A5082186179- Liver physiology and pathology
- Fibroblast Growth Factor Research
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Nerve injury and regeneration
- Wnt/β-catenin signaling in development and cancer
Austral University
2016-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2024
Abstract Background Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have pivotal role in liver fibrosis, being able to act both its promotion resolution. It well-known that mesenchymal stromal cells (MSCs) can modulate the immune/inflammatory cells. However, effects of MSCs over hMø context fibrosis remain unclear. We previously described evidence antifibrotic vivo applying MSCs, which were enhanced by forced overexpression insulin-like...
Liver fibrosis results from cycles of liver damage and scar formation. We herein aimed at analysing neural crest cells and/or bone marrow stromal contribution to the liver.Two one hepatectomy model were applied on double-transgenic loxP-Cre mouse lines.Increased numbers glia with more complex processes found in fibrotic livers. During embryonic development, only few traced marrow, a minor fraction mice different reporter strains analysed: therefore, origin such is doubtful. In liver,...