A5058972547- Polymer crystallization and properties
- Neuroscience and Neuropharmacology Research
- biodegradable polymer synthesis and properties
- Biochemical Acid Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Eicosanoids and Hypertension Pharmacology
- Alzheimer's disease research and treatments
- Microplastics and Plastic Pollution
- Molecular Sensors and Ion Detection
Universitat de Barcelona
2022-2024
Institut de Ciències del Mar
2023
Enzymatic degradation of polyethylene terephthlate (PET) by polyester hydrolases is currently subject to intensive research, as it considered a potential eco-friendly recycling method for plastic waste. However, the substrate-binding mode and molecular mechanism enzymatic PET hydrolysis are still under intense investigation, controversial hypotheses have been presented. To help unravel inherent biocatalytic at atomic level, we performed solid-state NMR measurements cutinase from Thermobifida...
With innumerable clinical failures of target-specific drug candidates for multifactorial diseases, such as Alzheimer's disease (AD), which remains inefficiently treated, the advent multitarget discovery has brought a new breath hope. Here, we disclose class 6-chlorotacrine (huprine)-TPPU hybrids dual inhibitors enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), profile to provide cumulative effects against neuroinflammation memory impairment. Computational studies...
A modified lysine residue containing an environment-sensitive moiety was prepared through a straightforward synthesis, and its fluorescent properties were examined. The new sensor, DMN-BocK, can monitor amyloid aggregation processes associated with neurodegenerative diseases such as Alzheimer's or Parkinson's. DMN-BocK offers advantages over classical amyloid-specific dyes like Thioflavins Congo Red because it is (1) available to detect broader range of structures; (2) useful both in vitro...