A5045462576- Nanoparticle-Based Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Microfluidic and Capillary Electrophoresis Applications
- Hemoglobin structure and function
- Neonatal Health and Biochemistry
- Chemotherapy-induced cardiotoxicity and mitigation
- Electrowetting and Microfluidic Technologies
- Electrostatic Discharge in Electronics
- Anesthesia and Neurotoxicity Research
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Mass Spectrometry Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Iron Metabolism and Disorders
- Microfluidic and Bio-sensing Technologies
- Advancements in Semiconductor Devices and Circuit Design
- Integrated Circuits and Semiconductor Failure Analysis
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
The University of Western Australia
2015-2020
Crawley Hospital
2020
Agency for Science, Technology and Research
2004
Institute of Microelectronics
2004
The adsorption of serum proteins on the surface nanoparticles (NPs) delivered into a biological environment has been known to alter NP properties and consequently their targeting efficiency. In this paper, we use random copolymer (p(HEMA-ran-GMA))-based NPs synthesized using 2-hydroxyethyl methacrylate (HEMA) glycidyl (GMA). We show that bind functionalization with antibodies peptides designed facilitate passage across blood–brain barrier (BBB) specific cell types is ineffective. particular,...
The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to non-PEGylated PGMA NPs. Despite reputation PEGylated NPs for stealth functionality, we demonstrate preferential enrichment specific serum proteins varied biological function in when Additionally, suggest that base material polymeric plays a role select hard corona.
Nanoparticle drug delivery applications have predominantly focused on the entrapment and of hydrophobic molecules with poor water solubility. However, benefits can also be obtained from nanoparticle-based hydrophilic therapeutics. This study reports development a p(HEMA-ran-GMA)-based nanoparticle synthesized via spontaneous water-in-oil inverse nanoemulsion to deliver doxorubicin, water-soluble chemotherapeutic. High loading efficiency sustained release doxorubicin Cy5-functionalized...
Transferrin (Tf)-functionalized p(HEMA-ran-GMA) nanoparticles were designed to incorporate and release a water-soluble combination of three ion channel antagonists, namely zonampanel monohydrate (YM872), oxidized adenosine triphosphate (oxATP) lomerizine hydrochloride (LOM) identified as promising therapy for secondary degeneration that follows neurotrauma. Coupled with mean hydrodynamic size 285 nm near-neutral surface charge -5.98 mV, the hydrophilic nature functionalized polymeric was...
Failure mechanisms in plastic packaged optocouplers have been investigated. The high failure rate of the optocouplers, specifically reverse bias leakage current light emitting diodes (LEDs), was found to be moisture-related. Using scanning electron microscopy coupled with energy dispersive X-ray microanalysis, a significant concentration copper detected on surface failed LEDs, possibly migrated from leadframe. By applying infra-red photoemission it that bandgap emission associated path area...
This study demonstrates precise profile control of 3D lateral junction traps in silicon by exploiting a 2D mask layout and isotropic etching. The penetrate through partitions laterally link microfluidic channels. Since the trap constrictions cannot be registered directly planar lithography, they are not trivial to define but critical for capturing cells suspension. A special introduced here when combined with etching can form elliptic circular constrictions. offers three design parameters:...
Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and vivo. In the associated research article [1] we generate multimodal polymeric functionalized with an antibody, that are designed deliver anti-oxidant astrocytes. Here provide additional data demonstrating effects of preparations on indicator oxidative stress immortalized Müller cell line vitro. We use nanoscale secondary ion mass spectroscopy...