A5033789977- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- Protease and Inhibitor Mechanisms
- Intraocular Surgery and Lenses
- Vasculitis and related conditions
- Retinal and Macular Surgery
- Traumatic Ocular and Foreign Body Injuries
- Infectious Diseases and Tuberculosis
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Corneal Surgery and Treatments
- Angiogenesis and VEGF in Cancer
- Retinal Development and Disorders
- Vascular Malformations Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Ocular Oncology and Treatments
- S100 Proteins and Annexins
King Saud University
2016-2025
King Saud Medical City
2022
King Abdulaziz University
2007-2019
King Abdulaziz Hospital
2004-2016
Al-Nasser University
2016
King Abdul Aziz University Hospital
2014
King Khaled Eye Specialist Hospital
2007
Centre Hospitalier Universitaire Sainte-Justine
2003
McGill University
2003
Université de Montréal
2003
Purpose: To determine prognostic factors in patients with Vogt–Koyanagi–Harada (VKH) disease who were treated high-dose corticosteroids. Methods: Retrospective analysis of 87 (174 eyes). Results: At presentation, there 53 initial-onset acute VKH and 34 chronic recurrent disease. Chronic presentation was significantly associated more severe anterior segment inflammation at as indicated by presence mutton-fat keratic precipitates, chamber reaction ≥2+, iris nodules posterior synechiae (p <...
To assess diabetic retinopathy prevalence and its risk factors in a society with type 2 diabetes epidemic using the Saudi National Diabetes Registry (SNDR).This is cross-sectional study patient's clinical data found SNDR base. A cohort of 50,464 patients aged ≥25 years were selected to for retinopathy.The overall 19.7%, where 9.1% have non-proliferative (NPDR), 10.6% proliferative (PDR) 5.7% macular oedema (ME). Duration age are most significant odds ratio (OR) 95% confidence interval (95%...
Background— Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)–2 promotes tumor angiogenesis, we investigated the role COX-2 proliferative retinopathy. Methods Results— We describe here that is induced retinal astrocytes human diabetic retinopathy, murine rat model retinopathy vivo, hypoxic vitro. Specific but not COX-1 inhibitors prevented intravitreal...
Abstract. Purpose: To study the effectiveness of mycophenolate mofetil (MMF) as first‐line therapy combined with systemic corticosteroids in acute uveitis associated Vogt–Koyanagi–Harada (VKH) disease. The outcomes this group were compared those another patients VKH disease who treated corticosteroid monotherapy or delayed addition immunomodulatory therapy. Methods: This prospective included 19 (38 eyes) diagnosed Results: mean follow‐up period was 27.0 ± 11.1 months (range 16–54 months)....
To investigate which matrix metalloproteinases (MMPs) are more likely to be involved in the angiogenic process proliferative diabetic retinopathy (PDR), we measured levels of MMPs vitreous fluid from patients with PDR and controls correlated these vascular endothelial growth factor (VEGF). Vitreous samples 32 24 nondiabetic were studied by mosaic multiplex enzyme-linked immunosorbent assay (ELISA), single ELISA, Western blot zymography analysis. Epiretinal membranes 11 immunohistochemistry....
Abstract Purpose To evaluate the effectiveness and safety of mycophenolate mofetil ( MMF ) as first‐line therapy combined with systemic corticosteroids in initial‐onset acute uveitis associated Vogt–Koyanagi–Harada VKH disease. Methods This prospective study included 38 patients (76 eyes). The main outcome measures were final visual acuity, corticosteroid‐sparing effect, progression to chronic recurrent granulomatous development complications, particularly ‘sunset glow fundus’. Results mean...
To investigate the referral patterns and diagnosis of uveitis in a university-based tertiary center Riyadh, Saudi Arabia.We retrospectively reviewed medical records 642 patients (1220 eyes).There were 295 (46%) males 347 (54%) female patients, with mean age 36.4 ± 16.1 years at presentation. Panuveitis was most common (47.1%), followed by anterior (36.8%), posterior (10.7%), intermediate (5.4%). Nongranulomatous (85.2%) noninfectious (69.3%) frequent types uveitis. The identifiable specific...
The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation angiogenesis. We investigated the involvement of these their processing metalloproteinases ADAM10 ADAM17 pathophysiology proliferative diabetic retinopathy (PDR). Vitreous samples from 32 PDR 24 non-diabetic patients, epiretinal membranes 18 patients with PDR, rat retinas, human retinal Müller glial cells microvascular endothelial (HRMECs) were studied by enzyme-linked immunosorbent...
Purpose: To analyze clinical patterns, causes, and systemic disease associations among patients with uveitis admitted to King Abdulaziz University Hospital.Methods: The authors retrospectively reviewed the medical records of 351 (600 eyes).Results: study subjects consisted 183 (52.1%) males 168 (47.9%) females, a mean age 39.9 ± 14.2 years at presentation. most common anatomic diagnosis was panuveitis (68.6%), followed by posterior (12.7%), anterior intermediate (6.0%). identifiable specific...
The macrophage migration inhibitory factor (MIF)/CD74 signaling pathway is strongly implicated in inflammation and angiogenesis. We investigated the expression of MIF its receptor CD74 proliferative diabetic retinopathy (PDR) to reveal a possible role this pathogenesis PDR. Levels MIF, soluble (s)CD74, intercellular adhesion molecule-1 (sICAM-1) vascular endothelial growth (VEGF) were significantly increased vitreous from patients with PDR compared nondiabetic control samples. detected...