A5036190162- Malaria Research and Control
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Antibiotic Resistance in Bacteria
- Hemoglobinopathies and Related Disorders
- Invertebrate Immune Response Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Iron Metabolism and Disorders
- Research on Leishmaniasis Studies
- HIV/AIDS drug development and treatment
Burnet Institute
2023-2024
The University of Melbourne
2023
With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), inhibited the ring-stage development of newly invaded merozoites. Here, we select parasites resistant M-833 and identify mutations in START lipid transfer protein (PF3D7_0104200, PfSTART1). Introducing PfSTART1 into wildtype reproduces as well more potent analogues. binding analogues validated using organic solvent-based...
The malaria parasite uses actin-based mechanisms throughout its lifecycle to control a range of biological processes including intracellular trafficking, gene regulation, motility and invasion. In this work we assign functions the Plasmodium falciparum formins 1 2 (FRM1 FRM2) proteins in asexual sexual blood stage development. We show that FRM1 is essential for merozoite invasion FRM2 required efficient cell division. also observed divergent gametocyte Conditional deletion leads delay...
With the resistance increasing to current antimalarial medicines, there is an urgent need discover new drug targets and develop medicines against these targets. We therefore screened Open Global Health Library of Merck KGaA, Darmstadt, Germany, 250 compounds asexual blood stage deadliest malarial parasite Plasmodium falciparum, from which eight inhibitors with low micromolar potency were found. Due its combined potencies growth inhibition red cell invasion, pyridyl-furan compound OGHL250 was...
ABSTRACT With resistance increasing to current antimalarial medicines, there is an urgent need discover new drug targets and develop medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germany 250 compounds asexual blood stage deadliest malarial parasite Plasmodium falciparum, from which eight inhibitors with low micromolar potency were found. Due its combined potencies growth inhibition red cell invasion, pyridyl-furan compound...
Abstract With resistance to most antimalarials increasing, it is imperative that new antimalarial drugs are developed replace or complement front-line artemisinin therapies. We previously identified an aryl acetamide compound, MMV006833 (M-833), inhibited ring development of newly invaded merozoites. Here, we selected parasites resistant M-833 and independent mutations arising in the START lipid transfer protein (PF3D7_0104200, PfSTART1). Introduction PfSTART1 into wildtype reproduced both...