A5034827446- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammatory Bowel Disease
- Spondyloarthritis Studies and Treatments
- Blood Pressure and Hypertension Studies
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Immunology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Heart Rate Variability and Autonomic Control
- SARS-CoV-2 and COVID-19 Research
- Ultrasound in Clinical Applications
- Immunodeficiency and Autoimmune Disorders
- HER2/EGFR in Cancer Research
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- Microscopic Colitis
- Intestinal Malrotation and Obstruction Disorders
- Musculoskeletal pain and rehabilitation
- Autoimmune and Inflammatory Disorders
- Ultrasound and Hyperthermia Applications
- Hepatitis C virus research
- Lymphoma Diagnosis and Treatment
Luigi Sacco Hospital
2011-2021
ASST Fatebenefratelli Sacco
2017-2021
Azienda Sanitaria Unità Locale di Reggio Emilia
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
University of Milan
1986-2020
Center for Rheumatology
2013-2015
University of Florence
2009
Interstitial lung disease (ILD) is a frequent extra-articular manifestation of RA associated with increased mortality. High-resolution CT (HRCT) used for diagnosis and follow-up, but its accuracy counterbalanced by high costs radiological risk. In the presence ILD, US (LUS) detects vertical artefacts called B-lines. The aims present study were to evaluate LUS in ILD validate use pocket-size device (PS-USD) as screening tool.LUS was performed standard equipment trained physician through...
Objective. To identify the determinants of anti-TNF-naive patients' preferences for route administration anti-TNF agents. Methods. The study was carried out in 50 Italian rheumatology centres (802 patients). All patients completed a 31-item questionnaire addressing their perceptions current treatment and with Statistical methods included analysis variance (ANOVA), t-test chi-square test. Results. response rate to 97.6%. At time survey, 310 (39.9%) were dissatisfied treatments, owing...
Clinical trials have shown that anti-tumour necrosis factor (TNF)-α drugs are effective in patients with rheumatoid arthritis (RA) refractory to disease- modifying antirheumatic (DMARDs) (1-4). At about the same time as European approval of third anti-TNFα agent (adalimumab) for treating RA patients, Italian Society Rheumatology (Società Italiana di Reumatologia [SIR]) started a database registration and active follow-up treated biological response modifiers, which contains all demographic...
Background The close relationship between joints and gut inflammation has long been known several data suggest that dysbiosis could link spondyloarthritis (SpA) to inflammatory bowel diseases (IBD). introduction of biological drugs, in particular tumour necrosis factor inhibitors (TNFi), revolutionised the management both these diseases. While impact conventional drugs on microbiota is well known, poor are available about TNFi. Aim To investigate TNFi microbiota. Methods We evaluated 20...
Inflammatory bowel diseases (IBDs), particularly Crohn's disease (CD) and ulcerative colitis (UC), are associated with a variety of extra-intestinal manifestations (EIMs). About 36% IBD patients have at least one EIM, which most frequently affect the joints, skin, eyes biliary tract. The EIMs negative impact on UC CD, resolution them parallels that active in terms timing required therapy; however, clinical course such as axial arthritis, pyoderma gangrenosum, uveitis, primary sclerosing...
Background . The aim of our study was to evaluate the serum concentration klotho in a cohort systemic sclerosis (SSc) patients compared that healthy controls and correlate its levels with degree kind organ involvement. Methods Blood samples obtained from both were collected analysed by an ELISA test for determination human soluble klotho. Scleroderma evaluated disease activity through clinical, laboratory, instrumental assessment. Results Our consisted 81 SSc (74 females, mean age 63.9 ±...
<h3>Background</h3> Rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, safe and effective in rheumatoid arthritis (RA) patients with inadequate response orintolerant to tumor necrosis factor (TNF) inhibitorshas been approved at dose of 1g fortnightlyevery six months. The SERENA MIRROR studies have shown that rates are similar treated 2x0.5g 2x1g every months, but there is no agreement concerning the optimal RTX strategy over time (1.2). <h3>Objectives</h3> To verify whether RA...
Background Biosimilar infliximab (INX) was recently approved by the European Medicine Agency based on comparable pharmacokinetics, safety and efficacy profile to innovator INX for treatment of Rheumatoid Arthritis, Ankylosing Spondylitis (AS), Crohn9s disease, Ulcerative Colitis, Psoriatic Arthritis (PsA), psoriasis. (1) Switching from biosimilar offers cost savings but, up now, limited evidence (from conference abstracts open-label extension studies suggesting similar clinical efficacy) no...
Klotho is a transmembrane and soluble glycoprotein that governs vascular integrity. Previous studies have demonstrated reduced serum klotho concentrations in patients with systemic sclerosis (SSc), it known deficiency can impair the healing of digital ulcers related to microvessel damage. The aim this study was evaluate association between levels nailfold capillaroscopic abnormalities SSc patients. We retrospectively enrolled 54 consecutive diagnosed on basis 2013 EULAR/ACR criteria [11...
<h3>Background</h3> Despite concerns regarding its accuracy and reliability, Wikipedia is increasingly being used by medical students as a source of information (1,2). <h3>Objectives</h3> Aim our study was to evaluate whether rheumatology articles could represent reliable for students. <h3>Methods</h3> Our analyzed available on the English database (http://en.wikipedia.org). From International Classification Diseases (ICD-10), 283 rheumatologic codes were identified, mainly but not...
To assess the efficacy and tolerability of metoprolol (MET), 200 mg slow release (SR) q.d., nifedipine (NIF), 20 SR b.i.d., mildly to moderately hypertensive outpatients (14 men 6 women; mean age 41.5 years, range 27-49 years) were studied. After being withdrawn from previous antihypertensive treatments, patients given single-blind placebo for 2 weeks thereafter, in double-blind, randomized sequence, MET NIF, both weeks. At end each period study, blood pressure (BP) was recorded 24 h using a...
Leading scientists and influential professional societies have been warning of the dangers emerging infections threat a global pandemic for years, but nobody imagined that new decade would open with most significant public health challenge our lives. The emergence subsequent spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has surpassed many expectations as evolving economic crisis continues to change personal Although disease started in China December 2019, 27 March 2020...