A5103039854- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Lipid Membrane Structure and Behavior
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- ATP Synthase and ATPases Research
Vollum Institute
2024
Oregon Health & Science University
2024
Johns Hopkins University
2019-2024
Johns Hopkins Medicine
2024
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity is associated with cognitive disability multiple sclerosis (MS). Myelin can be restored by regenerating from resident progenitors; however, it not known whether regeneration restores the complex myelination patterns circuits. Here, we performed time lapse vivo two photon imaging somatosensory cortex adult mice to define kinetics specificity after acute oligodendrocyte ablation. These...
ABSTRACT Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes establish this pattern by selecting cohort axons for myelination; however, distribution on distinct neurons and extent internode replacement after demyelination remain to be defined. Here we that myelination patterns seven neuron subtypes somatosensory are influenced both axon diameter neuronal identity. Preference parvalbumin interneurons was preserved between cortical areas with varying density,...
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three regions in a spatiotemporal gradient ventral to dorsal. However, functional importance of this developmental heterogeneity is unknown. Using genetic strategy ablate dorsally derived lineage cells (OLCs), we show here that areas which OLCs normally reside adult central nervous system become populated myelinated by origin. These ectopic...
Oligodendrocytes exert a profound influence on neural circuits by accelerating action potential conduction, altering excitability, and providing metabolic support. As oligodendrogenesis continues in the adult brain is essential for myelin repair, uncovering factors that control their dynamics necessary to understand consequences of adaptive myelination develop new strategies enhance remyelination diseases such as multiple sclerosis. Unfortunately, few methods exist analysis oligodendrocyte...
ABSTRACT Myelin sheaths in the CNS are generated by tips of oligodendrocyte processes, which wrap axons to accelerate action potential conduction, provide metabolic support and control excitability. Here we identify a distinct mode myelination, conserved between zebrafish, mouse human, oligodendrocytes extend myelin along individual linking across nodes Ranvier (NoR). By forming thin extensions that cross NoR, term paranodal bridges, multiple can be connected soma single cytoplasmic process....
ABSTRACT Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity is associated with cognitive disability multiple sclerosis (MS). Myelin can be restored by regenerating from resident progenitors; however, it not known whether regeneration restores the complex myelination patterns circuits. Here we performed time lapse vivo two photon imaging somatosensory cortex adult mice to define kinetics specificity after acute oligodendrocyte...
ABSTRACT Oligodendrocytes exert a profound influence on neural circuits by accelerating axon potential conduction, altering excitability and providing metabolic support. As oligodendrogenesis continues in the adult brain is essential for myelin repair, uncovering factors that control their dynamics necessary to understand consequences of adaptive myelination develop new strategies enhance remyelination diseases such as multiple sclerosis. Unfortunately, few methods exist analysis...
ABSTRACT Axons in the cerebral cortex exhibit diverse patterns of myelination, with some axons devoid myelin, exhibiting discontinuous patches and others continuous myelin that is interrupted only by nodes Ranvier. Oligodendrocytes establish this pattern sorting through a high density potential targets to select small cohort for myelination; however, myelination established on distinct excitatory inhibitory neurons within remain be fully defined little known about extent which these are...