A5017300854- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Chemokine receptors and signaling
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Radiopharmaceutical Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Porphyrin and Phthalocyanine Chemistry
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactivity of Heterocycles
- Research on Leishmaniasis Studies
Southwestern Oklahoma State University
2014-2024
Weatherford (United States)
2014-2024
Weatherford (Norway)
2015-2020
University of Oklahoma Health Sciences Center
2015
KU Leuven
2006-2009
Rega Institute for Medical Research
2006-2009
University of Hull
2006-2009
McPherson College
2002-2009
University of Edinburgh
2006
University of Kansas
1998-2003
The high-spin dichloro Mn2+ and Fe2+ complexes of 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (1) 4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane (2) provide durable new compounds these elements for important fundamental studies applications. are especially noteable their exceptional kinetic stabilities redox activity. X-ray crystal structures all four demonstrate that the ligands enforce a distorted octahedral geometry on metals with two cis sites occupied by labile...
A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding acetate via a bidentate chelation that can be related the proposed interaction with aspartate on protein surface. complex is highly active against HIV infection vitro.
A new copper(II) containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties the protein in comparison drug AMD3100 (Plerixafor, Mozobil). The interaction of metallodrug has been optimized by using ultrarigid chelator units that offer an equatorial site for coordination amino acid side chains protein. Binding competition assays with anti-CXCR4 antibodies show compound stays bound longer and it anti-HIV potency vitro (EC50 = 4.3 nM). X-ray...
Background The stromal cell derived factor (SDF)-1/chemokine receptor (CXCR)-4 signaling pathway plays a key role in lung cancer metastasis and is molecular target for therapy. In the present study we investigated whether interleukin (IL)-24 can inhibit SDF-1/CXCR4 axis suppress migration invasion vitro. Further, efficacy of IL-24 combination with CXCR4 antagonists was investigated. Methods Human H1299, A549, H460 HCC827 lines were used study. H1299 line stably transfected...
A family of Mn3+ and Fe3+ complexes 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (1) 4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane (2) has been prepared by the chemical oxidation divalent manganese iron analogues. The ligands are ethylene cross-bridged tetraazamacrocycles derived from cylam cyclen, respectively. synthesis characterization these complexes, including X-ray crystal structure determinations, described. structural evidence demonstrates that tetradentate...
Available data from different laboratories have confirmed that both Ca(2+) and Cl(-) are crucial for water oxidation in Photosystem II. However, their roles still elusive. Using a manganese(II) complex having cross-bridged cyclen ligand as model, the influence of on oxidative reactivity its corresponding manganese(IV) analogue were investigated. It has been found adding can significantly improve oxygenation efficiency sulfide further accelerate sulfoxide to sulfone. Similar improvements also...
The challenge to metal ion binding that is represented by the proton-sponge nature of two-carbon cross-bridged tetraazamacrocycles has been overcome and a general method developed for synthesis their transiton, other, complexes; these ultra-rigid ligands form complexes having remarkable kinetic stabilities.
The first 2-pyridylmethyl pendant-armed ethylene cross-bridged cyclam ligand has been synthesized and successfully complexed to Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+ cations. X-ray crystal structures were obtained for all six complexes demonstrate pentadentate binding of the with requisite cis-V configuration ring in cases, leaving a potential labile site cis pyridine donor interaction complex oxidants and/or substrates. electronic properties evaluated using solid-state magnetic moment...
The chemokine receptor CXCR4 is implicated in multiple diseases including inflammatory disorders, cancer growth and metastasis, HIV/AIDS. targeting has been evaluated treating metastasis therapy resistance. Cyclam derivatives, most notably AMD3100 (Plerixafor™), are a common motif small molecule antagonists. However, not shown to be effective treatment as an individual agent. Configurational restriction transition metal complex formation increases binding affinity residence time. In the...
The parallel syntheses of two new cross-bridged tetraazamacrocyclic complexes whose ligands are derived from 1,4,8,11-tetraazacyclotetradecane (cyclam = 14N4) and rac-1,4,8,11-tetraaza-5,5,7,12,12,14-hexamethylcyclotetradecane (tetB 14N4Me(6)) have been characterized through the crystal structure determination every stepwise intermediate ligand in multistep syntheses. These structures show that although final skeletons nearly identical, immediate precursors differ greatly because six...
Tetraazamacrocyclic complexes of transition metals provide useful units for incorporating multiple coordination interactions into a single protein binding molecule. They can be designed with available sites via donor atom-containing amino acid side chains or labile ligands, such as H(2)O, allowing facile exchange. Three configurationally restricted nickel(II) cyclam either one two macrocyclic rings were synthesised and their ability to abrogate the CXCR4 chemokine receptor signalling process...
Expression of the chemokine receptor C-X-C motif 4 (CXCR4) plays an important role in cancer metastasis, autoimmune diseases, and during stem cell–based repair processes after stroke myocardial infarction. Previously reported PET imaging agents targeting CXCR4 suffer from either high nonspecific uptake or bind only to human form receptor. The objective this study was develop a high-stability <sup>64</sup>Cu-labeled small-molecule agent for both murine receptors. <b>Methods:</b> Synthesis,...
ABSTRACT Praziquantel (PZQ) is the only drug available for treatment of schistosomiasis, and since its large-scale use might be associated with onset resistance, new antischistosomal drugs should developed. A series 26 synthetic tetraazamacrocyclic derivatives their metal complexes were synthesized, characterized, screened activity by application a phased screening program. The compounds first against newly transformed schistosomula (NTS) harvested Schistosoma mansoni cercariae, then adult...
Macrocyclic ligands have been explored extensively as scaffolds for transition metal catalysts oxygen and hydrogen atom transfer reactions. C–C reactions facilitated using earth abundant metals bound to macrocyclic not well-understood but could be a green alternative replacing the current expensive toxic precious systems most commonly used these processes. Therefore, yields from direct Suzuki–Miyaura coupling of phenylboronic acid pyrrole produce 2-phenylpyrrole by eight high-spin iron...
Abstract The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development metastasis. Previous studies have demonstrated that configurationally restricted bis‐tetraazamacrocyclic metal complexes are high‐affinity antagonists. Here, we present the synthesis Cu 2+ Zn acetate six cross‐bridged tetraazamacrocycles to mimic their coordination interaction with aspartate side chains known bind them CXCR4. X‐ray crystal structures for three new two...
The preparation and crystal structures of (4,11-dibenzyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane-κ4N)copper(I) hexa-fluorophosphate, [Cu(C26H38N4)]PF6, acetonitrile(4,11-dibenzyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane-κ4N)-copper(II) bis(hexafluorophosphate), [Cu(C2H3N)(C26H38-N4)](PF6)2, are described. CuI ion is tetracoordinated in a very distorted tetrahedron, while the CuII analogue pentacoordinated square pyramid.