A5028979214- Poisoning and overdose treatments
- Pharmacovigilance and Adverse Drug Reactions
- Silymarin and Mushroom Poisoning
- Plant-based Medicinal Research
- Pharmacological Effects and Toxicity Studies
- Vagus Nerve Stimulation Research
- Nicotinic Acetylcholine Receptors Study
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical studies and practices
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
- Antibiotics Pharmacokinetics and Efficacy
- Bee Products Chemical Analysis
- Pharmaceutical Practices and Patient Outcomes
- Drug-Induced Adverse Reactions
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Art Therapy and Mental Health
- Heme Oxygenase-1 and Carbon Monoxide
- Electroconvulsive Therapy Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Plant Toxicity and Pharmacological Properties
- Education Practices and Challenges
- Takotsubo Cardiomyopathy and Associated Phenomena
- Creative Drama in Education
Dokuz Eylül University
2015-2025
Istanbul University-Cerrahpaşa
2024
Istanbul Medipol University
2024
Adnan Menderes University
2012
The aim of this study was to analyse the caustic and household detergent exposure cases were admitted Department Emergency Medicine at Dokuz Eylul University Hospital (EMDEU) between 1993 2008.Age, sex, reason exposure, clinical signs, rate endoscopy in oral exposures, treatment attempts, length hospital stay outcome evaluated. A chi-square test used statistical differences.Caustic exposures accounted for 8.5% (1160 cases) 4.1% (1988 all poisonings children adults, respectively. Female/male...
The aim of this study was to evaluate the short and long-term impact pharmacovigilance (PV) training on 5th year medical students' knowledge about definitions awareness regulatory aspects in PV.In academic 2010/11, students completed structured, questionnaire before just after training. They also same 1-year training.The PV significantly increased term (P < 0.001). However, improvement decreased Although scores were higher than baseline score, difference not statistically significant. Total...
Introduction: The purpose of this study is to delineate anti-inflammatory and antioxidant potential varenicline, a cigarette smoking cessation aid, on decreasing lipopolysaccharide (LPS)-elevated proinflammatory cytokines in RAW 264.7 murine macrophage cultures which we showed earlier occur via cholinergic pathway (CAP) activation. To end, investigated the possible suppressive capacity varenicline LPS-regulated cyclooxygenase (COX-1 COX-2) α7 nicotinic acetylcholine receptor (α7nAChR)...
Neuroleptic malignant syndrome (NMS) is a neurological emergency rarely encountered in clinical practice but with high mortality rate. Cases associated atypical antipsychotic use or termination of dopamine agonists have been seen recent years. The purpose this study was to assess the presence risk factors for by investigating all and laboratory characteristics cases NMS.This descriptive, cross-sectional retrospectively investigated scanning ICD-10 codes patients presenting XXXX Faculty...
<b>Objectives:</b> In this study we aimed to evaluate the impact of Rational Pharmacotherapy (RPT) course program, reinforced by video footages, on rational pharmacotherapy skills students. <br><b>Materials and Methods:</b> RPT program has been conducted in Dokuz Eylul University School Medicine since 2008/9. The organised accordance with World Health Organisation (WHO) Good Prescribing Guide. aim was improve problem solving (methodology for selection (p)ersonel-drug, prescription writing...
The cholinergic anti-inflammatory pathway plays an important role in controlling inflammation. This study investigated the effects of varenicline, α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on inflammatory cytokine levels, cell proliferation, and migration rates a lipopolysaccharide (LPS)-induced inflammation model RAW 264.7 murine macrophage lines. cells were treated with increasing concentrations followed by LPS incubation for 24 h. Prior to receptor-mediated events,...
The purpose of this study is to investigate the effects cholinergic anti-inflammatory pathway (CAP)-activating drugs, choline and citicoline (Cytidinediphosphate-choline, CDP-choline), on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) parameters contribution NADPH Oxidase4 (NOX4) p22phox.Endotoxemia induces a systemic inflammatory response characterized by production pro-inflammatory mediators reactive oxygen species (ROS), which eventually develops (AKI). p22phox contributes...
Abstract: P‐glycoprotein (P‐gp) is expressed in tumour cells as well normal tissues including heart. Modulation of P‐gp transport vivo may lead to increased drug penetrance with resulting increases toxicity. We aimed investigate the effects on isolated heart by digoxin infusion absence and presence verapamil. The study was performed Langendorff perfused rat hearts. After a 20 min. stabilisation period Tyrode Buffer, (125 μg/5 mL) infused for 10 control group (n = 7). same dose during...
Abstract Amanita phalloides species mushrooms containing alpha‐amanitin (α‐ AMA ) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity acute hepatic failure. Existing antidotes, such as silibinin, not sufficiently effective prevention and/or resolution α‐ ‐induced hepatotoxicity. We investigated effects resveratrol on compared with a known antidote using vivo vitro toxicity models. In protocol, (30 mg/kg) was given...
Alpha-amanitin (α-AMA), the primary toxin of Amanita phalloides, is known to cause nephrotoxicity and hepatotoxicity. Resveratrol an antioxidant that has shown efficacy in many models. The aim this study was investigate effects resveratrol against early late stages α-AMA-induced nephrotoxicity, compared those silibinin, a well-known antidote for poisoning by α-AMA-containing mushrooms. Mice kidney tissues were obtained from five groups: (1) α-AMA + NS (simultaneous administration normal...
We planned this study in order to investigate the effects of theophylline on cardiovascular parameters an anaesthetized rat model amitriptyline toxicity. In preliminary study, we tested as 1 mg/kg bolus, followed by a 0.5-mg/kg infusion. Toxicity was induced infusion 0.94 mg/kg/min up point 40–45% inhibition mean arterial pressure (MAP). The rats were randomized two groups: group 5% dextrose bolus infusion, and another with Amitriptyline caused significant decrease MAP prolongation QRS;...
We aimed to evaluate adverse drug reaction (ADR)-related emergency department (ED) visits in the ED of Dokuz Eylül University Hospital prospectively.Patients who were admitted during 1-week periods four different seasons between July 2010 and April 2011 enrolled. Demographics patients, previous ADR history, clinical progress, outcomes recorded. Causality assessment was done according World Health Organization Uppsala Monitoring Centre categories. ADRs categorized as certain, probable, or...
This study was designed to evaluate the renoprotective effect of insulin on diabetic nephropathy through Rac1 inhibition. Twenty Wistar rats were divided into three groups: control (C), (D), and insulin-treated (D + I). Diabetes induced by a single streptozotocin (STZ) injection (45 mg/kg i.p.) in adult male rats. Diabetic animals treated subcutaneously with (6 U/kg), or saline once day for 8 weeks. Age-matched received only saline. The kidney tissue samples analyzed immunohistochemical...
Methyl bromide (CH3Br) is a halogenated aliphatic hydrocarbon that may cause acute and chronic toxicities. We describe case of 44-year-old male patient who developed toxic brain syndrome (TBS) central nervous system (CNS) toxicity after exposure to CH3Br by inhalation. Toxicity began with progressive nervousness, dysarthria coordination disorder. The complaints on admission the hospital were speech defect, balance disorder, consciousness disorder involuntary movements. was treated...
Objective: The aims of the study were to compare risk levels exposed drugs during pregnancy with regard United States Food and Drug Administration (FDA), Australian Evaluation Committee (ADEC) Teratogen Information System (TERIS) categories, determine outcomes FDA category based decisions on course in pregnant women who applied Dokuz Eylul University (DEU) Teratogenity Service (TIS). Material Methods: In this cross-sectional study, 220 enrolled referred DEU TIS for a teratogenity evaluation...
Purpose: We analyzed the antipsychotic medication exposures’ distribution in typical and atypical exposures severity of clinical signs symptoms admitted to Department Emergency Medicine at Dokuz Eylul University EMDEU between 1993 2015.Methods: Demographics patients, type exposure, according reason, amount exposed antipsychotics, findings, length hospital stay, outcome patients were analyzed.Results: Among all adult poisonings EMDEU, 2.6% them due exposure medication. Most intentional 95.5%...
Nitrofurantoin is widely used in the prophylaxis of urinary-tract infections. The aim this study was to develop and characterize innovative transdermal formulations nitrofurantoin, increase patient compliance decrease adverse effects such as nausea vomiting which limit drug use long-term.Nitrofurantoin loaded microemulsion, gel (hydrogel, lipogel DMSO gel) film were prepared characterized via several parameters. Ex-vivo permeation studies performed determine amount permeated through rat...