A5014403173- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Monoclonal and Polyclonal Antibodies Research
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Renal Transplantation Outcomes and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Colorectal Cancer Screening and Detection
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- COVID-19 diagnosis using AI
- Gastrointestinal disorders and treatments
- Hernia repair and management
- Inflammatory Bowel Disease
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Abdominal Surgery and Complications
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Surgical Simulation and Training
- Microscopic Colitis
- Healthcare cost, quality, practices
- Anatomy and Medical Technology
Albert Einstein College of Medicine
2024
University of Birmingham
2023
Queen Elizabeth Hospital Birmingham
2020-2021
NIHR Surgical Reconstruction and Microbiology Research Centre
2016-2021
Sindh Institute of Urology and Transplantation
2020
Churchill Hospital
2012-2015
Oxford University Hospitals NHS Trust
2015
University of Oxford
2008-2014
John Radcliffe Hospital
2008-2014
MRC Weatherall Institute of Molecular Medicine
2008-2012
Abstract Aim Our aim was to determine the frequency and economic impact of anastomotic leakage (AL) at local national levels in E ngland. Method All patients who underwent AR Oxford between 2007 2009 were evaluated for AL . H ospital pisode S tatistics ( HES ) data used reoperation rates after elective n = 23 388) ngland 2000 2008. Hospital episode remuneration costs calculated by commissioning department compared with D epartment ealth DH reference index costs. Results The following...
We have developed an automated, highly sensitive and specific method for identifying enumerating circulating tumour cells (CTCs) in the blood. Blood samples from 10 prostate, 25 colorectal 4 ovarian cancer patients were analysed. Eleven healthy donors seven men with elevated serum prostate-specific antigen (PSA) levels but no evidence of malignancy served as controls. Spiking experiments cell lines performed to estimate recovery yield. Isolation was either by density gradient centrifugation...
Abstract Aim Transanal endoscopic microsurgery (TEM) for early rectal cancer (ERC) gives results similar to major surgery in selected cases. Endorectal ultrasound (ERUS) is an important part of the preoperative selection process. This study reports its accuracy and impact patients entered on UK TEM database. Method The database comprises prospectively collected data 494 patients. set was used determine prevalence ERUS staging by comparing T‐stage with definitive pathological following TEM....
The use of biological therapy (biologicals) is established in the treatment Crohn's disease. This study aimed to determine whether preoperative with biologicals associated an increased rate complications following surgery for disease intestinal anastomosis.All patients receiving and undergoing abdominal anastomosis or strictureplasty were identified at six tertiary referral centres. Demographic data, preoperative, operative postoperative details registered. Patients who treated within 2...
A significant proportion of colorectal cancer (CRC) patients are resistant to anti-ERBB1 [avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, receptor for EGF] monoclonal antibodies (Mabs). We evaluated both immune and nonimmune effects cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 pertuzumab lapatinib (dual ERBB1 ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel 64 CRC cell lines find response predictive tumor characteristics. There was correlation...
Transanal endoscopic microsurgery (TEM) enables organ preservation after rectal tumour surgery. Its application is being expanded using adjuvant and neoadjuvant treatments. Our objective was to evaluate the changes over time in anorectal function, urinary symptoms quality of life (QoL) patients who had TEM surgery for a tumour.Between September 2009 October 2012, consecutive series 102 underwent at single institution. Patients were asked fill out standardized questionnaires baseline then 6,...
The new approach of transanal total mesorectal excision is technically challenging and demands a stable field dissection with optimal view anatomical landmarks. We aimed to describe demonstrate modification both the insufflation carbon dioxide smoke evacuation, in order optimize dissection.The comparison standard an AirSeal platform demonstrates clear difference. This shown accompanying video-recordings.A more pneumorectum better evacuation as well convenient precise were achieved...
Indexing endoscopic surgical videos is vital in data science, forming the basis for systematic retrospective analysis and clinical performance evaluation. Despite its significance, current video analytics rely on manual indexing, a time-consuming process. Advances computer vision, particularly deep learning, offer automation potential, yet progress limited by lack of publicly available, densely annotated datasets. To address this, we present TEMSET-24K, an open-source dataset comprising...
Drugs that inhibit insulin-like growth factor 1 (IGFI) receptor IGFIR were encouraging in early trials, but predictive biomarkers lacking and the drugs provided insufficient benefit unselected patients. In this study, we used genetic screening downstream validation to identify WNT pathway element DVL3 as a mediator of resistance inhibition. Sensitivity inhibition was enhanced specifically vitro vivo by or pharmacologic blockade DVL3. breast prostate cancer cells, sensitization tracked with...
The distribution of carcinoembryonic antigen (CEA) in colorectal cancer (CRC) differs from that normal tissue, being found on all borders the cell membrane and hence enabling access to intravenous antibody, making CEA a good target for antibody-based therapy. distinctive anti-CEA PR1A3, binds only membrane-bound CEA. Humanised PR1A3 (hPR1A3) was assessed both vitro cytotoxicity binding assays with lines expressing varying levels Human peripheral blood mononuclear cells (PBMCs) purified...
The effect of glycoengineering a membrane specific anti-carcinoembryonic antigen (CEA) (this paper uses the original term CEA for formally designated CEACAM5) antibody (PR1A3) on its ability to enhance killing colorectal cancer (CRC) cell lines by human immune effector cells was assessed. In vivo efficacy also tested. modified using EBNA cotransfected with β-1,4-N-acetylglucosaminyltransferase III and humanised hPR1A3 genes. resulting alteration Fc segment glycosylation pattern enhances...
Abstract Aim Extralevator abdominoperineal excision (ELAPE) has been advocated to optimize clearance of lower third rectal cancers with an involved or threatened circumferential resection margin. ELAPE could reduce positive margins and specimen perforation compared standard excision. However, there can be difficulties ELAPE, particularly in identifying the anterior plane male patients. Usually, dissection is performed prone position, which hazardous, obese patients whom wound problems are...
ABSTRACT Background: An advanced bipolar (ABP) tissue sealer designed for division of major vessels in open procedures was evaluated a prospective post-market study. The objective to provide clinical data assessment vessel transection, hemostatic performance and ease use the ABP device during colectomy, gynecologic, thoracic operations. Materials methods: test used colectomy (n = 36), gynecologic 44), 21) procedure groups. Vessels transected with were graded intraoperatively on hemostasis...
There is considerable debate as to whether vascular surgery should be a subspecialty separate from general surgery. This study examines the changing relationship between and in district surgical unit over 16 years.A detailed survey of referrals, admissions operations one was carried out 3 months 2003. compared with similar surveys 1989, 1990 1995. In addition 3-month audit performed 2005 following decision by Primary Care Trust (PCT) reduce varicose vein referrals.There significant increase...