A5045532284- Chemokine receptors and signaling
- Connective Tissue Growth Factor Research
- Glycosylation and Glycoproteins Research
- Pulmonary Hypertension Research and Treatments
- Protease and Inhibitor Mechanisms
- Transplantation: Methods and Outcomes
- Peptidase Inhibition and Analysis
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Retinal Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Lymphoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Respiratory viral infections research
- Viral-associated cancers and disorders
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- Orthopedic Infections and Treatments
Rega Institute for Medical Research
2019-2024
KU Leuven
2018-2024
The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation angiogenesis. We investigated the involvement of these their processing metalloproteinases ADAM10 ADAM17 pathophysiology proliferative diabetic retinopathy (PDR). Vitreous samples from 32 PDR 24 non-diabetic patients, epiretinal membranes 18 patients with PDR, rat retinas, human retinal Müller glial cells microvascular endothelial (HRMECs) were studied by enzyme-linked immunosorbent...
The macrophage migration inhibitory factor (MIF)/CD74 signaling pathway is strongly implicated in inflammation and angiogenesis. We investigated the expression of MIF its receptor CD74 proliferative diabetic retinopathy (PDR) to reveal a possible role this pathogenesis PDR. Levels MIF, soluble (s)CD74, intercellular adhesion molecule-1 (sICAM-1) vascular endothelial growth (VEGF) were significantly increased vitreous from patients with PDR compared nondiabetic control samples. detected...
Purpose: Endogenous tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) has powerful regulatory effects on inflammation and angiogenesis. In this study, we investigated the role TIMP-3 in regulating diabetic retina. Methods: Vitreous samples from patients with proliferative retinopathy (PDR) non-diabetic were subjected to Western blot analysis. Streptozotocin-treated rats used as a preclinical (DR) model. Blood-retinal barrier (BRB) breakdown was assessed fluorescein isothiocyanate...
Growth factors such as vascular endothelial growth factor (VEGF), fibroblast (FGF) and epidermal (EGF) are important angiogenesis-mediating factors. They exert their effects not only through respective receptor tyrosine kinases (RTKs), but they also require molecular pairing with heparan sulfate proteoglycans (HSPGs). Angiogenic signaling pathways commonly targeted in current anti-angiogenic cancer therapies have unfortunately insufficient impact on patient survival. Considering obvious role...
Abstract Background Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis activated T cells and natural killer (NK) via interaction with its G protein-coupled receptor (GPCR), 3 (CXCR3). As consequence posttranslational modifications, human CXCL10 exhibits high degree structural functional heterogeneity. However, the biological effect processing at carboxy (C)-terminus has remained partially elusive. We studied (1–73) , lacking...
Background Connective tissue growth factor (CTGF) is an important mediator in several fibrotic diseases, including lung fibrosis. We investigated CTGF-expression chronic allograft dysfunction (CLAD) and pulmonary graft-versus-host disease (GVHD). Materials Methods CTGF expression was assessed by quantitative real-time polymerase chain reaction (qPCR) immunohistochemistry end-stage CLAD explant (bronchiolitis obliterans syndrome (BOS), n=20; restrictive (RAS), n=20), GHVD (n=9). Unused donor...
Chronic hepatitis C virus (HCV) infection accounts for a large proportion of hepatic fibrosis and carcinoma cases observed worldwide. Mechanisms involved in HCV-induced injury have yet to be fully elucidated. Of particular interest is the capacity HCV regulate inflammatory responses. Here, we reveal modulation cytokine activity by proteins non-structural protein 3 (NS3), glycoprotein E2, core their ability induce chemokine expression various liver bystander cells. Chemokines sustain chronic...
Renal fibrosis accompanies all chronic kidney disorders, ultimately leading to end-stage disease and the need for dialysis or even renal replacement. As such, poses a major threat global health search effective therapeutic strategies prevent treat is highly needed. We evaluated applicability of positively charged human peptide derived from COOH-terminal domain chemokine CXCL9, namely CXCL9(74-103), intervention. Because its high density net positive charges at physiological pH, CXCL9(74-103)...
ABSTRACT Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis activated T cells and natural killer (NK) via interaction with its G protein-coupled receptor (GPCR), 3 (CXCR3). As consequence posttranslational modifications, human CXCL10 exhibits high degree structural functional heterogeneity. However, the biological effect processing at carboxy (C)-terminus has remained partially elusive. The truncated proteoform (1-73) ,...