A5088550612- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Infant Health and Development
- Child Development and Digital Technology
- Child and Adolescent Psychosocial and Emotional Development
- Child and Animal Learning Development
- Neuroscience of respiration and sleep
Stanford University
2014-2019
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis poor, in part, because existing medications target only associated ASD features. Emerging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of functioning and possible treatment for ASD. However, prior OXT trials have produced equivocal results, perhaps variability patients' underlying biology, but this hypothesis has not been tested. Using double-blind, randomized,...
Intranasal delivery of the neuropeptide vasopressin improves social abilities in children with autism spectrum disorder.
Brain arginine vasopressin (AVP) critically regulates normative social behavior in mammals, and experimental disruption of the AVP signaling pathway produces impairments rodent models. We therefore hypothesized that deficits may contribute to children with autism spectrum disorder (ASD). Since blood measures (which are far easier obtain than brain measures) most meaningful if they related activity, Study 1 tested relationship between concentrations concomitantly collected CSF samples from...
Research suggests that children with autism spectrum disorder (ASD) may have reduced empathy, as measured by an impaired contagious yawn response, compared to typically developing (TD) children. Other research has failed replicate this finding, instead attributing phenomenon group differences in attention paid stimuli. A third possibility is only a subgroup of ASD exhibits the and it can be identified biologically. Here we quantified blood concentrations “social” neuropeptide oxytocin (OXT)...