A5056872076- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Trypanosoma species research and implications
- Cutaneous lymphoproliferative disorders research
- Immunodeficiency and Autoimmune Disorders
- Research on Leishmaniasis Studies
Charité - Universitätsmedizin Berlin
2016-2024
Humboldt-Universität zu Berlin
2016-2019
Freie Universität Berlin
2018-2019
Triple-negative breast cancer (TNBC) corresponds to approximately 20% of all tumors, with a high propensity for metastasis and poor prognosis. Because TNBC displays mutational load compared other types, neoantigen-based immunotherapy strategy could be effective. One major bottleneck in the development vaccine is selection best targets, that is, tumor-specific neoantigens which are presented at surface tumor cells capable eliciting robust immune responses. In this study, we aimed set up...
Macrophages are specialized antigen-presenting cells that process and present self-antigens for induction of tolerance, foreign antigens to initiate T cell-mediated immunity. Despite this, Leishmania donovani (LD) able parasitize the macrophages persist. The impact this parasitizing persistence on antigen processing presentation by remains poorly defined. To gain insight into we analyzed liquid chromatography tandem mass spectrometry (LC-MS/MS) compared HLA-I self-peptidomes, proteasome...
Abstract Dendritic cells (DCs) and macrophages are specialized APCs that process present self-Ags for induction of tolerance foreign Ags to initiate T cell–mediated immunity. Related differentiation states they have specific phenotypes functions. However, the impact these differentiations on Ag processing presentation remains poorly defined. To gain insight into this, we analyzed compared HLA-I peptidomes MUTZ3-derived human immature mature DC lines THP1-derived by liquid chromatography...
Abstract Leukemia-associated antigens (LAAs) and HLA-I epitopes published previously have shown promise in inducing leukemia-specific T cell responses. However, the clinical responses are limited, effectiveness is yet to be achieved. Limitations, among others, being LAAs themselves, indirect approach epitope identification by reverse immunology, use of single or few epitopes, which limits spectrum inducible tumor-specific cells. Use a direct identify naturally processed presented from LAAs,...
Sezary syndrome (SS) is a rare and aggressive form of cutaneous T–cell lymphoma, that has poor prognosis, with median overall survival time less than 3 years. Despite advances in its treatment, SS challenge to manage, often characterized by high rates relapse limited response therapy many patients. The main for including vaccine development heterogeneity. In molecular genetic characteristics, clinical presentation, disease progression, treatment response. Understanding the heterogeneity at...