A5016418065- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
Friedrich-Loeffler-Institut
2022-2025
Abstract ‘Staggering disease’ is a neurological disease entity considered threat to European domestic cats ( Felis catus ) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), relative of rubella virus, recently been shown be associated with encephalitis in broad range mammalian hosts. Here, we report the detection RusV RNA and antigen by metagenomic sequencing, RT-qPCR, in-situ hybridization immunohistochemistry brain tissues 27 out 29 non-suppurative...
ABSTRACT Like other RNA viruses, foot-and-mouth disease virus (FMDV) has a high mutation rate. After the acute phase of infection, about half infected cattle develop persistent FMDV infection that can last for weeks or months. During this phase, continues to replicate, resulting in emergence genomic heterogeneity. We have documented pattern mutations by obtaining consensus-level sequences directly from oropharyngeal fluid (OPF) without prior isolation culture. OPF samples were repeatedly...
Graphical Abstract
The foot-and-mouth disease virus (FMDV) Leader proteinase Lpro inhibits host mRNA translation and blocks the interferon response which promotes viral survival. is not required for replication in vitro but serotype A FMDV lacking has been shown to be attenuated cattle pigs. However, it known, whether leaderless viruses can cause persistent infection vivo after simulated natural phenotype same other serotypes. We have generated a O/FRA/1/2001 variant most of coding region (ΔLb). Cattle were...
ABSTRACT While the virome and immune system of bats rodents have been extensively studied, comprehensive data are lacking for insectivores. Anthropogenic land use outdoor recreational activities may lead to an expansion human-shrew interface with risk zoonotic infections, as reported Borna disease virus 1. We investigated virosphere four white-toothed shrew species from Central Europe, addressing One Health concept spillover prevention. A high diversity viruses was identified, including...
Safe sample transport is of great importance for infectious diseases diagnostics. Various treatments and buffers are used to inactivate pathogens in diagnostic samples. At the same time, adequate preservation, particularly nucleic acids, essential allow an accurate laboratory diagnosis. For viruses with single-stranded RNA genomes positive polarity, such as foot-and-mouth disease virus (FMDV), however, naked full-length viral can itself be infectious. In order assess risk infection from...
Safe sample transport is of great importance for infectious diseases diagnostics. Various treatments and buffers are used to inactivate pathogens in diagnostic samples. At the same time, adequate preservation, particularly nucleic acids, essential allow an accurate laboratory diagnosis. For viruses with single-stranded RNA genomes positive polarity, such as foot-and-mouth disease virus (FMDV), however, naked full-length viral can itself be infectious. In order assess risk infection from...
ABSTRACT ‘Staggering disease’ is a neurological disorder considered threat to European domestic cats ( Felis catus ) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), relative of rubella virus, recently been shown be associated with encephalitis in broad range mammalian hosts. Here, we report the detection RusV RNA and antigen by metagenomic sequencing, RT-qPCR, in-situ hybridization immunohistochemistry brain tissues 28 out 29 non-suppurative...