A5072637879- Nicotinic Acetylcholine Receptors Study
- Streptococcal Infections and Treatments
- Receptor Mechanisms and Signaling
- Vagus Nerve Stimulation Research
- Burn Injury Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Rabies epidemiology and control
- Cardiac electrophysiology and arrhythmias
- Restraint-Related Deaths
- Adenosine and Purinergic Signaling
- Injury Epidemiology and Prevention
- Calpain Protease Function and Regulation
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Orthopedic Infections and Treatments
- Contact Dermatitis and Allergies
- Cardiovascular Syncope and Autonomic Disorders
- Infections and bacterial resistance
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Neuroscience of respiration and sleep
- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Antimicrobial Resistance in Staphylococcus
- Pressure Ulcer Prevention and Management
Centro Hospitalar de Lisboa Central
2020-2023
Universidade Federal de Minas Gerais
2009-2022
Hospital de São José
2018-2020
University of Lisbon
2015
Grupo Santa Casa de Belo Horizonte
2012
The renin-angiotensin (Ang) system plays a pivotal role in the pathogenesis of cardiovascular disease, with Ang II being major effector this system. Multiple lines evidence have shown that Ang-(1-7) exerts cardioprotective effects heart by counterregulating actions. questions remain are how and where its effects. By using combination molecular biology, confocal microscopy, transgenic rat model increased levels circulating (TGR[A1-7]3292), we evaluated signaling pathways involved...
Overwhelming evidence supports the importance of sympathetic nervous system in heart failure. In contrast, much less is known about role failing cholinergic neurotransmission cardiac disease. By using a unique genetically modified mouse line with reduced expression vesicular acetylcholine transporter (VAChT) and consequently decreased release acetylcholine, we investigated consequences altered tone for function. M-mode echocardiography, hemodynamic experiments, analysis isolated perfused...
Brain-derived neurotrophic factor (BDNF) promotes neuronal survival through TrkB-FL activation. The activation of adenosine A2A receptors (A2AR) is essential for most BDNF-mediated synaptic actions, such as plasticity, transmission and neurotransmitter release. We now aimed at evaluating the A2AR influence upon neuroprotection against Aβ25–35 toxicity in cultured neurons. Results showed that BDNF increases cell reduces caspase-3 calpain induced by amyloid-β (Aβ) peptide, a mechanism probably...
Autonomic dysfunction is observed in many cardiovascular diseases and contributes to cardiac remodeling heart disease. We previously reported that a decrease the expression levels of vesicular acetylcholine transporter (VAChT) genetically-modified homozygous mice (VAChT KDHOM) leads decreased cholinergic tone, autonomic imbalance phenotype resembling dysfunction. In order further understand molecular changes resulting from chronic long-term parasympathetic we undertook transcriptome-based,...
Necrotizing fasciitis is a severe soft tissue infection with high mortality rate and therefore requires emergent surgical treatment. Several microorganisms can cause this infection, Photobacterium damselae being one of them, only eight cases previously published in the literature. We report first ever case necrotizing fasciitis, caused by microorganism, Portugal. In patient survived after several debridement procedures reconstruction upper limb acellular dermal matrix skin graft. A brief...
It is well known that cholinergic hypofunction contributes to cardiac pathology, yet, the mechanisms involved remain unclear. Our previous study has shown genetically engineered model of deficit, vesicular acetylcholine transporter knockdown homozygous (VAChT KDHOM) mice, exhibit pathological remodeling and a gradual increase in mass with aging. Given an often caused by adrenergic hyperactivity, we hypothesized VAChT KDHOM mice might have norepinephrine (NE) levels. We thus investigated...
Fournier gangrene is a disease characterized by necrotizing fasciitis of the perineal and genital region, resulting from synergistic polymicrobiotic infection. Most infections can be localized to cutaneous, urethral, or rectal source culminate in fulminant sepsis. Current state art systemic broad-spectrum antibiotics serial aggressive debridement which result superficial defect wide dimensions. We compiled all cases that required reconstruction after Centro Hospitalar Universitário Lisboa...
Osteomyelitis of the hand is a rare entity and almost always occurs after catastrophic injuries. Streptococcus anginosus part normal microbial flora oral cavity gastrointestinal tract. It frequently associated with purulent infections in several anatomic locations but rarely harms bony structures. The occurrence osteomyelitis caused by this microorganism very unusual.We report clinical case 58-year-old Caucasian male, ex-smoker, medical history chronic hepatitis C virus infection, liver...
Stasis dermatitis is a pathologic condition of the skin that most commonly occurs in lower limb, where it caused by chronic venous insufficiency. upper limb rare.A 45-year-old male, resident Angola, presented to emergency department with an ulcer encompassing entire left forearm. Past medical history comprised arterial hypertension and end stage renal disease treated hemodialysis. Dialysis access consisted brachial-basilic AV graft obtained 4 years before. The patient also reported right...
It was recently developed a transgenic animal model with overexpression of cholinergic neurotransmission. This mouse, named ChAT-ChR2-EYFP, has several extra copies the vesicular acetylcholine transporter (VAChT) gene and exhibits three-fold increase in release acetylcholine. However, consequences VAChT protein to cardiovascular system have not yet been characterized. Therefore, we investigated effects on arterial pressure (AP) heart rate (HR) as well autonomic regulation. Mice were assigned...