvant or adjuvant therapy. The on age, prostate‐specific...

Objective To investigate the clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non‐neurogenic lower urinary tract symptoms. Methods A total of 638 treatment‐naive symptoms who underwent subjective objective evaluations were reviewed retrospectively. We divided patients into groups based on urodynamic findings, compared parameters obtained questionnaires non‐invasive tests. Detrusor was defined as contractility index...

This study aimed to evaluate lower urinary tract dysfunction after radical hysterectomy using urodynamic studies and identify biomarkers for detrusor underactivity via proteomic analysis. prospective single-center included women who underwent nerve-sparing cervical carcinoma. Preoperative postoperative assessments (at 1 6 months) the International Prostate Symptom Score (IPSS), Overactive Bladder Score, urethral pressure profiling, flow studies. Detrusor contractility was assessed projected...

Background High‐risk prostate cancer can be defined by a patient's Gleason score (GS), prostate‐specific antigen (PSA) level, and clinical T (cT) stage, but novel marker is needed due to heterogeneity of the disease. In this study, we evaluated whether intraductal carcinoma (IDC‐P) confirmed needle biopsy an adverse prognostic parameter for progression‐free survival (PFS) cancer‐specific (CSS) in patients with high‐risk cancer. Methods We retrospectively 204 treated radical prostatectomy...

BACKGROUND Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated effects on expression levels androgen-responsive genes and growth factors in rat prostate. METHODS was induced by Escherichia coli (strain 1677) injection (0.2 ml 1 × 108 CFU/ml) into urethra male Sprague–Dawley rats, ventral lobes prostate were harvested day 84. Rats given 10 mg/kg celecoxib during last month COX-2 inhibitor treated group. Histopathology multiplex...

Objective To investigate the effects of tadalafil on storage and voiding function in treatment‐naïve patients with lower urinary tract symptoms suggestive benign prostatic hyperplasia, based a urodynamic study. Methods This was an open‐labeled, single‐center, prospective A total 80 untreated outpatients hyperplasia received 5 mg/day for 12 weeks. Subjective objective findings obtained through studies, including cystometry pressure flow study, were evaluated before after treatment. Results 71...

Benign prostatic hyperplasia (BPH) is an age-related disease frequently associated with lower urinary tract symptoms (LUTS) that involves of both epithelial and stromal cells. Stromal fibrosis a distinctive feature BPH, but the exact mechanisms underlying this phenomenon are poorly understood.In current study, proteomics analyses were utilized to identify proteins altered in BPH compartment from patients symptomatic BPH. cells isolated histological nodules by laser capture microdissection...

Purpose: Some patients who undergo robot-assisted laparoscopic radical prostatectomy (RARP) continue to experience long-term urinary incontinence (UI). This study aimed evaluate easily obtainable factors that can predict UI following RARP. Materials and Methods: A total of 315 underwent RARP for localized prostatic cancer were analyzed. We separated the into two groups, namely, Continence group Incontinence group, according presence or absence at 12 months after surgery, we compared...

To investigate the long-term efficacy and safety of periurethral injection autologous adipose-derived regenerative cells for treatment post-prostatectomy stress urinary incontinence.A total 13 patients with persistent incontinence after prostate surgery (radical prostatectomy, 10 patients; holmium laser enucleation prostate, three patients) underwent were followed up >4 years. A 24-h pad test was carried out four consecutive days in each evaluation period, changes mean daily leakage volume...

Aims To compare the efficacy of fesoterodine or mirabegron add‐on therapy for persistent overactive bladder (OAB) symptoms despite silodosin monotherapy in men with lower urinary tract suggestive benign prostatic hyperplasia, both subjective and objective aspects. Methods A total 120 patients OAB were randomized to receive (4 mg/day) (50 12 weeks. At week 12, changes from baseline patients’ voiding/storage functions, as assessed using International Prostate Symptom Score (IPSS), symptom...

Objectives To analyze sequential changes of diabetic cystopathy based on urodynamic data in patients with diabetes mellitus. Methods Participants included male who underwent a pressure flow study at Nagoya University Graduate School Medicine, Nagoya, Japan, from April 2005 to October 2016. Patients previous history lower urinary tract dysfunction were excluded. Bladder was categorized into four patterns: (i) normal; (ii) detrusor overactivity normal contractility; (iii)...

Intraductal carcinoma of the prostate (IDC-P) has a poor prognosis and is thought to be completely resistant current therapies, including androgen deprivation therapy (ADT). However, date, there are no data showing direct evidence such resistance.We retrospectively evaluated 145 patients with high-risk cancer who underwent radical prostatectomy (RP) neoadjuvant ADT between 1991 2005. All patient were collected from slides prepared needle biopsy (NB) samples tissue RP specimens. Data analyzed...

Abstract Aims To investigate the usefulness of novel clinical diagnostic criteria based on noninvasive examination findings to diagnose urodynamic detrusor underactivity (DU) in men. Methods We developed predict presence DU men as follows: (a) bladder voiding efficiency <70% uroflowmetry, (b) existence “sawtooth and interrupted waveforms” (c) ultrasonography‐documented intravesical prostatic protrusion <10 mm. analyzed sensitivity, specificity, positive predictive value (PPV), negative...

Sassa N, Tsuzuki T, Fukatsu A, Majima Kimura Nishikimi Yoshino Y, Hattori R & Gotoh M (2012) Histopathology 61 , 620–628 Is pT3 urothelial carcinoma of the renal pelvis a homogeneous disease entity? Proposal for new subcategory classification Aims: The prognosis (UCRP) is heterogeneous, especially in patients. degree tumour parenchymal invasion not considered pathological (pT) staging. aim this study was to investigate whether quantitative assessment provides better estimation UCRP...

We investigated the efficacy of 2 α1-blockers with different affinities for α1-adrenoceptor subtypes silodosin and naftopidil in treatment benign prostatic enlargement complicated by overactive bladder.This was a prospective, open label, randomized, multicenter study 350 outpatients untreated associated urinary urgency at least once per week an OABSS (Overactive Bladder Symptom Score) 3 or greater. Patients were randomly assigned to receive 8 mg day 75 day. Changes parameters from baseline 4...

In order to clarify whether an alpha1A/D-adrenoceptor (α1 A/D-AR) antagonist, naftopidil, or a phosphodiesterase type 5 (PDE5) inhibitor, tadalafil, prevents bladder wall remodeling after spinal cord injury (SCI), we examined the and urethral activity as well ischemic fibrotic changes in using SCI rats with without naftopidil tadalafil treatment.Adult female Sprague-Dawley were divided into four groups: (1) normal (spinal intact); (2) vehicle SCI; (3) (4) groups. groups, underwent Th9-10...