A5008791474- Thermodynamic properties of mixtures
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Chemical Thermodynamics and Molecular Structure
- Protein Degradation and Inhibitors
- Phase Equilibria and Thermodynamics
- Hematopoietic Stem Cell Transplantation
- Thyroid Cancer Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Ionic liquids properties and applications
- Inorganic and Organometallic Chemistry
- Supercapacitor Materials and Fabrication
- Nanoparticles: synthesis and applications
- Organic Electronics and Photovoltaics
- Quantum Dots Synthesis And Properties
- Chalcogenide Semiconductor Thin Films
- Viral Infections and Immunology Research
- Microbial Natural Products and Biosynthesis
- Chronic Lymphocytic Leukemia Research
- Innovative Teaching and Learning Methods
- Hepatocellular Carcinoma Treatment and Prognosis
Indira Gandhi National Open University
2012-2024
KIIT University
2024
Indian Institute of Technology Bhubaneswar
2024
XCell Science (United States)
2024
Exelixis (United States)
2021-2022
Indian Institute of Technology Delhi
2014-2021
Jazz Pharmaceuticals (United States)
2015-2019
The University of Texas MD Anderson Cancer Center
2018
University of Kansas Medical Center
2018
Oregon Health & Science University
2018
Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine and daunorubicin that delivers synergistic 5:1 drug ratio into leukemia cells to greater extent than normal bone marrow cells. Prior clinical studies demonstrated sustained exposure in vivo prolonged survival versus standard-of-care plus chemotherapy (7+3 regimen) older patients with newly diagnosed secondary acute myeloid (sAML). Patients Methods In this open-label, randomized, phase III trial, 309 age 60 75 years...
Cabozantinib has shown clinical activity in combination with checkpoint inhibitors solid tumours. The COSMIC-312 trial assessed cabozantinib plus atezolizumab versus sorafenib as first-line systemic treatment for advanced hepatocellular carcinoma.
Abstract Background At an interim analysis (median follow‐up, 6.2 months; n = 187), the phase 3 COSMIC‐311 trial met primary end point of progression‐free survival (PFS): cabozantinib improved PFS versus a placebo (median, not reached vs. 1.9 p < .0001) in patients with previously treated radioiodine‐refractory differentiated thyroid cancer (RAIR‐DTC). The results from exploratory using extended datacut are presented. Methods Patients 16 years old or older RAIR‐DTC who progressed on prior...
It is assumed that the valence v of bond between a metal M and non-metal X negligibly small but not equal to zero when distance them sum their R values; value derived here for d-block element with Pauling RX values does seem depend on oxidation state M.
Experimental values of density, viscosity, and refractive index at (298.15, 303.15, 308.15) K the speed sound data 298.15 for binary mixtures dimethyl carbonate with methanol, chloroform, carbon tetrachloride, cyclohexane, dichloromethane are presented over whole range mixture composition. From these data, excess molar volume, deviations in sound, isentropic compressibility, Lorenz−Lorentz refractivity have been calculated. These results fit to Redlich−Kister type polynomial equation third...
Experimental values of density, viscosity, and refractive index at 298.15, 303.15, 308.15 K, the speed sound 298.15 for binary mixtures 2-chloroethanol with n-alkanols (C1−C6) are presented over entire mole fraction range. Using these data, excess molar volume deviations in Δη, sound, Δu, isentropic compressibility, ΔkS, have been calculated. Excess quantities fitted to Redlich−Kister equation derive coefficients standard errors between experimental calculated quantities. Sign magnitude...
Experimental values of density, viscosity, and refractive index at (298.15, 303.15, 308.15) K the speed sound 298.15 for binary mixtures acrylonitrile with methyl acetate, ethyl propyl butyl 3-methylbutyl-2-acetate are presented over whole range mixture composition. From these data, excess molar volume, deviations in sound, isentropic compressibility, Lorenz−Lorentz refractivity have been calculated. These results fitted to Redlich−Kister type polynomial equation third degree derive...
Experimental densities, viscosities, and refractive indices at 298.15, 303.15, 308.15 K as well the speed of sound 298.15 are presented over entire mole fraction range for binary mixtures ethenylbenzene (styrene) with methanol, ethanol, butan-1-ol, pentan-1-ol, hexan-1-ol. The calculated excess molar volume data have been compared Flory Prigogine−Flory−Patterson (PFP) theories. deviations in logarithmic viscosity computed values Bloomfield Dewan equation. Refractive index used to calculate...
Recent expansion of immunocompromised population has led to significant rise in zygomycosis caused by filamentous fungus Rhizopus oryzae.Due emergence fungal resistance and side-effects antifungal drugs, there is increased demand for novel drug targets.The current study elucidates molecular interactions peptide drugs with G-6-P synthase (catalyzing the rate-limiting step cell wall biosynthetic pathway) R.oryzae docking studies.The PDB structures enzyme are not known which were predicted...
Magnetic nanoparticles are themselves a fascinating world due to their various applications in different fields mainly biomedical, catalysis, storage devices and many more. Till now magnetites have been explored extensively through routes whereas another oxide of iron that is maghemite needs attention yet be discovered aspects. Here we show the simple, facile less time consuming method synthesize superparamagnetic nanoparticles. The highlights novelty synthesis marked by use sodium...
Experimental results of density, viscosity, and refractive index at 298.15, 303.15, 308.15 K speed sound 298.15 in the binary mixtures methyl acetate + ethylene glycol or poly(ethylene glycol) are presented over whole range mixture composition. From these data, excess molar volume, VE, deviations Δη, refractivity, ΔR, sound, Δu, isentropic compressibility, ΔkS, have been calculated. These quantities fitted to Redlich−Kister type equation derive coefficients standard errors.
Abstract Viroporins are virally encoded, membrane-active proteins, which enhance viral replication and assist in egress of viruses from host cells. The 2B proteins the picornaviridae family known to have viroporin-like properties play critical roles during virus replication. protein Hepatitis A Virus (2B), an unusual picornavirus, is somewhat dissimilar its analogues several respects. HAV approximately 2.5 times length other does not disrupt calcium homeostasis or glycoprotein trafficking....
Experimental values of densities, viscosities, and refractive indices at 298.15, 303.15, 308.15 K while speed sound 298.15 for the binary mixtures 1-chloronaphthalene with benzene, methylbenzene, 1,4-dimethylbenzene, 1,3,5-trimethylbenzene, methoxybenzene are presented over entire mole fraction range. From these data, excess molar volume, deviations in viscosity, sound, isentropic compressibility, Lorenz−Lorentz refractivity have been calculated. These results fitted to Redlich−Kister type...
Daunorubicin can induce left ventricular dysfunction and QT interval prolongation. This study assessed the effects of CPX-351, a liposomal encapsulation cytarabine daunorubicin, on cardiac repolarization. Twenty-six adults with acute leukemia were treated CPX-351 for 1–2 induction cycles ≤ 4 consolidation cycles. The primary endpoint was mean change in QTcF from baseline. Mean changes < 10 ms at all time points. No clinically meaningful heart rate, QRS interval, PR or QTcB observed....
Abstract Thermodynamic interactions in binary mixtures of styrene with n-alkanes have been studied terms excess quantities using the experimental results density, viscosity, and speed sound at 298.15 K. Flory as well Prigogine–Flory–Patterson equations were used to calculate molar volume addition enthalpy, entropy, free-energy mixing functions. The viscosity analysed Bloomfield Dewan theory predict deviations, while speed-of-sound by Benson Kiyohara deviations isentropic compressibility....
The Angiogenin (ANG) gene is frequently mutated in patients suffering from the neurodegenerative disease - amyotrophic lateral sclerosis (ALS). Most of ALS-causing mutations affect either its ribonucleolytic or nuclear translocation activity. Here we report functional characterization two previously uncharacterized missense D22G and L35P. We predict nature loss-of-function(s) these mutants through our established Molecular Dynamics (MD) simulation extended to 100 ns, show that predictions...
Development of novel antivirals, which requires knowledge the viral life cycle in molecular detail, is a daunting task, involving extensive investments, and frequently resulting failure. As there exist significant commonalities among virus families manner host interaction, identifying targeting common rather than specific features may lead to development broadly useful antivirals. Here, we have targeted 3C protease Hepatitis A Virus (HAV), feco-orally transmitted family Picornaviridae, for...