A5011755569- Soft Robotics and Applications
- Effects of Radiation Exposure
- Ear Surgery and Otitis Media
- Ultrasound and Hyperthermia Applications
- Facial Nerve Paralysis Treatment and Research
- Meningioma and schwannoma management
- Radiation Therapy and Dosimetry
- Hearing Loss and Rehabilitation
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Spinal Fractures and Fixation Techniques
- Stroke Rehabilitation and Recovery
- Cellular Mechanics and Interactions
- Sinusitis and nasal conditions
- Elasticity and Material Modeling
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Robotics and Sensor-Based Localization
- Bone Tissue Engineering Materials
- Reconstructive Facial Surgery Techniques
- Vitamin C and Antioxidants Research
- Collagen: Extraction and Characterization
- Modular Robots and Swarm Intelligence
- Advanced Radiotherapy Techniques
- History of Medical Practice
Montefiore Medical Center
2025
Albert Einstein College of Medicine
2025
University of Bern
2011-2021
University of Mount Union
2020
Textron Systems (United Kingdom)
2015
University Hospital of Bern
2011-2014
GTx (United States)
2014
In-Q-Tel
2014
Purdue University West Lafayette
2009-2012
Medical University of Vienna
2011
Abstract Despite extensive use of type I collagen for research and medical applications, its fibril‐forming or polymerization potential has yet to be fully defined exploited. Here, we describe a formulation that is acid solubilized from porcine skin (PSC), quality controlled based upon potential, well suited as platform polymer preparing three‐dimensional (3D) culture systems injectable/implantable in vivo cellular microenvironments which both relevant biochemical biophysical parameters can...
Surgical robot systems can work beyond the limits of human perception, dexterity and scale making them inherently suitable for use in microsurgical procedures. However, despite extensive research, image-guided robotics applications microsurgery have seen limited introduction into clinical care to date. Among others, challenges are geometric haptic resolution at which surgeon cannot sufficiently control a device outside range faculties. Mechanisms required ascertain redundant on process...
To demonstrate the feasibility of robotic middle ear access in a clinical setting, nine adult patients with severe-to-profound hearing loss indicated for cochlear implantation were included this trial. A keyhole tunnel to tympanic cavity and targeting round window was planned based on preoperatively acquired computed tomography image data robotically drilled level facial recess. Intraoperative imaging performed confirm sufficient distance drilling trajectory relevant anatomy. Robotic...
Conclusion: A robot built specifically for stereotactic cochlear implantation provides equal or better accuracy levels together with a integration into clinical environment, when compared existing approaches based on industrial robots. Objectives: To evaluate the technical of robotic system developed lateral skull base surgery in an experimental set-up reflecting intended application. The invasiveness electrode procedures may be reduced by replacing traditional mastoidectomy small tunnel...
A previously developed image-guided robot system can safely drill a tunnel from the lateral mastoid surface, through facial recess, to middle ear, as viable alternative conventional mastoidectomy for cochlear electrode insertion.Direct access (DCA) provides minimally invasive surface of recess ear insertion. safe and effective drilled narrow requires highly accurate surgical system. Previous attempts have relied on patient-specific templates robotic systems guide drilling tools. In this...
Image-guided microsurgery requires accuracies an order of magnitude higher than today's navigation systems provide. A critical step toward the achievement such low-error requirements is a highly accurate and verified patient-to-image registration. With aim reducing target registration error to level that would facilitate use image-guided robotic on rigid anatomy head, we have developed semiautomatic fiducial detection technique. Automatic force-controlled localization fiducials patient...
A major component of minimally invasive cochlear implantation is atraumatic scala tympani (ST) placement the electrode array. This work reports on a semiautomatic planning paradigm that uses anatomical landmarks and surface models for cochleostomy target insertion trajectory computation. The method was validated in human whole head cadaver model (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:math>ears)....
The application of image-guided systems with or without support by surgical robots relies on the accuracy navigation process, including patient-to-image registration. surgeon must carry out procedure based information provided system, usually being able to verify its correctness beyond visual inspection. Misleading surrogate parameters such as fiducial registration error are often used describe success while a lack methods describing effects errors, those caused tracking calibration, may...
Delivering cochlear implants through a minimally invasive tunnel (1.8 mm in diameter) from the mastoid surface to inner ear is referred as direct access (DCA). Based on cone beam well micro-computed tomography imaging, this vitro study evaluates feasibility and efficacy of manual electrode array insertions via DCA. Free-fitting arrays were inserted 8 temporal bone specimens with previously drilled DCA tunnels. The insertion depth angle, procedural time, alignment scala intracochlear trauma...
Hypothesis: A multielectrode probe in combination with an optimized stimulation protocol could provide sufficient sensitivity and specificity to act as effective safety mechanism for preservation of the facial nerve case unsafe drill distance during image-guided cochlear implantation. Background: minimally invasive implantation is enabled by robotic-assisted drilling access tunnel middle ear cavity. The approach requires pass at distances below 1 mm from thus mechanisms protecting this...
The delicate anatomy of the ear require surgeons to use great care when operating on its internal structures. One example for such an intervention is stapedectomy, where a small crook shaped piston placed in oval window cochlea and connected incus through crimping thus bypassing diseased stapes. Performing crimp process with correct force necessary since loose crimps poorly transmit sound whereas tight will eventually result necrosis incus. Clinically, demand high reproducibly conduct...
Reported studies pertaining to needle guidance suggest that tissue impedance available from neuromonitoring systems can be used discriminate nerve proximity. In this pilot study, the existence of a relationship between intraoperative electrical and density, estimated computer tomography (CT) images, is evaluated in mastoid bone vivo sheep. five subjects, nine trajectories were drilled using an image-guided surgical robot. Per trajectory, measurement points near facial accessed was measured...
The aim of direct cochlear access (DCA) is to replace the standard mastoidectomy with a small diameter tunnel from lateral bone surface cochlea for electrode array insertion. In contrast previous attempts, approach described in this work not only achieves an unprecedented high accuracy, but also contains several safety sub-systems. This paper provides brief description system components, and summarizes accuracy results using cadaver model over past two years.
Hypothesis To evaluate the feasibility and results of insertion two types electrode arrays in a robotically assisted surgical approach. Background Recent publications demonstrated that robot-assisted surgery allows implantation free-fitting through cochleostomy drilled via narrow bony tunnel (DCA). We investigated if from different manufacturers could be used with this Methods Cone-beam CT imaging was performed on fivecadaveric heads after placement fiducial screws. Relevant anatomical...
Facial nerve monitoring can be used synchronous with a high-precision robotic tool as functional warning to prevent of collision the drill bit facial during direct cochlear access (DCA).Minimally invasive (DCA) aims eliminate need for mastoidectomy by drilling small tunnel through recess cochlea aid stereotactic guidance. Because procedure is performed in blind manner, structures such are at risk. Neuromonitoring commonly help surgeons identify (FN) routine surgical procedures mastoid....
Robotic assistance in the context of lateral skull base surgery, particularly during cochlear implantation procedures, has been subject considerable research over last decade. The use robotics these procedures potential to provide significant benefits patient by reducing invasiveness when gaining access cochlea, as well intracochlear trauma performing a cochleostomy. Presented herein is preliminary work on combination two robotic systems for and procedures. A system minimally invasive inner...
ABSTRACT To demonstrate the feasibility of robotic middle ear access in a clinical setting, nine adult patients with severe-to-profound hearing loss indicated for cochlear implantation were included this trial. A keyhole tunnel to tympanic cavity and targeting round window was planned based on preoperatively acquired computed tomography image data robotically drilled level facial recess. Intraoperative imaging performed confirm sufficient distance drilling trajectory relevant anatomy....
Abstract Background and purpose The normal tissue sparing afforded by FLASH radiotherapy (RT) is being intensely investigated for potential clinical translation. Here, we studied the effects of proton RT (F-PRT) in reirradiation setting, with or without hypofractionation. Chronic toxicities three murine models toxicity including intestine, skin, bone were investigated. Materials methods In studies single-dose irradiation was performed 12 Gy Standard (S-PRT), followed a second dose F-PRT...
Caffeine is a widely consumed stimulant on the beverage market. It known to affect autonomic nervous system (ANS), influencing balance of parasympathetic versus sympathetic drive. This can be measured by heart rate variability (HRV) – fine scale changes in normal sinus rhythm. However, there has been little research done regarding influence caffeinated drinks have HRV active university students. The purpose this observational study examine relationship between habitual caffeine intake and...