A5057531794- Genomics and Phylogenetic Studies
- Malaria Research and Control
- Bacteriophages and microbial interactions
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Evolution and Genetic Dynamics
- Species Distribution and Climate Change
- Plant Virus Research Studies
- Computational Drug Discovery Methods
Istanbul University
2024
Wellcome Sanger Institute
2024
Monitoring the genomic evolution of Plasmodium falciparum - most widespread and deadliest human-infecting malaria species is critical for making decisions in response to changes drug resistance, diagnostic test failures, vaccine effectiveness. The MalariaGEN data resources are world’s largest whole genome sequencing databases parasites. size complexity such a barrier many potential end users both public health academic research. A user-friendly method accessing interpreting on genetic...
Abstract Artemisinin partial resistance (ART-R) in Plasmodium falciparum is one of the most pressing threats to global malaria control. Over last two decades, ART-R has spread widely across Southeast Asia, compromising public health strategies and hindering elimination efforts. As 2024, now emerged East Africa, with potential dramatically increase human mortality region. Mitigating requires detailed genomic surveillance point mutations kelch13 gene, primary determinant artemisinin...
Abstract Sequence diversity is one of the major challenges in design diagnostic, prophylactic, and therapeutic interventions against viruses. DiMA a novel tool that big data-ready designed to facilitate dissection sequence dynamics for stands out from other analysis tools by offering various unique features. provides quantitative overview (DNA/RNA/protein) use Shannon’s entropy corrected size bias, applied via user-defined k-mer sliding window an input alignment file, each position dissected...
Abstract Motivation Monitoring the genomic evolution of Plasmodium falciparum—the most widespread and deadliest human-infecting malaria species—is critical for making decisions in response to changes drug resistance, diagnostic test failures, vaccine effectiveness. The MalariaGEN data resources are world’s largest whole genome sequencing databases parasites. size complexity such is a barrier many potential end users both public health academic research. A user-friendly method accessing...
Sequence diversity is one of the major challenges in design diagnostic, prophylactic and therapeutic interventions against viruses. Herein, we present DiMA, a tool designed to facilitate dissection sequence dynamics for As base, DiMA provides quantitative overview by use Shannon's entropy, applied via user-defined k-mer sliding window an input alignment file. Distinctively, key feature that interrogates dissecting each position various motifs, defined based on incidence distinct sequences....