A5022500245- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Global Public Health Policies and Epidemiology
- COVID-19 Digital Contact Tracing
- Psychology of Moral and Emotional Judgment
- Optimism, Hope, and Well-being
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
- Cardiac electrophysiology and arrhythmias
- Respiratory Support and Mechanisms
- Bacteriophages and microbial interactions
- Heart Failure Treatment and Management
- Biomedical and Engineering Education
- Diabetes Treatment and Management
- Coronary Artery Anomalies
- Heart rate and cardiovascular health
- Cardiac Health and Mental Health
- Autism Spectrum Disorder Research
- Medical Practices and Rehabilitation
- Neuroendocrine Tumor Research Advances
- Corporate Governance and Law
- Leadership, Human Resources, Global Affairs
- Viral gastroenteritis research and epidemiology
- Urinary Tract Infections Management
Johns Hopkins University
2020-2024
University of Siena
2021
Johns Hopkins Center for Health Security
2021
Stanford University
2019
Klinikum Magdeburg
2014
Introduction The Global Health Security Index benchmarks countries’ capacities to carry out the functions necessary prevent, detect and respond biological threats. COVID-19 pandemic served as an opportunity evaluate whether contained correct array of variables that influence abilities these threats; assess additional may preparedness; examine how impact preparedness components change during public health crises. Methods Linear regression models were examined determine relationship between...
Human challenge trials (HCTs) have been proposed as a means to accelerate SARS-CoV-2 vaccine development. We identify and discuss 3 potential use cases of HCTs in the current pandemic: evaluating efficacy, converging on correlates protection, improving understanding pathogenesis human immune response. outline limitations find that are likely be most useful for candidates currently preclinical stages conclude that, while limited their application, there scenarios which would extremely...
Affordable and accurate nucleic acid synthesis is foundational to modern biotechnology, but raises security concerns because it facilitates the construction of pathogens other potentially dangerous biological agents. Nucleic screening can reduce risk providing harmful acids those without a legitimate use for them. Governments, industry associations, biosecurity organizations have offered guidance on decade, are now considering how translate best practices into regulatory frameworks.
In human challenge trials (HCTs), volunteers are deliberately infected with an infectious agent. Such can be used to accelerate vaccine development and answer important scientific questions. Starting early in the COVID-19 pandemic, ethical concerns were raised about using HCTs approval of a vaccine. Some those pertained potential exploitation and/or lack truly informed consent from volunteers. Specific areas concern arose around individuals who may unusually risk-seeking or too economically...
Research suggests that children with autism spectrum disorder (ASD) may have reduced empathy, as measured by an impaired contagious yawn response, compared to typically developing (TD) children. Other research has failed replicate this finding, instead attributing phenomenon group differences in attention paid stimuli. A third possibility is only a subgroup of ASD exhibits the and it can be identified biologically. Here we quantified blood concentrations “social” neuropeptide oxytocin (OXT)...
Abstract In human challenge trials, volunteers are deliberately infected with a pathogen to accelerate vaccine development and answer key scientific questions. the U.S., preparations for trials novel coronavirus complete, in U.K., have recently begun. However, ethical concerns been raised about potential invalid consent or exploitation. These largely reflect worries that trial may be unusually risk-seeking too economically vulnerable refuse payments these provide, rather than being motivated...
Background: Pandemics caused by novel pathogens produce devastating global effects. Early detection is critical, and the International Health Regulations (2005) (IHR[2005]) require countries to report outbreaks of unknown causes. However, extent disease surveillance unclear. Establishing baseline information vital for guiding new preparedness initiatives like Pandemic Treaty. This study aimed determine number that consider diseases in their national public health infrastructure.Methods: We...
This project aims to develop an evidence based clinical guideline for the rehabilitation of cardiac patients considering recent scientific literature (stage 1), procedures received by undergoing carried German Federal Insurance Institute Salaried Employees (BfA) on Classification Therapeutic Procedures (KTL) 2), and expert agreement professionals involved 3). study presents results stage 2. The analysis KTL-statistics was out determine whether it is essentially necessary implement a define...
Recently, human challenge trials (HCTs) have been proposed as a means to accelerate the development of an effective SARS-CoV-2 vaccine. In this paper, we discuss potential role for such studies in current COVID-19 pandemic. First, present three scenarios which HCTs could be useful: evaluating efficacy, converging on correlates protection, and improving understanding pathogenesis immune response. We go outline practical limitations these scenarios. conclude that, while currently limited their...