A5000593197- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Appendicitis Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Inflammatory Bowel Disease
- Enhanced Recovery After Surgery
- Diverticular Disease and Complications
- Metal complexes synthesis and properties
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Global Health and Surgery
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- Medical Device Sterilization and Disinfection
- Ureteral procedures and complications
- Genetic factors in colorectal cancer
- Surgical site infection prevention
Queen Elizabeth University Hospital
2017-2025
NHS Greater Glasgow and Clyde
2015-2025
Royal Alexandra Hospital
2024
University of Glasgow
2009-2022
University Hospital Crosshouse
2010-2017
Oxford University Hospitals NHS Trust
2015-2017
Queen Elizabeth Hospital
2016
NHS Ayrshire and Arran
2016
University of Oxford
2015
Western Infirmary
2015
A new copper(II) containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties the protein in comparison drug AMD3100 (Plerixafor, Mozobil). The interaction of metallodrug has been optimized by using ultrarigid chelator units that offer an equatorial site for coordination amino acid side chains protein. Binding competition assays with anti-CXCR4 antibodies show compound stays bound longer and it anti-HIV potency vitro (EC50 = 4.3 nM). X-ray...
Abstract Background Reorganization of colorectal cancer services has led to surgery being increasingly, but not exclusively, delivered by specialist surgeons. Outcomes from have improved, the exact determinants remain unclear. This study explored outcome after over time. Methods Postoperative mortality (within 30 days surgery) and 5-year relative survival rates for patients in West Scotland undergoing between 1991 1994 were compared with those having 2001 2004. Results The 1823 who had...
Abstract Introduction There is growing evidence that the use of robotic-assisted surgery (RAS) in colorectal cancer resections associated with improved short-term outcomes when compared to laparoscopic (LS) or open (OS), possibly through a reduced systemic inflammatory response (SIR). Serum C-reactive protein (CRP) sensitive SIR biomarker and its utility early identification post-operative complications has been validated variety surgical procedures. remains paucity studies characterising...
Yeung, Trevor M. MBBChir, MA, MRCS, DPhil; Volpi, Davide PhD; Tullis, Iain D. C. Nicholson, Gary A. MD; Buchs, Nicolas Cunningham, Chris MD, RCSEd; Guy, Richard FRCS; Lindsey, Ian MBBS, FRACS; George, Bruce MS, Jones, Oliver DM, Mun Wang, Lai MB, BCh, MRCP, FRCPath; Hompes, Roel Vojnovic, Borivoj Hamdy, Freddie FRCSEd (Urol), FRCS, FMedSci; Mortensen, Neil J. FRCS (Eng), Hon FRCPS (Glas), (Ed) Author Information
The new approach of transanal total mesorectal excision is technically challenging and demands a stable field dissection with optimal view anatomical landmarks. We aimed to describe demonstrate modification both the insufflation carbon dioxide smoke evacuation, in order optimize dissection.The comparison standard an AirSeal platform demonstrates clear difference. This shown accompanying video-recordings.A more pneumorectum better evacuation as well convenient precise were achieved...
Obesity (BMI > 30 kg/m2) is rapidly increasing worldwide with 26% of the UK population being obese and 38% overweight. intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patients have a higher degree perioperative systemic inflammatory response (SIR) an increased risk complications. The aim this current study was investigate whether robotic-assisted surgery mitigates effects obesity in left sided CRC resections on SIR clinical outcomes. All...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopper(II) complexes derived from 2,6-diacetylpyridine dioximeG. A. Nicholson, C. R. Lazarus, and B. J. McCormickCite this: Inorg. Chem. 1980, 19, 1, 192–195Publication Date (Print):January 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ic50203a039https://doi.org/10.1021/ic50203a039research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations35LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of the dihydrate a coupled copper(II) dimer derived from 2,6-diacetylpyridine dioximeGary A. Nicholson, Jeffrey L. Petersen, B. Jack McCormickCite this: Inorg. Chem. 1980, 19, 1, 195–200Publication Date (Print):January 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ic50203a040https://doi.org/10.1021/ic50203a040research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of the molecular structures five-coordinate copper(II) and zinc(II) complexes 2,6-diacetylpyridine dioximeGary A. Nicholson, Jeffrey L. Petersen, B. Jack McCormickCite this: Inorg. Chem. 1982, 21, 9, 3274–3280Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ic00139a005https://doi.org/10.1021/ic00139a005research-articleACS...
Low anterior resection (LAR) can present a formidable surgical challenge, particularly for tumours located in the distal third of rectum. Transanal total mesorectal excision (taTME) aims to overcome some these difficulties. We report our initial experience with this technique.From June 2013 September 2014, 20 selected patients underwent transanal rectal various malignant and benign low pathologies. All cancer were discussed at multidisciplinary team meeting. Data entered into prospective...
Meta-analyses have indicated that preoperative mechanical bowel preparation (MBP) confers no clear benefit and may indeed be harmful for patients with colorectal cancer. The effects of on longer-term outcomes not been reported. aim was to compare long-term survival surgical complications in who did or receive MBP before surgery colonic cancer.This a retrospective cohort study all undergoing potentially curative cancer after routine hospital admission the West Scotland between January 2000...
Abstract Background Evidence-based interventions may reduce mortality in surgical patients. This study documented the prevalence of sepsis, adherence to guidelines its management, and timing source control general patients presenting as an emergency. Methods Patients aged 16 years or more with emergency surgery problems were identified over a 7-day period then screened for sepsis compliance (using Sepsis Six standards, devised severe sepsis) (whether radiological surgical). Exploratory...
Abstract Objectives Secondary care Trusts have traditionally been providers of flexible sigmoidoscopy services in the United Kingdom. The aim this study was to establish a Nurse‐led clinic that would provide patient orientated service primary setting. Patients and methods A protocol driven established first thousand patients who underwent at community were prospectively studied. Results nurse endoscopist performed 1002 procedures on 1000 patients. Median time from referral 35 days (Range...
A 27-year-old female heroin addict presented with a peritonitic and distended abdomen. Her medical history included depression 3-year of abuse attendant constipation. CT scan showed free intraperitoneal gas, massive faecal distension the rectum sigmoid colon likely bowel necrosis. She underwent an emergency Hartmann's procedure for perforation colon. Pathology identified two areas stercoral ulceration, one them being area perforation. Postoperatively, patient developed deep vein thrombosis...