A5114131091- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Genetics, Aging, and Longevity in Model Organisms
- HIV/AIDS Research and Interventions
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Ion channel regulation and function
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular and exercise physiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational exposure and asthma
- Environmental and biological studies
- HIV, Drug Use, Sexual Risk
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Exercise and Physiological Responses
- HIV-related health complications and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Soil Management and Crop Yield
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peripheral Neuropathies and Disorders
Universidade Católica de Brasília
2025
Escola Superior de Ciências da Saúde
2025
University Center of Brasília
2024
Universidade Federal de Minas Gerais
2008-2024
Agostinho Neto University
2024
Universidade Federal de Sergipe
2012
Almeida Memorial Hospital
2012
National Institute of Science and Technology
2012
Centro Universitário de Belo Horizonte
2009
Max Delbrück Center
2008
Recently there has been growing evidence suggesting that beneficial effects of angiotensin-(1-7) [Ang-(1-7)] in the heart are mediated by its receptor Mas. However, signaling pathways involved these cardiomyocytes unknown. Here, we investigated involvement Ang-(1-7)/Mas axis NO generation and Ca 2+ handling adult ventricular myocytes using a combination molecular biology, intracellular imaging, confocal microscopy. Acute Ang-(1-7) treatment (10 nmol/L) leads to production activates...
The renin-angiotensin (Ang) system plays a pivotal role in the pathogenesis of cardiovascular disease, with Ang II being major effector this system. Multiple lines evidence have shown that Ang-(1-7) exerts cardioprotective effects heart by counterregulating actions. questions remain are how and where its effects. By using combination molecular biology, confocal microscopy, transgenic rat model increased levels circulating (TGR[A1-7]3292), we evaluated signaling pathways involved...
Cholinergic control of the heart is exerted by two distinct branches; autonomic component represented parasympathetic nervous system, and recently described non-neuronal cardiomyocyte cholinergic machinery. Previous evidence has shown that reduced function leads to deleterious effects on myocardium. Yet, whether conditions increased signaling can offset pathological remodeling induced sympathetic hyperactivity, its consequences for these axes are unknown. Here, we investigated models...
The present study was designed to determine the effects of physical training on development cancer induced by injection Ehrlich tumor cells in mice. Male Swiss mice were subjected a swim protocol (5 days/wk for 6 wk, 1 h at 50% maximal capacity-trained groups) or remained sedentary their cages (sedentary groups). inoculation performed end fourth week, and animals killed after wk training. Heart solid weights recorded, volumes calculated. Portions tumors used evaluation macrophages neutrophil...
Objective: It has been shown that Ang-(1-7) cardioprotective actions. To directly investigate the effects of specifically in heart, we generated and characterized transgenic (TG) rats which express an Ang-(1-7)-producing fusion protein driven by α-MHC promoter. Methods Results: After microinjection transgene into fertilized rat zygotes, obtained four different lines. Homozygous animals were analyzed with regard to expression profile ribonuclease protection assay. Transgene was detected...
SUMMARY: Aims: Peripheral neuropathy (PN) is a common condition whose incidence approximately 8% in elderly persons. Neuropathic pain (NeP) has significant the general population and affects more than half of all patients with PN. The pathophysiology PN characterized by lesions myelin-producing Schwann cells peripheral nerves. Regeneration/protection myelin sheath after nerve lesion fundamental element repair Nucleotides such as uridine monophosphate (UMP) have proven to be efficacious...
O câncer de pele é o tipo mais comum neoplasia e representa um importante problema saúde pública mundial. Dividido em Melanoma Tumores Pele Não (TPNM), este último engloba subtipos como carcinoma basocelular (CBC) espinocelular (CEC). melanoma, embora agressivo, tem registrado avanços significativos no tratamento redução das taxas mortalidade devido à detecção precoce, imunoterapia terapias-alvo. Por outro lado, os TPNM, apesar apresentarem menor letalidade individual, são responsáveis por...
The Mas protooncogene encodes a G protein-coupled receptor that has been described as functional for the cardioprotective fragment of renin-angiotensin system (RAS), Angiotensin (Ang)-(1-7). aim this current study was to evaluate responsiveness expression in hearts during different physiological and pathological conditions rats. Physical training considered condition, while isoproterenol-induced hypertrophy, myocardial infarction DOCA-salt model hypertension were used models heart injury....
High serum levels of aldosterone have been linked to the development cardiac disease. In contrast, angiotensin (Ang)-(1-7) was extensively shown possess cardioprotective effects, including attenuation dysfunction induced by excessive mineralocorticoid activation in vivo, suggesting possible interactions between these 2 molecules. Here, we investigated whether there is cross-talk and Ang-(1-7) its functional consequences for calcium (Ca(2+)) signaling ventricular myocytes. Short-term effects...
Mineralocorticoids have been implicated in the pathogenesis of diastolic heart failure. On contrary, angiotensin (Ang)-(1–7) has emerged as a potential strategy for treatment cardiac dysfunction induced by excessive mineralocorticoid receptor activation. A critical question about cardioprotective effect Ang-(1–7) hypertensive models is its dependence on blood pressure (BP) reduction. Here, we addressed this investigating mechanisms involved cardioprotection against Sprague-Dawley (SD) and...
Human idiopathic pulmonary fibrosis (IPF) is a disease with unknown etiology and poor prognosis in which patients present decrease functional exercise tolerance quality of life. At present, no treatment can improve the this available. Many biomarkers have been studied, surfactant protein A (SP-A) expression considered specific marker lung disease. This study aimed to investigate influence training on endurance capacity murine-lung lesions induced by bleomycin (BLM). Thirty-four male Balb/c...
Protein restriction (PR) is associated with cardiovascular diseases. The purpose of this study was to investigate the effects on single ventricular cardiomyocyte contractile function a short-term PR after weaning. Male Fischer rats that were 28 days old randomly divided into control group (CG, n = 16) and protein-restricted (PRG, 16). After weaning, CG PRG animals received isocaloric diets containing 15 6% protein, respectively, for 35 days. Biometric parameters then measured, hearts removed...
There has been increasing evidence suggesting that a severe caloric restriction (SCR) (above 40%) beneficial effects on the hearts of rats. However, most reports have focused SCR started in adulthood. We investigated consequences rats subjected to since birth (CR50). From age 3 months, CR50 were fed 50% food ad libitum group (AL) was fed. Thereafter, maximal aerobic test performed indirectly evaluate global cardiovascular function. Indices contractility (+dT/dt) and relaxation (-dT/dt)...
In 1939, Hamman´s syndrome, also know as spontaneous pneumomediastinum, was characterized by the presence of pneumothorax, subcutaneous emphysema, and pneumorrhachis. It is believed to arise from barotrauma during vaginal labor, causing alveolar membrane rupture subsequent air leakage. Clinical manifestations are often nonspecific. Management strategies vary based on symptom severity complications, high-concentrations oxygen therapy promoting absorption. We present case an 18-year-old male...
We investigated the effects of palmitate, a high saturated fat, on Ca2+, action potential and reactive oxygen species dynamics in cardiomyocytes from untrained trained mice. Male mice were subjected to moderate intensity exercise training treadmill. Cardiomyocytes isolated, treated for 30 min with palmitate intracellular calcium transient duration recorded. Additionally, we assessed generation. Treatment induced significant decrease Ca2+ magnitude by 34%. Exercise did not change...
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A adesão à terapia antirretroviral (TARV) melhora a qualidade de vida das pessoas vivendo com HIV (PVHIV), ênfase na melhoria do status imunológico, redução da carga viral e diminuição taxa mortalidade pelo Vírus Imunodeficiência Humana (HIV). Este estudo teve como objetivo caracterizar o os fatores associados não entre pacientes adultos em duas unidades saúde referência para HIV/AIDS Luanda, capital Angola (Hospital Divina Providência Hospital Esperança/Centro Saúde Rangel). Trata-se um...
Increased thyroid hormone (TH) levels promote cardiac hypertrophy and arrhythmia by direct actions on myocardium interaction with other systems as local renin‐angiotensin system (RAS). Previous studies have confirmed that T3 rapidly increases AT1R angiotensin II protein in cultured cardiomyocytes. In the present study, we evaluated contribution of Ca 2+ transient cardiomyocytes treated T3. Adult ventricular (n=07) were isolated for 30 minutes (15nM, Sigma), plus losartan (LOS, 1µM, Sigma) or...
Mineralocorticoids have been implicated in the pathogenesis of cardiac diseases. In contraposition, Angiotensin (Ang)-(1-7) has shown to attenuate dysfunction induced by excessive mineralocorticoid receptor (MR) activation vivo , suggesting a possible interaction between these two signaling pathways heart. Here, we investigated whether there is cross-talk MR and Ang-(1-7) its consequences for cardiomyocyte function. For this, used transgenic rat that overexpress an Ang-(1-7)-producing fusion...
PURPOSE: One third of all deaths in the world 2020 are expected to be due cardiac diseases. Sedentary lifestyle and high fat diet related occurrence these Aerobic physical training has been prescribed as a way improve cardiovascular capacity. Cellular mechanisms concerning benefits aerobic (PT) cardiomyocytes poorly known. We investigated Ca2+ signaling properties mice maintained on high-fat (HF) PT. METHODS: Male C57BL/6J were fed with HF or control PT not trained (SED) for 5 weeks. was...