A5033006141- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Plant-based Medicinal Research
- Metal-Catalyzed Oxygenation Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Anesthesia and Pain Management
- Magnetism in coordination complexes
- Epilepsy research and treatment
Poznan University of Medical Sciences
2017-2023
University of Florida
2020
Columbus Oncology and Hematology Associates
2020
Dexmedetomidine (DEX) is a fairly new alfa2-agonist which has been increasingly used in recent years for analgosedation, mostly because it offers unique ability of providing both moderate level sedation and analgesia without respiratory depression. Despite many papers published, there are still only few concerning the PK drug given as long-term infusion ICU patients. The aim this work was to characterize population pharmacokinetics dexmedetomidine investigate potential benefits...
The cyclotetramerization reaction following the Linstead approach led to novel symmetrical magnesium(II) aminoporphyrazines with methyl(6-bromo-3-pyridylmethyl) and methyl(4-bromobenzyl) substituents. These products were applied in demetallation procedure trifluoroacetic acid dark, which resulted free-base porphyrazine derivatives. Then these macrocycles remetallated iron(II) bromide DMF give desired iron(III) macrocycles. Simultaneously, of maleonitrile derivatives manganese(II) chloride...
Abstract Dexmedetomidine is a hepatically eliminated drug with sedative, anxiolytic, sympatholytic, and analgesic properties that has been increasingly used for various indications in the form of short or continuous intravenous infusion. This study aimed to propose population pharmacokinetic (PK) model dexmedetomidine heterogeneous group intensive care unit patients, incorporating 29 covariates potentially linked PK. Data were collected from 70 patients aged between 0.25 88 years treated...
Probability of target attainment (PTA) curves are commonly used to support dose recommendations antibiotics for different patient groups. In this study we propose PTA analysis optimize sugammadex dosing in children. This involved data from an observational cohort 30 American Society Anesthesiologists (ASA) Physical Status I and II children undergoing surgery requiring muscle relaxation. All patients received 0.6 mg/kg rocuronium, with administered at the end three doses (0.5, 1.0, 2.0 mg/kg)...
Aim. This study aimed to evaluate the pharmacodynamics of dexmedetomidine in elderly cardiac patients.Material and Methods. Twelve patients 60 years or older need for analgesia after surgery as a result critical health conditions were included into our study. Dexmedetomidine was administered intravenously continuous infusion without initial dose. At beginning started at rate 0.7 µg/kg/h then it continued range 0.17–1.39 according desired level sedation. Information about heart rate,...
One of the problems associated with a patient's stay in hospital and procedures they undergo is delirium, occurrence which numerous complications, longer ward, higher risk death increased healthcare costs. Scientists are continuing to search for effective methods minimise its occurrence, as well develop therapeutic procedures. such area research identification delirium biomarkers, would allow further PK/PD (pharmacokinetic/pharmacodynamic) modelling. This article focuses on emergence occurs...
Background. Dexmedetomidine (DEX) is a widely used sedative agent for treating post-surgery patients. It also acts on hemodynamic parameters like heart rate or cardiac output. This study aimed to develop pharmacokinetic-pharmacodynamic (PK/PD) model of DEX using bispectral index (BIS) and output (CO) as response. Methodology results. 21 mechanically ventilated elderly patients undergoing abdominal aortic surgery were enrolled in the study. was given maintain moderate deep sedation. Genotypes...