A5070658947- interferon and immune responses
- 14-3-3 protein interactions
- NF-κB Signaling Pathways
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- Parkinson's Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
Boston University
2018-2022
Delaware State University
2015-2017
University of Wisconsin–Madison
2014
Synthetic gene circuits that precisely control human cell function could expand the capabilities of gene- and cell-based therapies. However, platforms for developing in primary cells drive robust functional changes vivo have compositions suitable clinical use are lacking. Here, we developed synthetic zinc finger transcription regulators (synZiFTRs), which compact based largely on human-derived proteins. As a proof principle, engineered switches allow precise, user-defined over...
Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. highly regulated at the transcriptional level by combinations of transcription factors (TFs) recruit cofactors machinery. Here, we mined through three decades studies to generate comprehensive database, CytReg, reporting 843 647 interactions between TFs cytokine genes, human mouse respectively. By integrating CytReg with other functional datasets, determined general...
Proper cytokine gene expression is essential in development, homeostasis and immune responses. Studies on the transcriptional control of genes have mostly focused highly researched transcription factors (TFs) cytokines, resulting an incomplete portrait regulation. Here, we used enhanced yeast one-hybrid (eY1H) assays to derive a comprehensive network comprising 1380 interactions between 265 TFs 108 promoters. Our eY1H-derived greatly expands known repertoire TF-cytokine set regulate genes....
Progranulin (GRN) is a ubiquitously expressed, cysteine-rich, secreted glycoprotein. Mutations in the GRN gene have been identified as cause of frontotemporal dementia (FTD) seen pathologically form lobar degeneration (FTLD). It suggested that non-loss-of-function mutations FTD. Another protein, TAR DNA-binding protein about 43 kDa (TDP-43) constitutes significant portion ubiquitinated aggregate tau-negative FTLD (FTLD-U). TDP-43 found to be abnormally phosphorylated, mislocalized cytoplasm...
Abstract Cytokines play a central role in immune development, pathogen responses, and diseases. are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit cofactors machinery. Here, we review three decades studies to generate comprehensive database reporting 843 647 interactions between TFs cytokines genes, human mouse respectively ( http://cytreg.bu.edu ). We provide historic perspective on cytokine regulation discussing research trends...
Phosphorylated TDP-43 pathology has been described in up to 50% of sporadic and 14% familial Alzheimer’s disease cases. A recent study from Josephs et al., 2015, looked at 342 pathologically determined cases 57% were positive for TDP-43. This also showed that subjects 10X more likely have cognitive impairment age death compared with those without pathology. We describe a mouse model selective expression the hippocampus cortex an APP/PS1 background. is essential development because knockout...
Alzheimer's disease (AD) is a neurodegenerative characterized by extensive neuronal loss and the accumulation of amyloid plaques neurofibrillary tangles composed hyperphosphorylated tau proteins. Similar to tau, pathological TDP-43 becomes hyper-phosphorylated present in inclusions observed up 50% sporadic cases. However, much remains unknown about mechanisms proteinopathy contribution AD. Tau phosphorylation regulated calcium phosohatase calcineurin (PPP3CA or PP2B). Calcineurin...
Recent studies have shown that phosphorylated TDP-43 pathology is present in up to 50% of sporadic Alzheimer's disease (AD) cases. Although mislocalized and has been observed several neurodegenerative diseases, little known about the role plays AD pathology. We describe a mouse model selective human TDP-43ΔNLS (defective nuclear localization signal) expression hippocampus cortex an APP/PSEN1 mouse. utilize cell-specific inducible system express signal defective hippocampal cortical neuronal...