A5071745873- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chemical Synthesis and Characterization
- Coronary Interventions and Diagnostics
- Adolescent and Pediatric Healthcare
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood donation and transfusion practices
- Epilepsy research and treatment
- Hospital Admissions and Outcomes
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- Minimally Invasive Surgical Techniques
- Mobile Health and mHealth Applications
- Potassium and Related Disorders
- Surgical Simulation and Training
- Mechanical Circulatory Support Devices
- Hernia repair and management
- Lipoproteins and Cardiovascular Health
Vanderbilt University Medical Center
2018-2025
Vanderbilt Health
2020-2024
May Institute
2019
Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in United States, although nonalcoholic steatohepatitis (NASH) on rise. Increasingly effective HCV antivirals are available, but their association with diagnosis-specific rates and early graft survival not known.The Scientific Registry of Transplant Recipients database records were retrospectively stratified by antiviral era: interferon (2003-2010), protease inhibitors (2011-2013), direct-acting (2014 to...
Background. A major change to deceased-donor kidney allocation in the United States, Kidney Allocation System 250 (KAS250), was implemented on March 15, 2021. Evaluating consequences of this policy critical system performance metrics is determining its success. Methods. We performed a retrospective analysis measures transplant by reviewing all organs procured during 4-y period States. To mitigate against possible effects COVID-19 pandemic, Scientific Registry Transplant Recipients records...
Despite the divergent disease biology of cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC), wait-list prioritization is identical for both diagnoses. We compared posttransplant outcomes between CCA HCC liver transplantation patients with Model End-Stage Liver Disease exceptions using Scientific Registry Transplant Recipients data. The 408 candidates listed 2003 mid-2017 were matched to 2 cohorts by listing date (±2 months, n = 816) Organ Procurement Transplantation Network (OPTN)...
Abstract Introduction Data on long‐term outcomes following A2/A2B to B kidney transplants since the 2014 allocation system (KAS) changes are few. The primary aim of this study is report our 7‐year experience with and compare post‐transplant a concurrent group transplants. Additionally, evaluates impact pre‐transplant anti‐A1 titers survival in Methods This retrospective, single‐center analysis included all adults who received deceased donor from December June 2021 compared recipients....
Societal factors that influence wait-listing for transplantation are complex and poorly understood. Social determinants of health (SDOH) affect rates outcomes after transplantation.This cross-sectional study investigated the impact SDOH on additions to state-level, 2017-2018 kidney liver wait-lists. Principal components analysis, starting with 127 variables among 3142 counties, was used derive novel, comprehensive state-level composites, designated (1) health/economics (2) community...
Transplantation of hepatitis C viremic (HCV+) deceased donor kidney transplants (DDKT) into aviremic (HCV-) recipients is a strategy to increase organ utilization. However, there are concerns around inferior recipient outcomes due delayed initiation direct-acting antiviral (DAA) therapy and sustained HCV replication when implemented outside research setting.This was retrospective single-center matched cohort study DDKT HCV+ donors (cases) who were 1:1 HCV- (comparators) by age, gender, race,...
The United Network for Organ Sharing recently altered current liver allocation with the goal of decreasing Model End-Stage Liver Disease (MELD) variance at transplant. Concerns over these and further planned revisions to policy include predicted decrease in total transplants, increased flying logistical complexity, adverse impact on areas poor quality health care, minimal effect high MELD donor service areas. To address issues, we describe general approaches equalize critical transplant...
The 2014 pancreas allocation system (PAS) intended to decrease geographic variability in listing practices for simultaneous and kidney (SPK) transplant define eligibility criteria those with type 2 diabetes mellitus (T2DM). Our primary aims were evaluate disparities access SPK assess T2DM listings the pre- post-PAS eras.Adult (pre-PAS, January 2010 October 29, 2014; post-PAS, 30, 2014, June 2, 2017) identified Scientific Registry of Transplant Recipients. Multivariable logistic regression...
Background As the organ-shortage crisis continues to worsen, many patients in need of a kidney transplant have turned social media find living donor. The effect on donation is not known. goal this study investigate influence those interested donating kidney. Methods Self-referrals for from December 2016 March 2019 were retrospectively reviewed. Age, sex, race, and relationship individuals petitioned through (SM) compared with verbal communication (VC). Data analyzed using chi-squared tests,...
Abstract Background The United Network for Organ Sharing system allocates deceased donor kidneys based on the kidney profile index ( KDPI ), stratified as sequences (A ≤ 20%, B > 20‐<35%, C ≥ 35‐≤85%, and D 85%), with increasing associated decreased graft survival. While health‐related quality of life HRQOL ) may improve after transplantation, effect quality, reflected by sequence, post‐transplant has not been reported. Methods Health‐related was measured using eight scales physical...
While liver transplantation (LT) with neoadjuvant chemoradiation is increasingly utilized for the management of unresectable cholangiocarcinoma (CCA), data on post-LT survival are limited.We identified 844 patients who underwent LT (2002-2019) nonincidental (CCA listing) or incidental explant, not at CCA in Scientific Registry Transplant Recipients. Kaplan-Meier and multivariable proportional hazards regression methods evaluated effects patient characteristics, donor type, transplant era...
Characteristics of incisional hernia (IH) formation after live donor nephrectomy (LDN) are not well-defined. The goal this study was to describe the incidence IH within 3 years LDN and identify risk factors contributing their formation.We performed a single-center, retrospective review all between February 2013 October 2018. Patients with without were compared based on operative variables. Data analyzed using chi-square tests column proportions. Multivariable logistic regression backward...
Previous studies of liver transplant recipients have reported discrepancies with regard to gender and/or sex differences but focused on pretransplant outcomes. Female candidates are less likely receive and more die or be delisted than their male counterparts. Here, we examined in men versus women alcoholic disease before the effects these posttransplant survival.We analyzed Scientific Registry Transplant Recipients records adult, deceased-donor, whole decompensated from 2002 2017 evaluate...
Abstract Introduction The COVID‐19 pandemic allowed for the rapid implementation of telemedicine kidney transplant patients; however, widespread adoption may worsen existing health care inequities among vulnerable populations. This study aimed to characterize utilization by patients during early with particular attention healthcare equity. Methods A retrospective analysis interacting was performed. Patient demographic data and distance center were obtained. National Center Health Statistics...
Utilization of hepatitis C viremic (HCV+) deceased donor kidneys (DDKT) for aviremic recipients increases opportunities transplantation with excellent short-term outcomes. Our primary aim was to understand longer-term outcomes, specifically assessing kidney and liver function in the first year posttransplant.