A5097820832- Epigenetics and DNA Methylation
- Immune cells in cancer
- Single-cell and spatial transcriptomics
Instituto Nacional do Câncer
2023-2024
Abstract Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different types, identifying 29 MDC subpopulations within the tumor microenvironment. Our analysis reveals abnormally expanded across various tumors distinguishes cell states that have often been grouped together, such as TREM2+ FOLR2+ subpopulations. Using...
Abstract Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment response due to their remarkable plasticity tumorigenic behaviors. We integrated single-cell RNA-Sequencing datasets from seven different cancers, resulting in a comprehensive collection of 29 MDC subpopulations the tumor microenvironment (TME). Distinguishing resident-tissue monocyte-derived macrophages, we discovered resident-tissue-like subpopulation within macrophages. Additionally,...