A5065854222- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced Sensor and Energy Harvesting Materials
- Advanced Memory and Neural Computing
- Advanced MEMS and NEMS Technologies
- Semiconductor Lasers and Optical Devices
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- ATP Synthase and ATPases Research
- Analytical Chemistry and Sensors
- Nanofabrication and Lithography Techniques
- 3D IC and TSV technologies
- Conducting polymers and applications
- Photoreceptor and optogenetics research
- Hydrogels: synthesis, properties, applications
- Semiconductor materials and devices
- Advanced Electron Microscopy Techniques and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Electrowetting and Microfluidic Technologies
- Advancements in Transdermal Drug Delivery
- Mechanical and Optical Resonators
- Cardiomyopathy and Myosin Studies
- Silicon Carbide Semiconductor Technologies
- Dermatology and Skin Diseases
Faculdade de Ciências Médicas de Minas Gerais
2021
Uppsala University
2010-2018
Fundação Oswaldo Cruz
2018
IMEC
2007-2014
Imec the Netherlands
2013
KU Leuven
2007-2010
University of Freiburg
2009
University of California, Los Angeles
2003-2004
Cornell University
1993-2002
Philips (United States)
1998
Biomolecular motors such as F 1 –adenosine triphosphate synthase (F -ATPase) and myosin are similar in size, they generate forces compatible with currently producible nanoengineered structures. We have engineered individual biomolecular nanoscale inorganic systems, we describe their integration a hybrid nanomechanical device powered by motor. The consisted of three components: an substrate, -ATPase motor, fabricated nanopropellers. Rotation the nanopropeller was initiated 2 mM adenosine...
This paper presents a pseudo-2-D surface potential model for the double-gate tunnel field-effect transistor (DG-TFET). Analytical expressions are derived 2-D potential, electric field, and generation rate, used to numerically extract tunneling current. The predicts device characteristics large range of parameters allows gaining insight on physics. depletion regions induced inside source drain included in solution, we show that these become critical when scaling length. fringing field effect...
This work presents a new fabrication technology for silicon-based neural probe devices and their assembly into two-dimensional (2D) as well three-dimensional (3D) microprobe arrays recording. The is based on robust double-sided deep reactive ion etching of standard silicon wafers allows full 3D control the geometry. Wafer level electroplating gold pads was performed to improve platform. Lithography-based probe-tracking features quality management were introduced. Probes two different...
This paper reports on a novel high-density CMOS-based silicon microprobe array for intracortical recording applications. In contrast to existing systems, CMOS multiplexing units are integrated directly the slender, needle-like probe shafts. Single-shaft probes and four-shaft combs have been realized with 188 752 electrodes, respectively, pitch of 40 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex...
This paper presents multi-electrode arrays for in vivo neural recording applications incorporating the principle of electronic depth control (EDC), i.e., selection sites along slender probe shafts independently multiple channels. Two-dimensional (2D) were realized using a commercial 0.5- μm complementary-metal-oxide-semiconductor (CMOS) process EDC circuits combined with post-CMOS micromachining to pattern comb-like probes and corresponding electrode metallization. A dedicated CMOS...
Calibrated density measurements have been obtained of the coronal plasmas around exploding 7.5–40 μm W wires carrying 15–120 kA per wire for 30–70 ns. X-ray radiographs using 2.5–10 keV photons from a Mo X-pinch backlighter enabled areal densities ranging 2×1017/cm2, equivalent to 0.03 solid W, about 1019/cm2. The rapidly expanding (few mm/μs) surrounding slowly (&lt;1 residual cores up 2×1018/cm2. Single 7.5 tested with 100 had as much 90% initial material in plasma. Coronal plasma...
This paper reports on the characterization and intracortical recording performance of high-density complementary-metal–oxide–semiconductor (CMOS)-based silicon microprobe arrays. They comprise multiplexing units integrated probe shafts being part signal transmission path. Their electrical reveals a negligible contribution electrode impedances <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX"> $139 \pm...
This paper reports on the design, fabrication, assembly and characterization of a three-dimensional silicon-based floating microprobe array for localized drug delivery to be applied in neuroscience research. The is composed silicon platform into which up four probe combs with needle-like shafts can inserted. Two dedicated positions allow integration delivery. implemented comb variants feature 8 mm long two individually addressable microchannels incorporated single shaft or distributed...
Recording simultaneous activity of a large number neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the vivo performance recently developed electrophysiological recording system comprising two-dimensional, multi-shank, high-density silicon probe with integrated complementary metal-oxide semiconductor electronics. The implements concept electronic depth control (EDC), which enables selection limited sites on each shafts. This...
An out-of-plane interconnect system has been developed for biomedical microprobes. With this type of interconnect, different microelectromechanical (MEMS) structures can be electrically and mechanically connected perpendicular to a backbone. The probes backbone are processed separately which enables modular approach. MEMS inserted into cavities (which act as sockets) the electrical contact is established by means overhanging gold clips bent squeezed between cavity wall upon insertion....
Recordings from the brain have been used for decades to investigate activity of individual neurons. However, complex interaction between electrical and chemical signals with respect short long term changes morphology information transfer is still poorly understood. We introduce a new modular approach multifunctional probe arrays cerebral applications that will enable addressing fundamental questions in neuroscience. Our allows assembly multiple probes customized architecture into...
Abstract It is an uninformative truism to state that the brain operates at multiple spatial and temporal scales, each with own set of emergent phenomena. More worthy attention point our current understanding it cannot clearly indicate which these phenomenological scales are significant contributors brain’s function primary output (i.e. behaviour). Apart from sheer complexity problem, a major contributing factor this affairs lack instrumentation can simultaneously address without causing...
The ability to precisely position and orient biological molecules on engineered substrates is an enabling technology critical the long-term goal of integrating biomolecular motors with nano-electro-mechanical systems. Electron beam lithography nanoimprinting techniques were used produce arrays nickel dots (50−200 nm diameter). Analysis using fluorescence (of microspheres attached γ subunit) atomic force microscopy these demonstrated precise positioning, spacing, orientation individual...
This paper reports on a novel CMOS-based high-density silicon microprobe array for intracortical recording applications. In contrast to existing systems, CMOS multiplexing units are integrated the slender, needle-like probe shaft 160 μm in width. present implementation an unequaled number of 188 electrodes (diameter 20 μm, pitch 40 μm) arranged two columns along 4-mm-long shaft. The on-shaft integration electronics is motivated by requirement discriminate single action potentials...
This paper introduces the first experimental results of a new implantable slim-base three-dimensional (3D) probe array for cerebral applications. The probes are assembled perpendicularly into readout platform where electrical and mechanical connections achieved simultaneously. A type micromachined interconnect has been developed to establish connection using extreme planarization techniques. Due modular approach platform, arrays different dimensions functionality can be assembled. is only...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Inchworm microactuators are popular in micropositioning applications for their long ranges. However, until now, they could not be considered such as <emphasis emphasistype="boldital">in vivo</emphasis> biomedical because of high input voltages. This paper reports on the modeling, design, fabrication, and testing a new family pull-in-based electrostatic inchworm which provides solution to this...
This paper presents the NeuroSelect software for managing electronic depth control of cerebral CMOS-based microprobes extracellular in vivo recordings. These contain up to 500 electronically switchable electrodes which can be appropriately selected with regard specific neuron locations course a recording experiment. makes it possible scan and (re)select those best signal quality resulting closed-loop design neural acquisition system. The is calculated by relative power spikes compared...
The European project NeuroProbes has introduced a new methodology to allow the fine positioning of electrodes within an implantable probe with respect individual neurons. In this approach, probes are built very large number which electronically selectable. This feature is implemented thanks modular approach adopted in NeuroProbes, will implementation integrated electronics both along shaft and on array backbone.
A compressible multifunctional interconnect for out-of-plane MEMS structures has been fabricated using a thin film transfer bonding technique and bio-tolerable materials. The bulk material of the stretchable consists photo-patternable poly-dimethylsiloxane is on carrier substrate. bonded to slim-base platform. substrate released an aluminum anodic dissolution technique. Probe arrays can be assembled perpendicularly into Once probes are non-separable electrical connection established.
Selective copper encapsulation on silicon has been used to fabricate micromachined devices such as inductors with quality factors over 30 at frequencies above 5 GHz. The are fabricated using either polysilicon surface micromachining, or integrated and deep reactive ion etching bulk micromachining. Their exposed surfaces selectively activated by palladium activation, which allows the subsequent deposition only. This encapsulated-with-copper technique takes advantage of both excellent...