A5000461493- Tumors and Oncological Cases
- Bacterial Infections and Vaccines
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Obstructive Sleep Apnea Research
- Down syndrome and intellectual disability research
- Noise Effects and Management
- Fungal Infections and Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
- Hearing, Cochlea, Tinnitus, Genetics
- Streptococcal Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Olfactory and Sensory Function Studies
- Global Education and Multiculturalism
- Polyomavirus and related diseases
Children's Hospital Colorado
2019-2025
University of Colorado Denver
2019-2025
University of Colorado Anschutz Medical Campus
2021-2025
University of Colorado Health
2024
Boston College
2014
Washington University in St. Louis
2004-2006
Saint Louis University
2002-2004
St. Louis Children's Hospital
2004
Washington University Medical Center
2004
University of Iowa
1999
Down syndrome (DS), which arises from trisomy of the whole or part chromosome 21 (Hsa21), is one most common genetic abnormalities in humans. DS manifests as a broad spectrum phenotypic features, including hearing loss due to otitis media with effusion (OME), affecting around 50% children DS. We employed panel mouse models comprising nested series duplications covering regions genome syntenic Hsa21 order define loci involved OME identified major locus on 16, containing only 12 genes, that...
Background: Otitis media (OM) is defined as middle ear (ME) inflammation that usually due to infection. Globally, OM a leading cause of hearing loss and the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, poorer outcomes. However, date, no studies have investigated bacterial profiles children DS OM. Method: We aimed determine if there are differences composition or relative abundance...
Down syndrome (DS), which arises from trisomy of the whole or part chromosome 21 (Hsa21), is one most common genetic abnormalities in humans. DS manifests as a broad spectrum phenotypic features, including hearing loss due to otitis media with effusion (OME), affecting around 50% children DS. We employed panel mouse models comprising nested series duplications covering regions genome syntenic Hsa21 order define loci involved OME identified major locus on 16, containing only 12 genes, that...
Introduction The acoustic trauma patients are exposed to during otologic surgery is unclear, as previous studies have not captured the effects of vibrational noise on inner ear. To fill this knowledge gap, we examined ear directly via intracochlear pressure changes a mastoidectomy and cochleostomy. Methods Inner stimulation was measured using fiber optic sensors inserted into cochlea cadaveric heads trans-canal approach. A tympanomeatal flap elevated, cochleostomies were made scala vestibuli...
Background The aim of this study was to review the presentation and management children admitted for intracranial complications arising from frontal rhinosinusitis. We performed a retrospective case series at two academic tertiary care children's hospitals. Methods This consisted <18 years old who presented with rhinosinusitis between January 1, 1990 December 31, 2002. Relevant literature reviewed assistance Medline. Presentation, type complication, radiographic evaluations, response...
OBJECTIVE: To evaluate sinonasal manifestations of posttransplant lymphoproliferative disorder (PTLD) in the pediatric lung transplant population. STUDY DESIGN AND METHODS: Case series children less than 18 years presenting with PTLD after pulmonary transplantation at St Louis Children's Hospital between Jan 1, 1990 and Dec 31, 2003. RESULTS: Two hundred eighty‐two transplants were performed 246 children. Thirty‐two cases histopathologically confirmed identified 8 (25%) head neck. Sinonasal...
Objectives/Hypothesis To reanalyze the growth trajectory and assess longitudinal changes of children undergoing adenotonsillectomy (AT) versus watchful waiting (WW) enrolled in Childhood Adenotonsillectomy Trial (CHAT) study to determine if an AT increases risk obesity children. Study Design Reanalysis prospective cohort investigation. Methods The analyzed publicly available data from CHAT, including 3 months visit not previously included a prior publication. Statistical comparisons...
Introduction Traditional frontal sinus stents serve only as mechanical devices. It has been proposed that also may drug-delivery systems for the topical application of drugs minimize postoperative scarring. Paclitaxel (Taxol), which recognized antiscarring effects, be incorporated via a polymeric formulation into standard rubber stents. The impact topically applied paclitaxel on morphology nasal mucosa is unknown. Methods An adult sheep model was used this study. A modified T-tube stent...
This study addresses the following research question: How does telementoring urban high school students by English teacher candidates develop candidates' cultural competence and impact mentees' identity development? Mentee-mentor exchanges were analyzed to uncover how mentees used writing identity, mentors' responses demonstrated competence, enhanced development. Data analysis revealed two themes of synergy, where mentor-mentee enabled mutual learning. As mentors respect through exploration,...
Rosai-Dorfman-Destombes disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare form of non-Langerhans cells histiocytosis. It has wide-ranging variability in presentation since first described 1969 but much its characteristics children remain unknown.A retrospective chart review diagnosed RDD at tertiary care children's hospital was conducted from 2000 to 2021.Twelve patients were identified, an average age 7 years (SD 4.3). Males comprised 58% the cohort, and African...