A5101396733- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Retinal and Optic Conditions
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
Aga Khan University Hospital
2025
Aga Khan University
2020-2024
<title>Abstract</title> Mitochondria play a crucial role in cellular functions, including immune responses and their dysfunction is observed SARS-CoV-2-infected cells. Here we investigated mitochondrial DNA (mtDNA) variations COVID-19 severity, focusing on potential impact of variants and/or haplogroups. PCR cases (n = 147) healthy controls (HC; n 40) were recruited, mt-DNA was amplified, sequenced analyzed for haplogroups genetic variations. categorized as Critical severe (CS; 40), Moderate...
SARS-CoV-2 variants of concern (VOC) have been associated with increased viral transmission and disease severity. We investigated the mechanisms pathogenesis caused by using a host blood transcriptome profiling approach. analysed transcriptional signatures COVID-19 patients comparing those infected wildtype (wt), alpha, delta or omicron strains seeking insights into infection in Asymptomatic cases. Comparison profiles Symptomatic cases showed differentially regulated gene (DEGs)...
Abstract Objectives Pakistan has a high infectious disease burden with about 265,000 reported cases of COVID-19. We investigated the genomic diversity SARS-CoV-2 strains and present first data on viruses circulating in country. Methods performed whole-genome sequencing analysis eleven isolated March May. Results Strains from travelers clustered those China, Saudi Arabia, India, USA Australia. Five eight were GH clade Spike glycoprotein D614G, Ns3 gene Q57H, RNA dependent polymerase (RdRp)...
<title>Abstract</title> SARS-CoV-2 variants of concern (VOC) have been associated with increased viral transmission and disease severity. We investigated the mechanisms pathogenesis caused by using a host blood transcriptome profiling approach. analysed transcriptional signatures COVID-19 patients comparing those infected wildtype (wt), alpha, delta or omicron strains seeking insights into infection in Asymptomatic cases. Comparison profiles Symptomatic cases showed differentially regulated...