A5026262751- interferon and immune responses
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Respiratory viral infections research
- Cervical Cancer and HPV Research
- Reproductive tract infections research
- Helicobacter pylori-related gastroenterology studies
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Maternal and Perinatal Health Interventions
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- MicroRNA in disease regulation
- Infectious Diseases and Tuberculosis
- Reproductive Health and Contraception
- Amoebic Infections and Treatments
- Otolaryngology and Infectious Diseases
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Maternal and fetal healthcare
- RNA Research and Splicing
Denver Health Medical Center
2024
Washington Poison Center
2024
Saint Joseph Hospital
2024
Intermountain Healthcare
2024
University of Colorado Denver
2024
University of Colorado Health
2024
University of Colorado System
2022
University of Southern California
2020
United States Food and Drug Administration
2015-2019
Center for Biologics Evaluation and Research
2015-2019
Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state (AVS). However, the mechanisms that govern AVS is poorly defined. Using a respiratory epithelial cell line deficient in IRF1, we demonstrate higher susceptibility infection with vesicular stomatitis virus (VSV) influenza. IRF1-mediated restriction VSV IFN-independent, as IRF1 regulates constitutive expression ~250 genes,...
A global pandemic caused by a novel coronavirus (Covid-19) has created unique challenges to providing timely care for cancer patients. In early-stage cervical cancer, postponing hysterectomy 6-8 weeks is suggested as possible option in the Covid-19 burdened hospitals. Yet, literature examining impact of surgery wait-time on survival remains scarce. This study examined association between 8 and oncologic outcome women with cancer.This single institution retrospective observational at tertiary...
After viral infection, type I and III interferons (IFNs) are coexpressed by respiratory epithelial cells (RECs) activate the ISGF3 transcription factor (TF) complex to induce expression of a cell-specific set interferon-stimulated genes (ISGs). Type IFNs share canonical signaling pathway, suggesting that they redundant. Animal in vitro models, however, have shown not Because TFs dictate cellular phenotype function, we hypothesized focusing on TF-ISG will reveal critical combinatorial...
Micro(mi)RNAs are 21- to 23-nt RNAs that regulate multiple biological processes. In association with Argonaute (Ago) proteins and other factors form the RNA-induced silencing complex (RISC), miRNAs typically bind mRNA 3′ untranslated regions (UTRs) repress protein production through antagonizing translation transcript stability. For a given mRNA–miRNA interaction, cis -acting RNA elements trans RNA-binding (RBPs) may influence fate. This is particularly true of hepatitis C virus (HCV) genome...
Introduction There is no clear guidance for the optimal setting dilation and curettage (D&C) management of first-trimester pregnancy failure. Identifying patients at risk clinically significant blood loss time D&C may inform a provider's decision regarding procedure. We aimed to identify factors predictive 200mL or greater D&C. Methods This retrospective cohort study diagnosed with failure gestational age less than 11 weeks who underwent surgical single safety net academic institution...
Abstract Types I and III interferon (IFN) are co-expressed by respiratory epithelial cells (REC) in response to viral infection. In turn, these IFN stimulate neighboring REC express a set of interferon-stimulated genes (ISG) through shared signaling pathways. Whether types have non-redundant functions anti-viral defense infections is unknown. Because transcription factors dictate cellular phenotype function, we hypothesized that ISG (TF-ISG) mediate or IFN. We treated BEAS-2B human with...
INTRODUCTION: The incidence of STIs, specifically gonorrhea, chlamydia, and trichomoniasis among Los Angeles County residents is on the rise. One possible explanation inadequate treatment, especially sexual partners. Expedited partner therapy (EPT) a method treating patients' partners without separate healthcare visit, which has been shown to decrease persistent and/or recurrent infections. We report quality improvement outcomes following interventions help increase rates EPT provision....
Abstract Purpose: To identify patient factors associated with medical management failure and hospital readmission among patients admitted a diagnosis of tuboovarian abscess at public in Los Angeles, California. Methods: We conducted retrospective chart review admissions for from January 2014 through August 2019, describing treatment plans their subsequent outcomes. Patient management, as defined by requiring image-guided drainage or surgery, were identified via bivariate analyses, using...