A5074884532- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Psychiatric care and mental health services
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Mental Health and Patient Involvement
- Psychosomatic Disorders and Their Treatments
- Educational and Psychological Assessments
- Adolescent and Pediatric Healthcare
- Family Caregiving in Mental Illness
- Disaster Response and Management
- Posttraumatic Stress Disorder Research
- Migration, Health and Trauma
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Digital Mental Health Interventions
- Diet and metabolism studies
- Family and Disability Support Research
- Psychotherapy Techniques and Applications
- Geriatric Care and Nursing Homes
- Autism Spectrum Disorder Research
Manchester Metropolitan University
2019-2025
Pennine Care NHS Foundation Trust
2019-2025
Royal College of Psychiatrists
2021-2024
University of Manchester
2010-2023
Greater Manchester Mental Health NHS Foundation Trust
2012-2021
University of Liverpool
2014-2021
Manchester Academic Health Science Centre
2017-2021
Mental Health Foundation
2010-2020
National Health Service
2019
Queen Elizabeth University Hospital
2017
Advances in the ability to identify people at high risk of developing psychosis have generated interest possibility preventing psychosis.To evaluate efficacy cognitive therapy for prevention transition psychosis.A randomised controlled trial compared with treatment as usual 58 patients ultra-high a first episode psychosis. Therapy was provided over 6 months, and all were monitored on monthly basis 12 months.Logistic regression demonstrated that significantly reduced likelihood making...
<b>Objective</b> To determine whether cognitive therapy is effective in preventing the worsening of emerging psychotic symptoms experienced by help seeking young people deemed to be at risk for serious conditions such as schizophrenia. <b>Design</b> Multisite single blind randomised controlled trial. <b>Setting</b> Diverse services five UK sites. <b>Participants</b> 288 participants aged 14-35 years (mean 20.74, SD 4.34 years) high psychosis: 144 were assigned plus monitoring mental state...
There have been recent advances in the ability to identify people at high risk of developing psychosis. This has led interest possibility preventing development A randomized controlled trial compared cognitive therapy (CT) over 6 months with monthly monitoring 58 patients meeting criteria for ultrahigh a first episode Participants were followed up 3-year period. Logistic regression demonstrated that CT significantly reduced likelihood being prescribed antipsychotic medication period, but it...
Abstract Aim Exercise can improve psychiatric symptoms, neurocognitive functioning and physical health in schizophrenia. However, the effects early psychosis have not been explored. This study aimed to assess feasibility of an exercise intervention for determine if it was associated with changes mental health. Methods Thirty‐one patients first‐episode (FEP) were recruited from services a 10‐week intervention. The group received individualized training programmes, aiming achieve ≥90 min...
Background Obesity is a major challenge for people with schizophrenia. Aims We assessed whether STEPWISE, theory-based, group structured lifestyle education programme could support weight reduction in Method In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations England. Participants were randomly allocated to the STEPWISE intervention treatment as...
Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30-40% patients have an insufficient response, and others are unable to tolerate it. Evidence any augmentation strategies scarce. We aimed determine whether cognitive behavioural therapy (CBT) effective clozapine-resistant schizophrenia.We did a pragmatic, parallel group, assessor-blinded, randomised controlled trial in community-based inpatient mental health services five sites UK. Patients with...
Early warning signs monitoring by service users with schizophrenia has shown promise in preventing relapse but the quality of evidence is low. We aimed to establish feasibility undertaking a definitive randomised controlled trial determine effectiveness blended digital intervention for prevention schizophrenia.This multicentre, feasibility, cluster compare Monitoring Prevent psychosis and prOmote Well-being, Engagement, Recovery (EMPOWER) treatment as usual community mental health services...
Background There is interest in the possibility of indicated prevention psychosis. a strong case for using psychological approaches to prevent transition psychosis high-risk patients. Aims To identify individuals at high risk psychosis, and characteristics relevant development this group. Method The design randomised controlled trial cognitive therapy people (meeting operational criteria brief or attenuated psychotic symptoms, first-degree family history with functional decline) outlined....
Background Decline in social functioning occurs individuals who later develop psychosis. Aims To investigate whether baseline differences disability are present those do and not make a transition to psychosis group clinically at high risk is factor for transition. Method Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking risk. Disability was assessed the Assessment Schedule of World Health Organization (WHODAS–II). Results At baseline,...
Dragt S, Nieman DH, Schultze‐Lutter F, van der Meer Becker H, de Haan L, Dingemans PM, Birchwood M, Patterson P, Salokangas RKR, Heinimaa Heinz A, Juckel G, Graf von Reventlow French Stevens Ruhrmann Klosterkötter J, Linszen on behalf of the EPOS group. Cannabis use and age at onset symptoms in subjects clinical high risk for psychosis. Objective: Numerous studies have found a robust association between cannabis Nevertheless, relationship early (or, retrospect, prodromal) psychosis remains...
After 4 years of debate, a decision has been made. The attenuated psychosis syndrome (APS) will not be coded diagnosis in the Diagnostic and Statistical Manual Mental Disorders (DSM-5). Formerly known as risk syndrome, proposed was based on criteria developed mid-1990s that were informed by comprehensive review retrospective studies prodromal phase nonaffective psychosis.
Provision of early intervention services has increased the rate social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems functioning. We aimed to assess efficacy augmented therapy psychosis. The primary hypothesis was that plus would lead improvements recovery.We did this single-blind, phase 2, randomised controlled trial (SUPEREDEN3) at four specialist UK. included participants who were aged 16-35 years, had...
Previous qualitative studies have found that exercise may facilitate symptomatic and functional recovery in people with long-term schizophrenia. This study examined the perceived effects of as experienced by early stages psychosis, explored which aspects an intervention facilitated or hindered their engagement. Nineteen semi-structured interviews were conducted service users who had participated a 10-week intervention. Interviews discussed people's incentives barriers to exercise, short-...
Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance treatment mostly extrapolated from trials adult populations. The UK National Institute Health and Care Excellence has recommended evaluation clinical cost-effectiveness antipsychotic drugs versus psychological intervention (cognitive behavioural therapy [CBT] family intervention) combination these psychosis. aim this study was to establish feasibility a randomised controlled trial monotherapy,...
Serious problems identified after the 2005 London bombings still remain, argue Kate Allsopp and colleagues Mental health responses for people caught up in terror attacks are often inadequate. Internationally, existing services repeatedly fail to identify those with short long term needs, resulting an increased prevalence of post-traumatic stress disorder, depression, anxiety disorders compared general population.1 Health should plan longer psychosocial care mental treatment substantial...