A5073723486- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Quinazolinone synthesis and applications
- Cyclopropane Reaction Mechanisms
- Analytical Chemistry and Chromatography
- Synthetic Organic Chemistry Methods
- Protein Kinase Regulation and GTPase Signaling
- Synthesis and Catalytic Reactions
- Chemical Reaction Mechanisms
- Advanced Photocatalysis Techniques
- Enzyme function and inhibition
- Plant-based Medicinal Research
- Synthesis of Indole Derivatives
- Genetics and Neurodevelopmental Disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Porphyrin and Phthalocyanine Chemistry
- Synthesis of Tetrazole Derivatives
- Multicomponent Synthesis of Heterocycles
- Injection Molding Process and Properties
Heriot-Watt University
2020-2023
Novartis (United States)
2023
Novartis (United Kingdom)
2011-2020
MSD (UK) Limited (United Kingdom)
2003-2006
Merck & Co., Inc., Rahway, NJ, USA (United States)
1996-1999
Abstract Commercial polystyrene Merrifield-type resins have been post-synthetically functionalised with BODIPY photosensitisers via a novel aryl ester linking strategy in continuous-flow. A unique synthetic advantage of modifying heterogeneous materials flow was identified. The homogeneous analogues the polymer-supported BODIPYs were synthesised and used as reference to assess photophysical properties altered by polymer-support linker. applied visible-light photosensitisation singlet oxygen...
Recent advancements in in-line extraction and purification technology have enabled complex multistep synthesis continuous flow reactor systems. However, for the large scope of chemical reactions that yield mixtures products or residual starting materials, off-line is still required to isolate desired compound. We present integration a commercial automated flash chromatography system with isolation product(s). A proof-of-principle study was performed validate test durability column...
Abstract Optimisation, scope and mechanism of the platinum‐catalysed addition indoles to indolylallenes is reported here give 2,3′‐BIMs with a novel core structure very relevant for pharmaceutical industry. The reaction modulated by electronic properties substituents on both indoles, favoured when electron donating groups are present. Although simple at first, complex has been uncovered that explains different behaviour these systems platinum compared other metals (e.g. gold). Detailed...
We report a α-metalation-substitution of readily deprotected 5-alkyltetrazoles under batch and continuous flow conditions. In flow, thermal imaging enabled identification an unsafe exotherm optimisation productivity rate 141 g h −1 .
1,2,6-Thiadiazines treated with visible light and 3O2 under ambient conditions are converted into difficult-to-access 1,2,5-thiadiazole 1-oxides (35 examples, yields of 39-100%). Experimental theoretical studies reveal that 1,2,6-thiadiazines act as triplet photosensitizers produce 1O2 then undergo a chemoselective [3 + 2] cycloaddition to give an endoperoxide ring contracts selective carbon atom excision complete economy. The reaction was optimized both batch continuous-flow is also...
Reductive cyclisation of aryl 2-nitroaryl sulphides by triethyl phosphite provides a new synthesis phenothiazines (yields ca. 50–85%) which is superior to that involving the thermal decomposition 2-azidoaryl 30%). Both reactions proceed via novel molecular rearrangement whereby, for example, 4-chlorophenyl 2-nitrophenyl sulphide gives 3-chlorophenothiazine, whereas 4-chloro-2-nitrophenyl phenyl 2-chlorophenothiazine. [4-2H]phenyl similarly [3-2H]phenothiazine, as shown comparison e.s.r....
We have developed a chiral route toward the synthesis of muscarinic M4 agonists that was enabled by biocatalytic key spirocyclic diamine building blocks 10 and 12. Using these bifunctional compounds we were able to optimize synthetic sequence collection advanced intermediates for further elaboration. These then used as starting points early medicinal chemistry identification selective M1/M4 agonists.
Abstract A novel, robust, and scalable synthesis of the title compound (VII) is presented.