A5004436093- Analytical Chemistry and Sensors
- Advanced Sensor and Energy Harvesting Materials
- Gas Sensing Nanomaterials and Sensors
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Nanopore and Nanochannel Transport Studies
- Membrane-based Ion Separation Techniques
- Sensor Technology and Measurement Systems
- Acoustic Wave Resonator Technologies
École Polytechnique Fédérale de Lausanne
2012-2019
Wearable systems could offer noninvasive and real-time solutions for monitoring of biomarkers in human sweat as an alternative to blood testing. Recent studies have demonstrated that the concentration certain can be directly correlated their concentrations blood, making a trusted biofluid candidate diagnostics. We introduce fully on-chip integrated wearable sensing system track biochemical information at surface skin real time. This heterogeneously integrates, on single silicon chip,...
In the past decade, a number of single-molecule methods have been developed with aim investigating single protein and nucleic acid interactions. For first time we use solid-state nanopore sensing to detect E. coli RNAP–DNA transcription complex RNAP enzyme. On basis their specific conductance translocation signature, can discriminate identify between those two types molecular translocations bare DNA. This opens up new perspectives for processes at level.
Ion sensitive field effect transistors (ISFETs) form a very attractive solution for wearable sensors due to their capacity ultra-miniaturization, low power operation, and high sensitivity, supported by complementary metal oxide semiconductor (CMOS) integration. This paper reports the first time, multianalyte sensing platform that incorporates performance, yield, robustness, three-dimensional-extended-metal-gate ISFETs (3D-EMG-ISFETs) realized postprocessing of conventional 0.18 μm CMOS...
This paper reports a novel fully integrated low power multi-sensing smart system, which, by wafer-level 3D heterogeneous integration of Ion Sensitive Fully Depleted (FD) FETs and SU-8 micro/nanofludics, achieves the first its kind wearable called Lab on Skin <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> , capable to detect biomarkers in human sweat. In reported configuration, system exploits arrays functionalized sensors...
This paper reports for the first time, smart 3D-Extended-Metal-Gate Ion-Sensitive-Field-Effect-Transistors (3D-EMG-ISFETs), with unique figures of merit: (i) extremely-low-power (down to a record value 2 pW per sensor under excellent linearity), (ii) all CMOS integrated, (iii) high performance pH and multi-ion (Na <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> , K Ca xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> ) sensing, and,...
This work presents one of the first low power pH sensing microfluidic chip based on heterogeneous integration of: (i) high-k FinFET sensors with liquid gate, (ii) miniaturized Ag/AgCl quasi-Reference Electrode and (iii) passive microfluidic. The these three components provides a fully integrated compact platform that could be exploited for ionic monitoring in biofluids healthcare applications. We describe full fabrication process system embedded reference electrode. electrical...
This paper presents a method to integrate biocompatible passive microfluidic systems within sensing platform allow continuous analysis of sweat in wearable microsystem. The technology is promising for miniaturization enable access biochemical information at the surface human skin. microfluidics are originally designed work with ultra-low volumes liquid any physiological situation (during intense physical activity or when rest). Flow rates vary from 10s 100s pico-liters per second which can...
Over the past few decades, Ion Sensitive Field Effect Transistor (ISFET) has been fabricated using a variety of technologies [1] based on idea an ion-sensitive gate. In effort to bring ISFETs into Point-of-Care applications and wearable products [2], their compatibility with industrial CMOS processes is crucial for realizing miniaturized integrated sensor system. The challenges are high, knowing that it very difficult change any processing steps in established Front-End-of-the-Line....